The Skin and Bladder of Amphibians as Models for the Mammalian Nephron

Dicker, S. E.

doi:10.1159/000178195

Cited by 24 publications

(5 citation statements)

References 8 publications

(9 reference statements)

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“…19 It has been shown that Ang-(1-7) increases osmotic water permeability in isolated toad skin, 20 a tissue with functional properties similar to those of the distal mammalian nephron. 21 This finding is in keeping with the antidiuretic action of Ang-(1-7) in rats 9,10,18 and in mice. 13 Moreover, it was demonstrated recently that Ang-(1-7) but not Ang IV produces a significant dose-dependent increase in water permeability in the IMCDs accompanied by an increase in cAMP levels.…”

Section: Discussionsupporting

confidence: 74%

Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney

et al. 2004

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Section: Discussionsupporting

confidence: 74%

Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney

et al. 2004

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“…Tissue such as frog skin and the mammalian intestine have structural and functional properties similar to those of the mammalian nephron (Dicker, 1970) and respond to angiotensin with uptake of sodium and water at low doses and inhibition of transport at high doses (Coviello, 1972;Bolton et al, 1975). Recently we (Levens et al, 1979b(Levens et al, , 1980 have shown that the stimulation of intestinal sodium transport measured as water transport produced by angiotensin can be inhibited by treatment of the animals with phentolamine or reserpine.…”

Section: Studies Of Non-renal Transporting Epitheliamentioning

confidence: 99%

Role of the intrarenal renin-angiotensin system in the control of renal function.

Levens¹,

Peach²,

Carey³

1981

Circulation Research

178

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IN THIS review article, we will assess the evidence for the presence and the mechanism of the intrarenal renin-angiotensin system acting as a local hormonal system in the control of renal function. First, we will review the evidence for the presence of a renin-angiotensin system in the kidney. Second, using results of our own and other studies, we will develop the concept that the intrarenal renin-angiotensin system acts as a local hormonal system in the control of renal function. Third, we will discuss experimental observations on the intrarenal effects of angiotensin II. Fourth, we will evaluate the evidence for a direct renal tubular action of angiotensin II. Fifth, we will assess the role of the intrarenal renin-angiotensin system in renal autoregulation. Finally, we will speculate on the function of the intrarenal renin-angiotensin system in the regulation of fluid and electrolyte homeostasis in general.

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“…Of these factors, only (c) now remains to be confirmed in R. cancrivora, and the sequence of events outlined does seem to be a reasonable one. If the controlled permeability of the amphibian bladder can be used, as it so frequently has been (Dicker, 1970) as a model ofthe controlled permeability of distal parts of the mammalian nephron, then the pattern of physiological response outlined above for R. cancrivora may have relevance also to understanding of the regulation of water and urea in the plasma of higher vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Permeability of urinary bladder of Rana cancrivora to urea in the presence of oxytocin

Chew¹,

Elliott²,

Wong³

1972

The Journal of Physiology

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SUMMARY1. When Rana cancrivora collected from fresh water had been exposed for 3 days to saline solutions having osmolalities from 280 to 690 m-osmole/ kg, urea concentrations in plasma and urine appeared to come into equilibrium, and were from 70 to 200 m-mole/l.2. Plasma urea level of fresh water R. cancrivora (48 m-mole/l.) was doubled (82 m-mole/l.) after 8 hr of exposure to 270 m-osmolal saline. It continued the same after 24 hr of exposure.3. When isolated urinary bladders of R. cancrivora were exposed to Ringer on the serosal aspect and one-fifth Ringer on the mucosal aspect, then in response to this osmotic difference of 190 m-osmole/kg, the rate of fluid movement (mucosa to serosa), which was 10-3(±2)#l./cm2.hr, was not significantly altered when up to 60 % of the NaCl of the Ringer solution was substituted by urea.4. Under the same circumstances, when oxytocin (50 m-u./ml.) was present in the serosal solution, the rate of fluid movement (mucosa to serosa) was 133.2( ± 7.9) tl./cm2.hr in the absence of urea; it was progressively decreased by the presence of urea until, when 80 % of the NaCl had been substituted by urea, the rate of fluid movement was reduced to 14.5( ± 4.0) ,ul./cm2.hr.5. The diminished rate of fluid movement under the above circumstances could not be correlated with serosal urea concentration, with serosal availability of Na+, nor with Na+ concentration difference across the bladder wall. It appeared to be directly related to the 'non-urea osmotic difference' across the bladder wall provided by solutes other than urea.6. When isolated bladders were exposed to an osmotic difference of 190 m-osmole/kg, but having 25 mm urea present in the mucosal solution, then fluid moved from mucosa to serosa at a rate of 10.4( ± 1-3) ttl./cm2 . hr in the absence of oxytocin and 124( ± 9) Il./cm2 . hr when oxytocin (50 m-u./ 758 M.-M. CHEW, A. B. ELLIOTT AND H. Y. WONG ml.) was present. In the former case no urea passed across the bladder wall, but in the latter case urea passed from mucosa to serosa at a rate of 3-16( ± 0.3) /tmole/cm2.hr. The fluid moving from mucosa to serosa thus contained urea 25-5 m-mole/l.7. Vasotocin (10-9 M), which is equipotent with oxytocin (50 m-u./ml.) in affecting permeability of the isolated urinary bladder to water, was also equipotent in producing a reduced rate of water fluid movement in the presence of 40 % urea (vasotocin, 63 /u1./cm2.br; oxytocin, 59 p1./cm2.br). 9. The hypothesis is presented that hormone-induced permeability of the urinary bladder to urea contributes to the immediate adjustment of plasma urea level by which R. cancrivora survives when exposed to high environmental salinity.

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The Skin and Bladder of Amphibians as Models for the Mammalian Nephron

Cited by 24 publications

References 8 publications

Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney

Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney

Role of the intrarenal renin-angiotensin system in the control of renal function.

Permeability of urinary bladder of Rana cancrivora to urea in the presence of oxytocin

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