The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men

Snijders, Tim; Verdijk, Lex B.; Smeets, Joey S J; McKay, Bryon R.; Senden, Joan M.; Hartgens, Fred; Parise, Gianni; Greenhaff, Paul L.; Loon, Luc J. C. van

doi:10.1007/s11357-014-9699-z

Cited by 93 publications

(143 citation statements)

References 60 publications

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“…There are numerous lines of evidence indicating resistance exercise, and long-term RT increase the prevalence of muscle satellite cells in humans (Dreyer et al 2006; Mackey and Robinovitch 2006; Petrella et al 2008; Verdijk et al 2009; Snijders et al 2014, 2016; Nederveen et al 2015). Correlative evidence supporting satellite cell–mediated myonuclear addition during human RT-induced myofiber hypertrophy gained traction in the mid-2000s (e.g., Olsen et al 2006; Petrella et al 2006, 2008) and studies reporting modest hypertrophy with no appreciable myonuclear addition (Petrella et al 2006, 2008; Verdijk et al 2009) fueled the concept of reaching a domain ceiling that led to a “demand” for nuclear addition.…”

Section: Muscle Stem (Satellite) Cell Activitymentioning

confidence: 99%

Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy

Bamman

Roberts

Adams

2017

Cold Spring Harb Perspect Med

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Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle atrophy of aging and disease, or to improve athletic performance. While this desired muscle enlargement is a well-known adaptation to resistance exercise training (RT), the mechanistic underpinnings are not fully understood. The purpose of this review is thus to provide the reader with a summary of recent advances in molecular mechanisms—based on the most current literature—that are thought to promote RT-induced muscle hypertrophy. We have therefore focused this discussion on the following areas of fertile investigation: ribosomal function and biogenesis, muscle stem (satellite) cell activity, transcriptional regulation, mechanotransduction, and myokine signaling.

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Section: Muscle Stem (Satellite) Cell Activitymentioning

confidence: 99%

Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy

Bamman

Roberts

Adams

2017

Cold Spring Harb Perspect Med

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“…However, recent work has shown that type II muscle fibre-specific SC content and function declines with increasing age [13,14]. In accordance, it has been hypothesized that the age-related dysfunction of SC plays a major role in impaired muscle regeneration and loss of muscle mass with aging.…”

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

et al. 2016

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Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan. It is well established that SC are essential in skeletal muscle regeneration, and it has been hypothesized that a reduction and/or dysregulation of the SC pool, may contribute to accelerated loss of skeletal muscle mass that is observed with advancing age. The preservation of skeletal muscle tissue and its ability to respond to stimuli may be impacted by reduced SC content and impaired function observed with aging. Aging is also associated with a reduction in capillarization of skeletal muscle. We have recently demonstrated that the distance between type II fibre-associated SC and capillaries is greater in older compared to younger adults. The greater distance between SC and capillaries in older adults may contribute to the dysregulation in SC activation ultimately impairing muscle's ability to remodel and, in extreme circumstances, regenerate. This viewpoint will highlight the importance of optimal SC activation in addition to skeletal muscle capillarization to maximize the regenerative potential of skeletal muscle in older adults.

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“…The addition of new myonuclei to existing muscle fibres represents an essential step in the maintenance and remodelling process of skeletal muscle. Hence, a reduction in SC number and/or function has been hypothesized to play a critical role in the development or progression of muscle fibre atrophy with age …”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men

Nederveen

Joanisse

Snijders

et al. 2016

J cachexia sarcopenia muscle

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114

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BackgroundSkeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age‐related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact on the spatial relationship between SC and muscle fibre capillaries. Secondly, we determined whether this spatial relationship changes in response to a single session of resistance exercise.MethodsMuscle biopsies were obtained from the vastus lateralis of previously untrained young men (YM, 24 ± 3 years; n = 23) and older men (OM, 67 ± 4 years; n = 22) at rest. A subset of YM (n = 9) performed a single bout of resistance exercise, where additional muscle biopsies taken at 24 and 72 h post‐exercise recovery. Skeletal muscle fibre capillarization, SC content, and activation status were assessed using immunofluorescent microscopy of muscle cross sections.ResultsType II muscle fibre SC and capillary content was significantly lower in the YM compared with OM (P < 0.05). Furthermore, type II muscle fibre SC were located at a greater distance from the nearest capillary in OM compared with YM (21.6 ± 1.3 vs. 17.0 ± 0.8 µm, respectively; P < 0.05). In response to a single bout of exercise, we observed a significant increase in SC number and activation status (P < 0.05). In addition, activated vs. quiescent SC were situated closer (P < 0.05) to capillaries.ConclusionsWe demonstrate that there is a greater distance between capillaries and type II fibre‐associated SC in OM as compared with YM. Furthermore, quiescent SC are located significantly further away from capillaries than active SC after single bout of exercise. Our data have implications for how muscle adapts to exercise and how aging may affect such adaptations.

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The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men

Cited by 93 publications

References 60 publications

Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy

Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men

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