The skeletal muscle secretome: an emerging player in muscle–bone crosstalk

Hamrick, Mark W.

doi:10.1038/bonekey.2012.60

Cited by 114 publications

(110 citation statements)

References 69 publications

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“…Extraction of SCFA was performed as in ref. 44. Briefly, volatile compounds, including the internal standard (valeric acid), were acidified, extracted with diethyl ether, and back-extracted into sodium phosphate buffer.…”

Section: Methodsmentioning

confidence: 99%

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Gut microbiota induce IGF-1 and promote bone formation and growth

Yan

Herzog

Tsang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

541

531

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Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth and homeostasis have only recently begun to be explored. Here, we report that colonization of sexually mature germ-free (GF) mice with conventional specific pathogen-free (SPF) gut microbiota increases both bone formation and resorption, with the net effect of colonization varying with the duration of colonization. Although colonization of adult mice acutely reduces bone mass, in long-term colonized mice, an increase in bone formation and growth plate activity predominates, resulting in equalization of bone mass and increased longitudinal and radial bone growth. Serum levels of insulin-like growth factor 1 (IGF-1), a hormone with known actions on skeletal growth, are substantially increased in response to microbial colonization, with significant increases in liver and adipose tissue IGF-1 production. Antibiotic treatment of conventional mice, in contrast, decreases serum IGF-1 and inhibits bone formation. Supplementation of antibiotic-treated mice with short-chain fatty acids (SCFAs), products of microbial metabolism, restores IGF-1 and bone mass to levels seen in nonantibiotic-treated mice. Thus, SCFA production may be one mechanism by which microbiota increase serum IGF-1. Our study demonstrates that gut microbiota provide a net anabolic stimulus to the skeleton, which is likely mediated by IGF-1. Manipulation of the microbiome or its metabolites may afford opportunities to optimize bone health and growth.

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Section: Methodsmentioning

confidence: 99%

“…Myocytes also express IGF-1 and ectopic or increased expression of IGF-1 in muscle has been shown to increase bone mass (44)(45)(46). To explore the potential contribution of muscle-derived IGF-1, we isolated RNA from gastrocnemius muscle tissue and measured Igf1 gene expression levels by real-time PCR.…”

Section: (E and F)mentioning

confidence: 99%

Gut microbiota induce IGF-1 and promote bone formation and growth

Yan

Herzog

Tsang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

541

531

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“…[1][2][3] Unexpectedly, accumulating evidence suggests that skeletal muscle is also involved in crosstalk with other organs. 4 The mechanisms for the interaction involve the muscle "secretome," consisting of a variety of growth factors and cytokines that are expressed and secreted by skeletal muscle. 4 Examples of potential mediators of crosstalk in the secretome include IGF-1, myostatin, IL-6, and TNF-a.…”

mentioning

confidence: 99%

“…4 The mechanisms for the interaction involve the muscle "secretome," consisting of a variety of growth factors and cytokines that are expressed and secreted by skeletal muscle. 4 Examples of potential mediators of crosstalk in the secretome include IGF-1, myostatin, IL-6, and TNF-a. [5][6][7][8][9] It is established that these factors are activated and influence the growth and function of skeletal muscles in catabolic conditions, including CKD.…”

mentioning

confidence: 99%

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Can Muscle-Kidney Crosstalk Slow Progression of CKD?

Rondon‐Berrios¹,

Wang²

2014

Journal of the American Society of Nephrology

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Myokines: A central point in managing redox homeostasis and quality of life

Rathor,

Suryakumar

2024

BioFactors

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Redox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle fibers. Skeletal muscle secreted myokines act as a robust modulator for regulating cellular metabolism and redox homeostasis which play a prime role in managing and improving metabolic function in multiple organs. Further, the secretory myokines maintain redox homeostasis not only in muscles but also in other organs of the body via stabilizing oxidants and antioxidant levels. Myokines are also engaged in maintaining mitochondrial dynamics as mitochondria is a central point for the generation of reactive oxygen species (ROS). Ergo, myokines also act as a central player in communicating signals to other organs, including the pancreas, gut, liver, bone, adipose tissue, brain, and skin via their autocrine, paracrine, or endocrine effects. The present review provides a comprehensive overview of skeletal muscle‐secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be discussed that provide a solution for a better quality of life.

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The skeletal muscle secretome: an emerging player in muscle–bone crosstalk

Cited by 114 publications

References 69 publications

Gut microbiota induce IGF-1 and promote bone formation and growth

Gut microbiota induce IGF-1 and promote bone formation and growth

Can Muscle-Kidney Crosstalk Slow Progression of CKD?

Myokines: A central point in managing redox homeostasis and quality of life

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