The Sl-a Histocompatibility System in the Sus Scrofa Species

Research on the therapeutics of intense abdominal irradiations in pigs

“…Intestinal grafts, whether early or delayed, had a rather negative effect on the survival period; median survivals following these two types of graft were of the same order (9 and 13 days). it should be noted that the median survival of control receiving an intestinal graft was 49.5 days, and that some subjects survived for more than 2 years [40].…”

“…The Large-White pigs were used for all the surgical operations (enterectomy, grafts) because they were still lean at 4 to 5 months and the size of the farrow (8 to 12 subjects against 3 to 5 for the miniatures) made it easy to find compatible litter mates for the major SLA histoeompatibility complex [40].…”

“…As in the preceding case, the grafts were carried out between identical SLA litter mates [40], according to Kunlin's technique [22]; the graft generally involved J/3 of the jejunum and 4/5 of the ileum. For seven pairs, cross-grafting was carried out 3 to 4 h after irradiation, the healthy graft being placed in the irradiated subject and the irradiated graft into the healthy subject [10].…”

“…40 Conversely, in comparison with a "sensu stricto" intestinal irradiation, exposure of the posterior half of the body will have an aggravating effect because it will also involve the liver, pancreas and kidneys. We shall accordingly describe the development of symptoms in pigs irradiated in part, their survival, the possible restoration of nutritional functions in relation to the irradiation dose (between 950 and 1750 rad), various surgical operations carried out, and the different reanimation methods used.…”

The Pig as a Model to Assess the Effect of Class II MHC Antigen Matching on Renal Allograft Survival

“…Large animals such as dogs [1], monkeys [2], and swine [3] have been valuable models for transplantation biology both because of their size, which permits surgical manipulations similar to those in man, and because they provide an intermediate step between rodents and man in which to reexamine new experimental results. Although most biological principles are conserved among species, fine tuning of the immune system is in some cases different enough to make results in anyone species not directly applicable to man.…”