The Skin Immune System (SIS): Distribution and Immunophenotype of Lymphocyte Subpopulations in Normal Human Skin

CD3+ and Pax5+ Lymphocytes were not Found in the Dermis of Normal Skin from the Dorsolateral Thorax of Dogs

“…Perhaps the number of resident dermal T-lymphocytes varies with body site. Our failure to identify Pax5+ dermal B-lymphocytes is consistent with previous studies in humans 3) and rodents 18) .…”

“…Resident dermal B-lymphocytes were not found in human or murine skin 3,18) . To the authors' knowledge, no other studies have investigated the prevalence of B-lymphocytes in the dermis of normal skin.…”

“…Resident epidermal T-lymphocytes play an important role in the skin-associated lymphoid tissue (SALT) or skin immune system (SIS) in humans and mice 3,17,18) .…”

“…Resident dermal T-lymphocytes have been demonstrated in the normal skin of humans 3,8) , cattle 10) , sheep 9) , and in 13 dogs 12,15) . Resident epidermal Blymphocytes have not been demonstrated in humans 3,16) , rodents 18) , dogs 5) , cats 19) , horses 20) , or alpacas 6) . Further, resident dermal B-lymphocytes have not been found in humans 3) or rodents 18) .…”

“…Resident epidermal Blymphocytes have not been demonstrated in humans 3,16) , rodents 18) , dogs 5) , cats 19) , horses 20) , or alpacas 6) . Further, resident dermal B-lymphocytes have not been found in humans 3) or rodents 18) . Pax5 has been evaluated as a pre-plasma cell, B-lymphocyte marker for canine lymphocytes 1,21) .…”