The Skok legacy and beyond: Molecular mechanisms of slow synaptic excitation in sympathetic ganglia

Brown, David A.

doi:10.1007/s11062-007-0033-6

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…[Adapted from Fig. 4 in Brown, 2007. ] B. M2R-induced outward K + current in an isolated rabbit cardiac sino-atrial node cell.…”

Section: For Technical Details)]mentioning

confidence: 99%

Regulation of neural ion channels by muscarinic receptors

Brown

2018

Neuropharmacology

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The excitable behaviour of neurons is determined by the activity of their endogenous membrane ion channels. Since muscarinic receptors are not themselves ion channels, the acute effects of muscarinic receptor stimulation on neuronal function are governed by the effects of the receptors on these endogenous neuronal ion channels. This review considers some principles and factors determining the interaction between subtypes and classes of muscarinic receptors with neuronal ion channels, and summarizes the effects of muscarinic receptor stimulation on a number of different channels, the mechanisms of receptor - channel transduction and their direct consequences for neuronal activity. Ion channels considered include potassium channels (voltage-gated, inward rectifier and calcium activated), voltage-gated calcium channels, cation channels and chloride channels. This article is part of the Special Issue entitled 'Neuropharmacology on Muscarinic Receptors'.

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“…[Adapted from Fig. 4 in Brown, 2007. ] B. M2R-induced outward K + current in an isolated rabbit cardiac sino-atrial node cell.…”

Section: For Technical Details)]mentioning

confidence: 99%

Regulation of neural ion channels by muscarinic receptors

Brown

2018

Neuropharmacology

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“…M1 mAChRs couple to Gq and consequently activate phospholipase C(β) (PLCβ); membrane PIP2 is thereby hydrolysed and reduced to a level that cannot sustain channel opening. This depletion can be both profound (>90%) and rapid [20,21], with a time course approaching that for Mcurrent inhibition in SCG neurons [5].…”

Section: M1 Receptorsmentioning

confidence: 99%

“…(Note that the recorder was speeded up ×100 for 2.5 sec during the discharge). Data of A, B, C, and D are from [5], [6], [7], and [5], respectively. Р и с.…”

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confidence: 99%

The Other (Muscarinic) Acetylcholine Receptors in Sympathetic Ganglia: Actions and Mechanisms

Brown

2013

Neurophysiology

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Acetylcholine released from preganglionic sympathetic fibers can activate two types of acetylcholine receptors in sympathetic neurons, nicotinic and muscarinic. The former are ligandgated ion channels responsible for direct synaptic transmission; the latter are G proteincoupled receptors that mediate various indirect modulatory effects. Most mammalian sympathetic neurons express three muscarinic receptor subtypes, M1, M2, and M4; some also express M3 receptors. Activation of M1 receptors stimulates the G protein Gq and causes a slow postsynaptic depolarization and an increase in the excitability, ultimately leading to an asynchronous action potential discharge, which can "break through" the nicotinic ganglion block. This is largely mediated by closure of voltagegated K + channels (the M channels) composed of Kv7.2 and Kv7.3 subunits and results from hydrolysis and depletion of membrane phosphatidylinositol4,5bisphosphate. Activation of M2 receptors hyperpolarizes and inhibits the postsynaptic neuron by opening G proteingated inwardlyrectifying Kir K + channels via the G protein Gi. M4 receptors inhibit Ntype (CaV(2)) calcium channels via the G protein Go. In the postganglionic neuron somata, this enhances the excitability by reducing calciumdependent potassium currents. Conversely, in postganglionic processes and axon terminals, CaV(2)mediated inhibition reduces norepinephrine release and inhibits postganglionic transmission. Different muscarinic receptors may be anatomically segregated with their cognate G proteins and (in some cases) ion channels in signalling microdomains.

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The Skok legacy and beyond: Molecular mechanisms of slow synaptic excitation in sympathetic ganglia

Cited by 2 publications

References 30 publications

Regulation of neural ion channels by muscarinic receptors

Regulation of neural ion channels by muscarinic receptors

The Other (Muscarinic) Acetylcholine Receptors in Sympathetic Ganglia: Actions and Mechanisms

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