The skeletal muscle satellite cell: stem cell or son of stem cell?

Myogenic specification of side population cells in skeletal muscle

“…5 B). Similar results were reported in previous works in which Sca-1-positive cells were detected in endothelium and outer layer of blood vessels, but were not detected beneath the basal lamina of skeletal muscle fibers (Zammit and Beauchamp, 2001). These results further confirm that muscle-derived stem cells are distinct cell population from satellite cells and may be associated with the vasculature within muscle.…”

Myogenic specification of side population cells in skeletal muscle

“…5 B). Similar results were reported in previous works in which Sca-1-positive cells were detected in endothelium and outer layer of blood vessels, but were not detected beneath the basal lamina of skeletal muscle fibers (Zammit and Beauchamp, 2001). These results further confirm that muscle-derived stem cells are distinct cell population from satellite cells and may be associated with the vasculature within muscle.…”

Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat

“…On the basis of results of the present and related previous studies, it appears that the distinct pattern of Cx40, Cx43, and Cx45 mRNA expression found during muscle regeneration could correlate with different populations of myogenic precursor cells that have been described to reside in the adult skeletal muscle (5,13,16,25,28,34). By contrast, the Cx39 expression seems to be essential during myoblasts fusion, independently of precursor cell-type-generating myoblasts.…”

New Advanced Technology for Muscular Dystrophy

“…MDSCs are postnatal stem cells identified and distinguished from satellite cells by their relatively low level of commitment to the myogenic lineage . The origin of muscle stem cells isolated from skeletal tissue and their relationship to other stem cells (e.g., muscle satellite cells or blood-derived stem cells) remain unclear, but basic characterization studies have revealed many features of stem cell behavior (Seale et al, 2001;Zammit and Beauchamp, 2001;Deasy and Huard, 2002). Our study presented here reveals that MDSCs have an extended replicative lifetime and a substantial self-renewal capacity that previously has not been demonstrated for postnatal muscle-derived cells.…”

Myogenic specification of side population cells in skeletal muscle

“…5 B). Similar results were reported in previous works in which Sca-1-positive cells were detected in endothelium and outer layer of blood vessels, but were not detected beneath the basal lamina of skeletal muscle fibers (Zammit and Beauchamp, 2001). These results further confirm that muscle-derived stem cells are distinct cell population from satellite cells and may be associated with the vasculature within muscle.…”

Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat

“…On the basis of results of the present and related previous studies, it appears that the distinct pattern of Cx40, Cx43, and Cx45 mRNA expression found during muscle regeneration could correlate with different populations of myogenic precursor cells that have been described to reside in the adult skeletal muscle (5,13,16,25,28,34). By contrast, the Cx39 expression seems to be essential during myoblasts fusion, independently of precursor cell-type-generating myoblasts.…”

New Advanced Technology for Muscular Dystrophy

“…MDSCs are postnatal stem cells identified and distinguished from satellite cells by their relatively low level of commitment to the myogenic lineage . The origin of muscle stem cells isolated from skeletal tissue and their relationship to other stem cells (e.g., muscle satellite cells or blood-derived stem cells) remain unclear, but basic characterization studies have revealed many features of stem cell behavior (Seale et al, 2001;Zammit and Beauchamp, 2001;Deasy and Huard, 2002). Our study presented here reveals that MDSCs have an extended replicative lifetime and a substantial self-renewal capacity that previously has not been demonstrated for postnatal muscle-derived cells.…”

Myogenic specification of side population cells in skeletal muscle

“…5 B). Similar results were reported in previous works in which Sca-1-positive cells were detected in endothelium and outer layer of blood vessels, but were not detected beneath the basal lamina of skeletal muscle fibers (Zammit and Beauchamp, 2001). These results further confirm that muscle-derived stem cells are distinct cell population from satellite cells and may be associated with the vasculature within muscle.…”

Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat

“…On the basis of results of the present and related previous studies, it appears that the distinct pattern of Cx40, Cx43, and Cx45 mRNA expression found during muscle regeneration could correlate with different populations of myogenic precursor cells that have been described to reside in the adult skeletal muscle (5,13,16,25,28,34). By contrast, the Cx39 expression seems to be essential during myoblasts fusion, independently of precursor cell-type-generating myoblasts.…”

New Advanced Technology for Muscular Dystrophy

“…MDSCs are postnatal stem cells identified and distinguished from satellite cells by their relatively low level of commitment to the myogenic lineage . The origin of muscle stem cells isolated from skeletal tissue and their relationship to other stem cells (e.g., muscle satellite cells or blood-derived stem cells) remain unclear, but basic characterization studies have revealed many features of stem cell behavior (Seale et al, 2001;Zammit and Beauchamp, 2001;Deasy and Huard, 2002). Our study presented here reveals that MDSCs have an extended replicative lifetime and a substantial self-renewal capacity that previously has not been demonstrated for postnatal muscle-derived cells.…”