The skeletal lesions of acute leukemia

Thomas, Louis B.; Forkner, Claude E.; Frei, Emil; Besse, Byron E.; Stabenau, James R.

doi:10.1002/1097-0142(199005/06)14:3<608::aid-cncr2820140322>3.0.co;2-x

Cited by 158 publications

(63 citation statements)

References 20 publications

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“…The causes of the arthritis in leukemia have been ascribed to leukemic infiltrates in the metaphysial periosteum (2) or hemmorrhages in the joints or periarticular structures (6). Hindmarsh and Emlie-Smith (12), Dresner ( 5 ) , and Bedwell and Dawson (6) have reported finding leukemic infiltrates in the synovial membrane.…”

Section: Discussion Acknowledgmentcontrasting

confidence: 58%

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The arthritis of leukemia

Spilberg

Meyer

1972

Arthritis & Rheumatism

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Arthritis related to the primary disease was detected in 10 of 74 (13.5% patients seen primarily for leukemia [2 of 12 patients with acute (16.6% and 8 of 62 (12.4%) with chronic leukemia]. To these were added 18 ad ditional patients previously diagnosed of having arthritis of leukemia.Clinical analyses of 28 patients with arthritis of leukemia showed that the arthritis of acute leukemia was commonly asymmetric, additive, polyarticular and often part of the initial manifestation of the disease. The arthritis of chronic leukemia was similar t o the acute but was often symmetric and usually appeared as a late manifestation. X-ray films of affected joints were abnormal in 7 patients. Mild hyperuricemia was found in 15.8%, rheumatoid factor in none and antinuclear antibodies in 11% of patients with arthritis of leukemia. Leukemic infiltration of the synovial membrane was found in all 3 of the patients who underwent synovial biopsy and is believed to be the cause of the arthritis.Although arthritis is a known manifestation of acute leukemia (1-5), its occurrence in chronic leukemia is not well recognized ( 6 , 7 ) , and its prevalence has not been reported. This study describes the clinical characteristics and frequency of joint manifestations in a group of patients with chronic and acute leukemia. The incidence of rheumatoid factor, hyperuricemia, antinuclear antibodies and roentgenogram abnormalities was determined. Further, histologic examinations of synovial biopsies were performed in 3 patients.

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Section: Discussion Acknowledgmentcontrasting

confidence: 58%

“…T h e frequency of reported articular manifestations in acute leukemia has varied from 12 to 65% in different series (2,10,11). Our finding of 16.6% falls in the lower range of these widely varying figures.…”

Section: Discussion Acknowledgmentmentioning

confidence: 99%

The arthritis of leukemia

Spilberg

Meyer

1972

Arthritis & Rheumatism

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“…Bone pain occurs in about 50% of patients with acute leukemia, and is more common in ALL (7). Its occurrence in patients in complete remission increases the risk of relapse, infection, or AVNB.…”

Section: Discussionmentioning

confidence: 99%

Avascular Necrosis of Bone: A Complication of Aggressive Therapy for Acute Lymphoblastic Leukemia

et al. 1998

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“…Needle biopsy of the affected knee in 1 patient (Case 3) produced connective ARTHRITIS IN CHILDHOOD LEUKEMIA tissue without leukemic infiltrates. In one series (2), in which postmortem examination of joints from 53 patients dying of leukemia was performed, no mention is made of significant synovial infiltration by leukemic cells. There was also no evidence of gouty arthritis, although gout has been reported in childhood leukemia (9, 10).…”

Section: Discussionmentioning

confidence: 99%

Arthritis as the presenting feature of childhood leukemia

Fink

Windmiller

Sartain

1972

Arthritis & Rheumatism

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Five cases of childhood leukemia are described in which major presentation was arthritis. Three patients had normal hematologic studies when initially examined. Both monoarticular and polyarticular arthritis were seen. Joint swelling was caused by an increase in synovial fluid, but in 1 patient there seemed to be synovial thickening. Presentations and clinical courses were extremely variable and point out the necessity to consider leukemia in the differential diagnosis of children with arthritis.

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The skeletal lesions of acute leukemia

Cited by 158 publications

References 20 publications

The arthritis of leukemia

The arthritis of leukemia

Avascular Necrosis of Bone: A Complication of Aggressive Therapy for Acute Lymphoblastic Leukemia

Arthritis as the presenting feature of childhood leukemia

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