The Size of the Corpus Luteum during Pseudopregnancy and Pregnancy in the Rat

Miyagawa, Noboru; Noguchi, Kunio; Okamoto, Reiko; Saito, Motoi

doi:10.1507/endocrj1954.22.261

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Pepe and Rothchild (20), however, reported that serum progesterone concentrations in long-term hysterectomized rats were higher than those in intact animals. Since the increase in the size of the corpora lutea during pregnancy (22) is associated with an increase in serum progesterone concentrations (23), it could be argued that the absence of a difference in the diameter of the corpora lutea in the intact and long-term hysterectomized pseudopregnant animals also reflects a similarity in luteal activity in these two experimental groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Greef

Dullaart

Zeilmaker³

1976

Endocrinology

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Serum progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations were estimated in intact and hysterectomized pseudopregnant rats. Progesterone concentrations increased significantly from day 2 of pseudopregnancy (PSP) onwards, and a plateau was reached on days 4 and 5. No significant differences in progesterone concentrations between intact and long-term hysterectomized animals were observed until day 10 of PSP. In the intact rats, progesterone concentrations decreased after day 8, but in the hysterectomized rats they remained elevated until days 18-20 of PSP. No differences between FSH concentrations in intact and hysterectomized rats were found. In hysterectomized rats, however, LH concentrations were significantly lower than those in the intact rats on days 2-7 of PSP. When hysterectomy was performed on day 2 of PSP (acute hysterectomy) lower LH concentrations were also found in the hysterectomized animals compared with sham-operated animals. No differences in progesterone concentrations were found between sham-operated controls and acutely hysterectomized animals on days 3-8 of PSP. It was found that LH concentrations in ovariectomized long-term hysterectomized rats were lower than those in ovariectomized, but otherwise intact, animals. In contrast to its effect on tonic LH secretion, long-term hysterectomy had no influence on the surge of LH during the afternoon of proestrus. In both intact and long-term hysterectomized rats the duration of PSP was not significantly altered after transplantation of an ovary under the kidney capsule and the removal of the ovaries in situ. It is concluded that hysterectomy leads to a decreased LH secretion by the pituitary gland, but has no influence on the maximal progesterone concentrations during PSP. The significance of these findings, particularly with regard to the prolongation of PSP after hysterectomy, is discussed.

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Section: Discussionmentioning

confidence: 99%

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Greef

Dullaart

Zeilmaker³

1976

Endocrinology

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Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations

Goldman

Laws

Balchak

et al. 2000

Critical Reviews in Toxicology

144

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In 1996, the US Environmental Protection Agency was given a mandate by Congress to develop a screening program that would evaluate whether variously identified compounds could affect human health by mimicking or interfering with normal endocrine regulatory functions. Toward this end, the Agency chartered the Endocrine Disruptor Screening and Testing Advisory Committee in October of that year that would serve to recommend a series of in vitro and in vivo protocols designed to provide a comprehensive assessment of a chemical's potential endocrine-disrupting activity. A number of these protocols have undergone subsequent modification by EPA, and this review focuses specifically on the revised in vivo screening procedure recommended under the title Research Protocol for Assessment of Pubertal Development and Thyroid Function in Juvenile Female Rats. Background literature has been provided that summarizes what is currently known about pubertal development in the female rat and the influence of various forms of pharmaceutical and toxicological insult on this process and on thyroid activity. Finally, a section is included that discusses technical issues that should be considered if the specified pubertal endpoints are to be measured and successfully evaluated.

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The Size of the Corpus Luteum during Pseudopregnancy and Pregnancy in the Rat

Cited by 2 publications

References 8 publications

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations

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