The skeletal muscle satellite cell: stem cell or son of stem cell?

Zammit, Peter S.; Beauchamp, Jonathan R.

doi:10.1046/j.1432-0436.2001.680407.x

Cited by 228 publications

(175 citation statements)

References 104 publications

(146 reference statements)

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“…In vitro, clonal studies have indicated that satellite cells isolated from adult skeletal muscle are heterogeneous in terms of cell size and clonogenic potential (Zammit & Beauchamp 2001). Different subpopulations of satellite cells can also be defined by their behavior and markers.…”

Section: Physiologymentioning

confidence: 99%

Androgen regulation of satellite cell function

Chen¹,

Zajac²,

MacLean³

2005

Journal of Endocrinology

114

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Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose-dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro, the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.

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Section: Physiologymentioning

confidence: 99%

Androgen regulation of satellite cell function

Chen¹,

Zajac²,

MacLean³

2005

Journal of Endocrinology

114

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“…Although the myofibres are postmitotic, a pool of stem cells, termed satellite cells (Mauro, 1961), persists beneath the basal lamina that surrounds each myofibre (reviewed by Zammit and Beauchamp, 2001). During postnatal development, satellite cells divide to provide new myonuclei to the growing muscle fibres before becoming quiescent in mature muscle (Schultz et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

Myogenic Regulatory Factors

青井重善¹,

下竹孝志²,

津田知樹³

et al. 2012

Encyclopedia of Exercise Medicine in Health and Disease

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The myogenic regulatory factor Myf5 is integral to the initiation and control of skeletal muscle formation. In adult muscle, Myf5 is expressed in satellite cells, stem cells of mature muscle, but not in the myonuclei that sustain the myofibre. Using the Myf5 nlacZ/+ mouse, we now show that Myf5 is also constitutively expressed in muscle spindles-stretch-sensitive mechanoreceptors, while muscle denervation induces extensive reactivation of the Myf5 gene in myonuclei. To identify the elements involved in the regulation of Myf5 in adult muscle, we analysed reporter gene expression in a transgenic bacterial artificial chromosome (BAC) deletion series of the Mrf4/Myf5 locus. A BAC carrying 140 kb upstream of the Myf5 transcription start site was sufficient to drive all aspects of Myf5 expression in adult muscle. In contrast, BACs carrying 88 and 59 kb upstream were unable to drive consistent expression in satellite cells, although expression in muscle spindles and reactivation of the locus in myonuclei were retained. Therefore, as during development, multiple enhancers are required to generate the full expression pattern of Myf5 in the adult. Together, these observations show that elements controlling adult Myf5 expression are genetically separable and possibly distinct from those that control Myf5 during development. These studies are a first step towards identifying cognate transcription factors involved in muscle stem cell regulation. D

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“…Mais l'indice de régénération (IR), calculé sur la base du nombre de fibres musculaires exprimant la dystrophine, était très variable en fonction des différentes populations testées. Une telle hétérogénéité dans les populations de cellules souches isolées du muscle squelettique a déjà été soulignée dans d'autres études [6][7][8]. Or, nous avons découvert, au cours de notre évaluation de ces différentes populations de MDSC, que le caractère mâle ou femelle des cellules, rarement pris en compte dans nos études, était un paramètre susceptible d'interférer avec les résultats obtenus in vivo.…”

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