The size dependant behaviour of particles driven by a travelling surface acoustic wave (TSAW)

Fakhfouri, Armaghan; Devendran, Citsabehsan; Ahmed, Asif; Soria, Julio; Neild, Adrian

doi:10.1039/c8lc01155a

Cited by 57 publications

(38 citation statements)

References 66 publications

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“…The superposition of these fields results in a grid-like pattern of intersecting and perpendicular nodal lines (dotted and dashed lines). [43][44][45] that is perpendicular to the previous field and occurs because the wall bound channel acts as an acoustic waveguide. 45 Therefore, despite the low impedance mismatch between PDMS and the fluid 46 an acoustic field parallel to the propagation of the TSAW develops in the channel with width w = λ SAW .…”

Section: Operation Principlementioning

confidence: 99%

“…42 Recently, traveling surface acoustic waves (T-SAWs) in microfluidics have been used to create time averaged, stationary wave fields that have been used to custom-made pattern acoustic fields to trap particles. [43][44][45] In this paper, we introduce an acoustic method to probe for the first time both the viscous and elastic mechanics of single RBCs, in a microfluidic device. We use a travelling surface acoustic wave (T-SAW) to generate a tuneable, standing acoustic wave field to capture and deform RBCs.…”

Section: Introductionmentioning

confidence: 99%

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Acoustic erythrocytometer for mechanically probing cell viscoelasticity

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Franke

2020

Lab Chip

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We demonstrate an acoustic device to mechanically probe a population of red blood cells at the single cell level. The device operates by exciting a surface acoustic wave in a microfluidic channel creating a stationary acoustic wave field of nodes and antinodes. Erythrocytes are attracted to the nodes and are deformed. Using a stepwise increasing and periodically oscillating acoustic field we study the static and dynamic deformation of individual red blood cells one by one. We quantify the deformation by the Taylor deformation index D and relaxation times τ 1 and τ 2 that reveal both the viscous and elastic properties of the cells. The precision of the measurement allows us to distinguish between individual cells in the suspension and provides a quantitative viscoelastic fingerprint of the blood sample at single cell resolution. The method overcomes limitations of other techniques that provide averaged values and has the potential for high-throughput. † Electronic supplementary information (ESI) available: Movie showing the surface acoustic wave actuated deformation of a red blood cell for stepwise increasing power amplitudes. See

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Section: Operation Principlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acoustic erythrocytometer for mechanically probing cell viscoelasticity

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Franke

2020

Lab Chip

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“…(c,d) Typical BAW devices, which will be introduced in Section 3.2. (e) Vibrated needle manipulation; (f) vibrated geometric substrate manipulation systems [10]. (g) Manipulation by vibrated microbubble induced microflow.…”

Section: Appl Sci 2019 9 X For Peer Review 3 Of 25mentioning

confidence: 99%

“…VAW and VSF are two different vibration-induced physical phenomena. Acoustic radiation force (ARF) and acoustic stream are the two main mechanisms of VAW, referred to as acoustophoresis [10]. Due to the scattering between particles in the medium, an acoustic field forms in the propagation of VAW, where a radiation force exists in the gradient direction [11].…”

Section: Introductionmentioning

confidence: 99%

Advances in Micromanipulation Actuated by Vibration-Induced Acoustic Waves and Streaming Flow

et al. 2020

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The use of vibration and acoustic characteristics for micromanipulation has been prevalent in recent years. Due to high biocompatibility, non-contact operation, and relatively low cost, the micromanipulation actuated by the vibration-induced acoustic wave and streaming flow has been widely applied in the sorting, translating, rotating, and trapping of targets at the submicron and micron scales, especially particles and single cells. In this review, to facilitate subsequent research, we summarize the fundamental theories of manipulation driven by vibration-induced acoustic waves and streaming flow. These methods are divided into two types: actuated by the acoustic wave, and actuated by the steaming flow induced by vibrating geometric structures. Recently proposed representative vibroacoustic-driven micromanipulation methods are introduced and compared, and their advantages and disadvantages are summarized. Finally, prospects are presented based on our review of the recent advances and developing trends.

