The sleeping brain in Parkinson's disease: A focus on REM sleep behaviour disorder and related parasomnias for practicing neurologists

Bhidayasiri, Roongroj; Sringean, Jirada; Rattanachaisit, Watchara; Truong, Daniel D.

doi:10.1016/j.jns.2017.01.018

Cited by 12 publications

(8 citation statements)

References 66 publications

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“…The most common PD‐associated disturbances in sleep–wake transitioning include increased sleep latency, frequent awakenings, and sleep fragmentation, resulting in wakefulness after sleep onset (WASO) and reduced total sleep time 6,16‐25 . The parasomnias associated with PD have also gained much attention and include rapid eye movement sleep behavior disorder (RBD), periodic limb movements in sleep (PLMS), and restless legs syndrome 12‐14 . Sleep disorders such as RBD can even be the first prodromal symptom of PD prior to the emergence of formal motor symptoms 10,26,27 .…”

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confidence: 99%

“…A wide spectrum of sleep disorders have been implicated in PD, encompassing disorders of sleep–wake transition as well as parasomnias involving abnormal movements during various phases of sleep 11‐15 . The most common PD‐associated disturbances in sleep–wake transitioning include increased sleep latency, frequent awakenings, and sleep fragmentation, resulting in wakefulness after sleep onset (WASO) and reduced total sleep time 6,16‐25 .…”

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confidence: 99%

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The Neurophysiology of Sleep in Parkinson's Disease

et al. 2021

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Sleep disturbances are among the most common nonmotor complications of Parkinson's disease (PD), can present in prodromal stages, and progress with advancing disease. In addition to being a symptom of neurodegeneration, sleep disturbances may also contribute to disease progression. Currently, limited options exist to modulate sleep disturbances in PD. Studying the neurophysiological changes that affect sleep in PD at the cortical and subcortical level may yield new insights into mechanisms for reversal of sleep disruption. In this article, we review cortical and subcortical recording studies of sleep in PD with a particular focus on dissecting reported electrophysiological changes. These studies show that slow-wave sleep and rapid eye movement sleep are both notably disrupted in PD. We further explore the impact of these electrophysiological changes and discuss the potential for targeting sleep via stimulation therapy to modify PD-related motor and nonmotor symptoms.

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confidence: 99%

The Neurophysiology of Sleep in Parkinson's Disease

et al. 2021

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“…Parasomnias are the fifth type characterized by abnormal behavior, anxiety, agitation, emotional breakdown, dream with hallucination, falling asleep, sleep disturbances, rapid eye movement (REM) with undesirable body movements, walking or talking during sleep. Lastly, Sleep-Related Movement Disorders with symptoms include drowsiness, clumsiness, confusion, irritability, instability with imbalance; tremor, ataxia are related to cognitive dysfunction, dementia, and PD [132] .…”

Section: Risk Factors Influencing Dementia In Admentioning

confidence: 99%

Molecular mechanisms in Alzheimer's disease and the impact of physical exercise with advancements in therapeutic approaches

Siddappaji

Gopal

2021

AIMS Neuroscience

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Alzheimer's disease (AD) is one of the most common, severe neurodegenerative brain disorder characterized by the accumulation of amyloid-beta plaques, neurofibrillary tangles in the brain causing neural disintegration, synaptic dysfunction, and neuronal death leading to dementia. Although many US-FDA-approved drugs like Donepezil, Rivastigmine, Galantamine are available in the market, their consumption reduces only the symptoms of the disease but fails in potency to cure the disease. This disease affects many individuals with aging. Combating the disease tends to be very expensive. This review focuses on biochemical mechanisms in the neuron both at normal and AD state with relevance to the tau hypothesis, amyloid hypothesis, the risk factors influencing dementia, oxidative stress, and neuroinflammation altogether integrated with neurodegeneration. A brief survey is carried out on available biomarkers in the diagnosis of the disease, drugs used for the treatment, and the challenges in approaching therapeutic targets in inhibiting the disease pathologies. This review conjointly assesses the demerits with the inefficiency of drugs to reach targets, their side effects, and toxicity. Optimistically, this review directs on the advantageous strategies in using nanotechnology-based drug delivery systems to cross the blood-brain barrier for improving the efficacy of drugs combined with a novel neuronal stem cell therapy approach. Determinately, this review aims at the natural, non-therapeutic healing impact of physical exercise on different model organisms and the effect of safe neuromodulation treatments using repetitive Transcranial Magnetic Stimulation (rTMS), transcranial Electrical Stimulation (tES) in humans to control the disease pathologies prominent in enhancing the synaptic function.

