The skin-gut relationship in dermatitis herpetiformis

Marks, Janet; Shuster, Sam; Young, So-Yu; Felix, R; Watson, Alexander

doi:10.1111/j.1365-2133.1974.tb12500.x

Cited by 3 publications

(4 citation statements)

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“…The IELs associated with 500 enterocytes were counted and the results expressed as IELs per 1000 enterocytes. We have previously reported that in by no means all patients with DH has the IEL count been abnormal (Marks, 1974;), Fig. 9 shows the results to date in Newcastle-upon-Tyne patients.…”

Section: What Is Coeliac Disease ? Where Do We Draw the Line Between mentioning

confidence: 89%

Dogma and dermatitis herpetiformis*

Marks

1977

Clin Exp Dermatol

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Section: What Is Coeliac Disease ? Where Do We Draw the Line Between mentioning

confidence: 89%

Dogma and dermatitis herpetiformis*

Marks

1977

Clin Exp Dermatol

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“…Since our study was begun, the value of examining skin biopsies for IgA deposits has become increasingly apparent. Nevertheless, the precise diagnostic significance of such deposits is still not clear (Fry & Seah, 1974;Marks et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Clinical response of dermatitis herpetiformis skin lesions to a gluten-free diet

et al. 1976

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Patients with dermatitis herpetiformis have been studied prospectively for 2 years to assess the effect of a gluten-free diet (GFD) on control of the skin lesions. Daily requirements for oral medication with sulphapyridine or dapsone were reduced by GFD treatment and if complete clinical remission of the skin disease occurred, it was maintained while the diet was strictly observed. However, complete remission did not occur significantly more often in GFD-treated patients than in patients taking a normal diet. Many of the latter group exhibited variation in their drug dose requirements during the period of study. GFD treatment seems desirable for the majority of patients with dermatitis herpetiformis, not only to correct the intestinal abnormality but also to minimize the dose of drugs necessary to control the skin lesions.

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“…The specificity of these findings has been doubted by Marks (1974), Alexander (1975) and Scott et al (1976) while Ross et al (1977) found IgA deposits in the dermo-epidermal junction and/or dermal papillae in eight of 16 coeliac patients and in seven of 54 control subjects. The incidence of IgA deposits in this series (50%) is considerably less than that reported by others which varies from 83 to 100% (Fry and Seah, 1974;Seah and Fry, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…The skin rash also is claimed by Fry et al (1973) and by Heading et al (1976) to show improvement but this is doubted by Marks and Shuster (1970), Weinstein et al (1971), and by Marks (1974). A point considered in detail only by Fry et al (1969) is the state of the jejunal mucosa in relation to the response of the skin lesion while on a gluten free diet.…”

mentioning

confidence: 98%