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“…In contrast, active methods are significantly more robust, capable of on-demand actuation and offer the ability to change functionality ad-hoc, leading to an increased selectivity. To this end, a range of active methods have been developed using magnetic, [23,24] optical, [25,26] electrical [16,27] and acoustic [28][29][30] excitation.Acoustofluidics is the use of acoustic forces to manipulate suspended matter within microfluidics, [31,32] and has the advantage of uniquely combining ease of on-chip integration and simple, yet dextrous establishment of force fields in a noncontact manner. [29,33,34] As a direct result, it has been extensively used to capture, [33,35] pattern, [36][37][38] and sort particles, [15,34,39] cell sonoporation, [40] synthesize nanomaterials, [41] as well as to mix fluids.…”

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confidence: 99%

Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems

et al. 2019

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As the applications of this technology are focused within the clinical and life sciences, a thorough understanding of the associated biological impact imposed by these manipulation techniques is necessary.The desire to manipulate suspended matter within microfluidic systems has inspired a range of techniques both passive [5,19,20] and active. [21,22] Passive approaches rely heavily on the geometry of the microfluidic channels and inertial forces. Flow profiles are altered by the introduction of sudden expansions and contractions, weirs and pillars to impede and divert the flow into desired streamlines. This reliance on the resultant flow profile restricts the flexibility of the chip, being single task specific. In contrast, active methods are significantly more robust, capable of on-demand actuation and offer the ability to change functionality ad-hoc, leading to an increased selectivity. To this end, a range of active methods have been developed using magnetic, [23,24] optical, [25,26] electrical [16,27] and acoustic [28][29][30] excitation.Acoustofluidics is the use of acoustic forces to manipulate suspended matter within microfluidics, [31,32] and has the advantage of uniquely combining ease of on-chip integration and simple, yet dextrous establishment of force fields in a noncontact manner. [29,33,34] As a direct result, it has been extensively used to capture, [33,35] pattern, [36][37][38] and sort particles, [15,34,39] cell sonoporation, [40] synthesize nanomaterials, [41] as well as to mix fluids. [42,43] Although acoustofluidics has been widely accepted as a biocompatible technique, substantiated with cell viability studies; [44][45][46][47][48] there have been no extensive viability studies at elevated frequencies (30-600 MHz). Indeed, typically studies are corroborated with a single viability method, most commonly live/dead staining, [6,[49][50][51] or trypan blue exclusion [52,53] and in some instances proliferation studies (MTT). [36] In contrast to these singular approaches, in passive microfluidic systems in which cells are predominantly subjected to shear forces arising from the flow field, a wide range of multifaceted cell viability studies [54] have been conducted showing, for example, sheardependent regulation of the von Willebrand factor of human umbilical vein endothelial cells [55] and the potential for circulating tumor cell apoptosis at high shear levels. [56] This lack of biological knowledge may result in potential unrecognized adverse effects (i.e., "false positives"), or Acoustic fields are capable of manipulating biological samples contained within the enclosed and highly controlled environment of a microfluidic chip in a versatile manner. The use of acoustic streaming to alter fluid flows and radiation forces to control cell locations has important clinical and life science applications. While there have been significant advances in the fundamental implementation of these acoustic mechanisms, there is a considerable lack of understanding of the associated biological effects on cells. ...

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The size dependant behaviour of particles driven by a travelling surface acoustic wave (TSAW)

Abstract: Travelling surface acoustic waves (TSAW) can cause particles to follow the swirling patterns of acoustic streaming, collect in lines or migrate away from the sound source, this paper examines how particle size determines which one of these behaviours occur.

Cited by 57 publications

References 66 publications

Acoustic erythrocytometer for mechanically probing cell viscoelasticity

Acoustic erythrocytometer for mechanically probing cell viscoelasticity

Advances in Micromanipulation Actuated by Vibration-Induced Acoustic Waves and Streaming Flow

Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems

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