The Site of the Lesion Causing Deafness in Multiple Sclerosis

Barratt, Hilary J.; Miller, David H.; Rudge, Peter

doi:10.3109/01050398809070694

Cited by 26 publications

(9 citation statements)

References 9 publications

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“…The most common type of hearing loss (after normal hearing) for the group of subjects with MS and for the group of control subjects without MS was sensorineural hearing loss. This is the most common type of hearing loss typically reported in articles of both individuals with and without MS. Additionally, this type of hearing loss is consistent with the disease process of MS and prior investigations have suggested that sensorineural hearing loss in individuals with MS is due to swelling and/or scarring in the lower portions of the central auditory pathways or in the cochlear nerve [24,26,28,30,[33][34][37][38] …”

Section: Discussionmentioning

confidence: 48%

Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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Abstract-The purpose of the present investigation was to determine whether differences exist in audiometric hearing status between individuals with and without multiple sclerosis (MS) and between individuals with relapsing-remitting MS (RRMS) and individuals with secondary progressive MS (SPMS). Forty-seven subjects with MS (26 with RRMS and 21 with SPMS) and forty-nine control subjects without MS completed both a comprehensive case-history questionnaire and a conventional hearing evaluation. Statistical analyses, accounting for the potential confounding factors of age, sex, noise exposure, and use of ototoxic medications, revealed significant differences in hearing thresholds between subjects with and without MS at select audiometric test frequencies (p < 0.05). At these audiometric test frequencies, the subjects with MS had poorer hearing thresholds. Additional analyses revealed significant differences in hearing sensitivity at select audiometric frequencies between the subjects with RRMS and the subjects with SPMS, such that those with SPMS had poorer hearing thresholds. These findings have significant clinical implications for practitioners working with patients with MS.

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Section: Discussionmentioning

confidence: 48%

Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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“…Jacobs et al [ 13] and Barratt et al [14] have reported that the lesion did not change over time. Johnson et al [15] Ormerod et al [16] and Costantino et al [17] have reported about the changes of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Barratt et al [14] have hypothesized that demyelinated fibers could transmit impulses, despite the failure of those fibers to transmit impulses at normal velocities, which accounts for the ABR abnormalities. Wc think that the explanation for the difference between recoverable neurological signs and the remaining signs is of importance in the pathophysiological mechanism of MS.…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis Presented Acute Hearing Loss and Vertigo

Sasaki

Ootsuka²,

Taguchi³

et al. 1994

ORL

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A case of multiple sclerosis with acute deafness and dizziness as initial symptoms was reported. The pure-tone audiometry showed a high-frequency sensorineural hearing loss; in the auditory evoked brain stem response (ABR), the left side had a normal peak I with an absence of subsequent peaks. In the equilibrium test, Bruns’ nystagmus was present, and the caloric test demonstrated CP on the left side. MRI disclosed a high-intensity lesion in the cerebellar peduncle (T2-weighted image). With steroid therapy, the deafness and dizziness improved within 10 days, although, after 20 days, the findings of the ABR and caloric test remained unchanged.

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“…However, deafness from intrinsic brainstem disease is very uncommon because hearing is represented bilaterally in the ascending pathways (lateral lemnisci). The more usual explanation for permanent bilateral deafness rarely accompanying acute demyelinating encephalomyelitis, is either associated peripheral labyrinthine damage, for example, zoster involvement of the cochlear nerves (“Ramsay Hunt syndrome plus”)5 or bilateral cochlear nerve root damage at the entry zones 6…”

Section: What Was Goya’s Disease?mentioning

confidence: 99%

Goya’s deafness

Smith

Chitty²,

Williams³

et al. 2008

Pract Neurol

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Francisco Goya (1746-1828), a major Spanish artist, became profoundly deaf aged 46 years, following an acute illness. Despite this, his success continued and he eventually died aged 82 years. His illness is sketchily documented in letters written during his convalescence, describing headache, deafness, tinnitus, unsteadiness and visual disturbance with recovery (apart from deafness) over three months. There was a milder similar illness two years before, suggesting a relapsing condition. Vogt-Koyanagi-Harada syndrome, although previously accepted as Goya's diagnosis, is not supported by the limited evidence. Susac's syndrome or Cogan's syndrome, although both rare, are more likely explanations.

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The Site of the Lesion Causing Deafness in Multiple Sclerosis

Abstract: A patient with multiple sclerosis who developed sequential hearing loss, first on the right, with recovery is discussed. Magnetic resonance imaging demonstrated lesions in the VIII nerve root entry zones which were thought to be responsible for the hearing loss.

Cited by 26 publications

References 9 publications

Audiometric hearing status of individuals with and without multiple sclerosis

Audiometric hearing status of individuals with and without multiple sclerosis

Multiple Sclerosis Presented Acute Hearing Loss and Vertigo

Goya’s deafness

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