The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia: a retrospective comparative register study

M.D., F.I.A.C. Måns Åkerman; Mokarami, Parisa; Källén, Karin; Olofsson, Per

doi:10.1080/14767058.2017.1315098

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…This regulation may prevent the death of the SGA fetuses. Numerous studies have noted that SGA fetuses demonstrate a similar level of glucose in the cord blood as AGA fetuses, despite the concentration of insulin being significantly depleted (Åkerman et al 2018; Bozzetti et al 1988; Unterman et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

et al. 2019

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A linkage of dichorionic (DC) twin pregnancies with selective intrauterine growth restriction (IUGR) to alterations in placental gene expression is unclear. The aim of the study was to identify placental genes related to hypoxia, adipogenesis and human growth which may contribute to IUGR development. The study group (IUGR/AGA) comprised dichorionic (DC) twin pregnancies, where the weight of the twins differed by > 15%; in addition, one twin was small for gestational age (< 10th percentile-SGA) (IUGR) while the other was appropriate for gestational age (> 10th percentile-AGA). In the control group (AGA/AGA), both fetuses were AGA and their weights differed by < 15%. In the first step (selection), placental expression of 260 genes was analysed by commercial PCR profiler array or qPCR primer assay between six pairs of IUGR/AGA twins. In the second stage (verification), the expression of 20 genes with fold change (FC) > 1.5 selected from the first stage was investigated for 75 DC pregnancies: 23 IUGR/AGA vs. 52 AGA/AGA. The expression of Angiopoetin 2, Leptin and Kruppel-like factor 4 was significantly higher, and Glis Family Zinc Finger 3 was lower, in placentas of SGA fetuses (FC = 3.3; 4.4; 1.6; and − 1.8, respectively; p < 0.05). The dysregulation of gene expression related to angiogenesis and growth factors in placentas of twins born from IUGR/AGA pregnancies suggest that these alternations might represent biological fetal adaptation to the uteral condition. Moreover, DC twin pregnancies may be a good model to identify the differences in placental gene expression between SGA and AGA fetuses.

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Section: Discussionmentioning

confidence: 99%

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

et al. 2019

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“…Exposure of pregnant rats to hypoxia resulted in FGR, fetal hypoxia, and acidosis 178 . Several studies confirmed elevated LDH and lactate levels in pregnant women and fetuses with growth restriction 179–182 . Karaer et al.…”

Section: Glycolysis In Pathological Pregnancymentioning

confidence: 98%

“…178 Several studies confirmed elevated LDH and lactate levels in pregnant women and fetuses with growth restriction. [179][180][181][182] Karaer et al analyzed placental metabolite profiles by 1 H HR-MAS NMR and detected increased lactate concentrations in FGR placentas. 183 Nevertheless, another study based on 1 H NMR spectroscopy did not mention alterations in lactate levels of FGR placentas.…”

Section: Fetal Growth Restrictionmentioning

confidence: 99%

Glycolysis: A fork in the path of normal and pathological pregnancy

Gou,

Zhang

2023

The FASEB Journal

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Glucose metabolism is vital to the survival of living organisms. Since the discovery of the Warburg effect in the 1920s, glycolysis has become a major research area in the field of metabolism. Glycolysis has been extensively studied in the field of cancer and is considered as a promising therapeutic target. However, research on the role of glycolysis in pregnancy is limited. Recent evidence suggests that blastocysts, trophoblasts, decidua, and tumors all acquire metabolic energy at specific stages in a highly similar manner. Glycolysis, carefully controlled throughout pregnancy, maintains a dynamic and coordinated state, so as to maintain the homeostasis of the maternal–fetal interface and ensure normal gestation. In the present review, we investigate metabolic remodeling and the selective propensity of the embryo and placenta for glycolysis. We then address dysregulated glycolysis that occurs in the cellular interactive network at the maternal–fetal interface in miscarriage, preeclampsia, fetal growth restriction, and gestational diabetes mellitus. We provide new insights into the field of maternal–fetal medicine from a metabolic perspective, thus revealing the mystery of human pregnancy.

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“…Blood lactate concentration in critically ill and injured patients can be used to detect tissue hypoxia at an early stage which is simple, cheap and quick marker to predict and asses illness severity and outcome (7).…”

Section: Introductionmentioning

confidence: 99%

Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

Ali¹,

Khalifa²,

El-Bana³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Perinatal asphyxia has been defined as the lack of oxygen that occurs either before, during, or after birth. Many studies in recent past have suggested that an increased number of nucleated red blood cells (NRBC) in umbilical cord blood may be a useful marker to identify birth asphyxia. Objective: To find out the relationship between meconium-stained amniotic fluid and NRBC in umbilical cord blood. Patients and Methods: This was a comparative cross-section study, which was carried out at Obstetrics and Gynecology Department, Zagazig University Hospitals on 54 cases divided into 2 groups: (Group 1): included 27 pregnant females with meconium-stained amniotic fluid who gave birth to neonates (male 15 and female12) showing criteria of perinatal asphyxia, (Group 2): included 27 pregnant females with clear amniotic fluid who gave birth to neonate's apparently healthy full-term (male17 and female10) as control group with no obstetrical problems. Results: There was no statistically significant difference between case and control groups in basic characteristics or obstetric history. NRBC's/100 WBCs and lactate were highly significantly increased in group 1. The mean value of lactate was increasing in relation to stage of hypoxic ischemic encephalopathy (HIE). Conclusion:There was a strong correlation between markers of acute asphyxia (i.e., umbilical artery blood nucleated red blood cells and lactate,) and meconium-stained liquor cases. These markers were significantly elevated in newborns with meconium-stained amniotic fluid.

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The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia: a retrospective comparative register study

Cited by 4 publications

References 19 publications

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

Glycolysis: A fork in the path of normal and pathological pregnancy

Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

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