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“…RBD is characterized by vocalizations and/or complex motor behaviors occuring during REM sleep, associated with REM sleep without atonia (RSWA), which may result in injury to patient and/or to bed partner . RSWA and RBD share some pathophysological mechanisms, and they may reflect neuronal loss and α‐synuclein degeneration of Lewy type in brainstem nuclei modulating REM sleep atonia, consisting locus coeruleus‐subcoeruleus complex, the raphe nucleus, and substantia nigra …”

Section: Introductionmentioning

confidence: 99%

“…Aside being an important clinical issue in sleep medicine, RBD may also occur secondary to other sleep disorders like narcolepsy or other conditions like autoimmune/inflammatory disorders, brain lesions, or medication‐induced cases . Presence of RBD is accepted as a significant risk factor for the emergence of neurodegenerative disorders including Parkinson's disease (PD), dementia with Lewy body, and multiple system atrophy . On the other hand, clinical significance of iRSWA is not known, unless RBD accompanies it.…”

Section: Introductionmentioning

confidence: 99%

Rapid eye movement sleep without atonia constitutes increased risk for neurodegenerative disorders

2019

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Objectives REM (rapid eye movement) sleep without atonia (RSWA) is a polysomnographic finding used in diagnosis of REM sleep behavior disorder (RBD). Clinical significance of idiopathic RSWA (iRSWA) unaccompanied by RBD is not known. We designed a prospective study to investigate whether iRSWA constitutes an increased risk for developing neurodegenerative disorders. Materials and methods Between January 2010 and December 2014, a total of 4362 patients underwent a full‐night video‐polysomnography. Upon detailed clinical and polysomnographical examination, patients with iRSWA and idiopathic RBD (iRBD) were enrolled into this study and followed up at every six months for at least 4 years up to 9 years. Results We had a total of 31 patients with iRBD and 67 patients with iRSWA. Mean age was higher in iRBD group than those in iRSWA group (P = .016). Restless legs syndrome/Willis‐Ekbom disease was significantly more common in patients with iRBD than those in patient with iRSWA (P < .001). Eighteen patients with iRSWA (26.8%) developed iRBD after 2.6 + 2.2 years. Six patients with iRSWA (8.9%) developed neurodegenerative disorders following 2.4 + 1.5 years; four were diagnosed as Parkinson's disease (PD) and two developed probable Alzheimer‐type dementia. In patients with iRBD, eight patients (25.8%) developed neurodegenerative disorders—all was Parkinson's disease—following 2.6 + 2.2 years. Development of neurodegenerative diseases was positively correlated with age (P < .001) and periodic leg movements in sleep in both groups (P < .010). Conclusions These results show that iRSWA may also be accepted as a risk factor in the development of PD or neurodegenerative diseases. Advanced age and periodic leg movements in sleep seem to be correlated with higher risk.

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The sleeping brain in Parkinson's disease: A focus on REM sleep behaviour disorder and related parasomnias for practicing neurologists

Cited by 12 publications

References 66 publications

The Neurophysiology of Sleep in Parkinson's Disease

The Neurophysiology of Sleep in Parkinson's Disease

Molecular mechanisms in Alzheimer's disease and the impact of physical exercise with advancements in therapeutic approaches

Rapid eye movement sleep without atonia constitutes increased risk for neurodegenerative disorders

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