The Size Stability of Alginate Beads by Different Ionic Crosslinkers

Huang, Shu‐Ling; Lin, Yung‐Sheng

doi:10.1155/2017/9304592

Cited by 20 publications

(10 citation statements)

References 31 publications

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“…Chocolate Bead Size. Manufacturing parameters (nozzle diameter, distance of the nozzle from the gelling solution, temperature, polymer solution feed rate, cross-linking agent concentration) and alginate properties (polymer concentration, molecular weight) can be modified to alter or optimize the geometric properties of the beads [34,35].…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Kaltsa

Alibade

Bozinou

et al. 2021

Journal of Food Quality

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The aim of the present study was to evaluate the physical and antioxidant properties of chocolate alginate beads containing Moringa oleifera leaf extract (MLE) produced with ecofriendly solvent extraction technology (Deep Eutectic Solvents). The concentration of MLE incorporated was 0, 2, 4, and 6% w / w , and hardening time for ionotropic gelation with CaCl2 solution was 2, 8, or 20 min. Freshly prepared beads were evaluated for their geometric (area, perimeter, ferret diameter, circularity, roundness), color (CIE L ∗ , a ∗ , and b ∗ and chroma), and antioxidant properties (total phenolic content and percentage inhibition of DPPH• radical). Increasing the MLE concentration resulted in beads smaller in size and more spherical, whereas hardening time only affected their circularity. MLE concentration had also a profound effect on color and antioxidant properties of the beads. As the concentration of MLE increased, the beads appeared lighter and their chroma increased. The radical scavenging activity was ameliorated by the MLE concentration increase for samples hardened for 8 and 20 min, whereas it was unaffected for those at 2 min. The hardening time on the contrary did not affect the inhibition of DPPH• values, regardless of the amount of extract added.

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Section: Resultsmentioning

confidence: 99%

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Kaltsa

Alibade

Bozinou

et al. 2021

Journal of Food Quality

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“…A previous study indicated that alginate beads gelled in Ba +2 solutions were larger than those gelled in Ca +2 solution [20,21]. The microbeads cross linked with Ca +2 (SF6 batch) shrank fastly than remaining curing agents [22]. Based upon pattern of drug release it was clearly understood that drug release is pH dependent.…”

Section: Fig 5: Comparative Dissolution Profile Of Batches From Sf1 mentioning

confidence: 99%

Development and Characterization of Gastro Retentive Mucoadhesive Microbeads Containing Simvastatin With Different Cross Linking Agents

Reddy¹,

Nagabhushanam²,

Reddy³

et al. 2020

Int J App Pharm

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Objective: The aim of the present work was to prepare and examine drug release of the oral controlled release microbeads using different curing agents by emulsification internal ionic gelation technique. Methods: Cross-linked alginate microbeads were prepared with different cross linking agents by using mucoadhesive properties. The formation and compatibility of microbeads were confirmed by compatibility studies. Prepared microbeads evaluated for encapsulated efficiency, micromeritic properties, drug loading, in vitro wash off studies, in vitro dissolution studies, drug release kinetics and stability studies Results: The in vitro drug release was influenced by both type of curing agents and type of polymers and no significant changes in characterization parameters was observed after 3 mo stability studies. The sustained release profile of optimized batch was found to be 99.66±0.18% in comparison to pure drug profile of 28.64±0.02% at 12 h release study. Results of both wash-off and in vitro studies suggests that batch (SF2) prepared with aluminium chloride has shown better mucoadhesive property. Drug release of optimized batch follows zero order with non fickian mechanism according to Korsmeyer-Peppas equation. Conclusion: The data suggest the use of simvastatin mucoadhesive cross linked microbeads to offer the potential for oral controlled drug delivery with improved gastric retention and capable to provide sustained drug release by using cross linking agents.

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“…Structure resolution can also suffer as a result of imperfect [10] skin [10] osteochondral [11,12] ovarian [13] liver [14] neural [15] high resolution potential for high [22] liver [23] vascular [24,25] pancreatic [26] embryonic [27,28] osteochondral [29] flexibility with printing material viscosity; cross-linking parameters: lack of cross-linking can cause spreading of the structure, whereas over-cross-linking can result in lamination and a failure of the entire structure to coalesce [40,60]. Certain cross-linking methods, such as ionic with alginate, can also cause shrinkage that will affect the intended structure's shape [61]. Bearing this in mind, an ideal bio-ink would have sufficient viscosity not to spread upon deposition, and its cross-linking method would be tightly controlled.…”

Section: (B) Structural Stability and Biodegradabilitymentioning

confidence: 99%

Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine

Skeldon

Lucendo‐Villarin

Shu

2018

Phil. Trans. R. Soc. B

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Stem cell technology in regenerative medicine has the potential to provide an unlimited supply of cells for drug testing, medical transplantation and academic research. In order to engineer a realistic tissue model using stem cells as an alternative to human tissue, it is essential to create artificial stem cell microenvironment or niches. Three-dimensional (3D) bioprinting is a promising tissue engineering field that offers new opportunities to precisely place stem cells within their niches layer-by-layer. This review covers bioprinting technologies, the current development of 'bio-inks' and how bioprinting has already been applied to stem-cell culture, as well as their applications for human regenerative medicine. The key considerations for bioink properties such as stiffness, stability and biodegradation, biocompatibility and printability are highlighted. Bioprinting of both adult and pluriopotent stem cells for various types of artificial tissues from liver to brain has been reviewed. 3D bioprinting of stem-cell derived tissues for human regenerative medicine is an exciting emerging area that represents opportunities for new research, industries and products as well as future challenges in clinical translation.This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.

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The Size Stability of Alginate Beads by Different Ionic Crosslinkers

Cited by 20 publications

References 31 publications

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Development and Characterization of Gastro Retentive Mucoadhesive Microbeads Containing Simvastatin With Different Cross Linking Agents

Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine

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