The Site of Origin of Lung Cancer and Its Relation to Histological Type

Walter, Julia; Pryce, D. M.

doi:10.1136/thx.10.2.117

Cited by 65 publications

(33 citation statements)

References 7 publications

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“…The peripheral type was thus further divided into 2, intermediate and peripheral: the definition for the intermediate type is a slight modification of Walter's classification, his intermediate tumor having its origin in the small but visible distal part of the segmental bronchus. 31 The 3-type classification is not common but our figure for the central type, 31%, appears slightly lower than that reported by others, 41-47%. 5,7,30,32 The percentages of smokers in the examined cases were high (male 91% and female 60%), compared with 48.3 and 13.6%, respectively, in the Japanese general population, 33 in line with the fact that SCC of the lung is strongly associated with smoking.…”

Section: Discussioncontrasting

confidence: 80%

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

Shimmyo

Hashimoto

Kobayashi

et al. 2006

Intl Journal of Cancer

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The question of whether squamous cell carcinomas (SCCs) arising in different sites of lung are caused by different etiological factors is of obvious importance for prevention, early detection and effective treatment. We here subclassified a large series of resected SCCs (74 cases) into 3 tumor-sites, central (main to segmental bronchi), intermediate (subsegmental to sub-subsegmental) and peripheral (distal to sub-subsegmental bronchi), and examined relationships with p53 mutational spectra and smoking history to provide clues to etiological factors. The rate for GfiA transitions at CpG sites considered to be caused by endogenous mechanism was higher in central (40%) than in intermediate (0%) and peripheral (14%) lesions, in spite of highest percentage of heavy smokers. In contrast, GfiT transversions associated with tobacco smoke carcinogens were most frequent (50%) in the intermediate location, although proportions of heavy smoker's ratio were the same among the locations when confined to p53 mutation cases. In the periphery, other mutations were highest (67%) compared with 33 and 50% in the central and intermediate regions, respectively. Thus, different etiological factors may be playing causal roles in the development of SCCs in different locations of bronchial tree. Furthermore, the results suggest that more extensive study of the influence of tobacco smoke carcinogens on endogenous mechanisms is warranted.

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Section: Discussioncontrasting

confidence: 80%

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

Shimmyo

Hashimoto

Kobayashi

et al. 2006

Intl Journal of Cancer

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“…Table 1 shows the clinical features of primary peripheral lung ACC reported in the English-language literature. We collected information about "peripheral" lung ACC according to the notion that peripheral cancer arises from bronchi smaller than the segmental bronchus (12,13). Reports with- Cl i n i c a l F e a t u r e s o f 1 0 P r i ma r y P e r i p h e r a l L u n …”

Section: Discussionmentioning

confidence: 99%

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

et al. 2007

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Adenoid cystic carcinoma arising from the peripheral lung is rare. Here, we describe adenoid cystic carcinoma that developed in the peripherally in S 9 of the right lower lobe of an 84-year-old woman. Cell blocks prepared from the bronchial wash specimens exhibited the cribriform formation. An immunohistochemical examination of the surgically resected tumor revealed positive thyroid transcription factor-1 and c-kit staining. Exons 9 and 11 of c-kit in tumor cells were not mutated. We compared the clinical features of this patient with those of 10 others described in the English-language literature.

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“…Figures based on surgical specimens give a lower figure for peripheral growths (Spencer, 1962). Walter and Pryce (1955b), however, found about one half of the tumours in an unselected, consecutive surgical series to be peripheral but quoted several other authors to show that the accepted teaching had been that the majority of tumours arose in the major bronchi near the hilum. Certainly in the present series there was a preponderance of more centrally-placed growths.…”

Section: Site Of Tumourmentioning

confidence: 99%

“…There has been a marked lack of uniformity in the classification of histological types of lung cancer, one of the difficulties having been the frequency of structural variants in individual tumours, and another, the interpretation of histological appearances (Walter and Pryce, 1955a). Willis (1960) questioned the validity and value of the histological subdivisions and stated that they were necessarily arbitrary.…”

Section: Site Of Tumourmentioning

confidence: 99%

Bronchogenic Carcinoma in Women

Hanbury¹

1964

Thorax

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The unequal sex incidence of lung cancer, with the decided preponderance of males (Willis, 1960) (1957), and the sex ratio problem was also reviewed by Kirchoff and Rigdon (1959). Reports from other countries include those of Striiuli (1958) and of Giova and Marinelli (1959). In view of the comparatively small total number of female cases studied, it was considered worthwhile to investigate a further series in order to augment statistical information.The present series is composed of 100 consecutive cases from which histological material was examined in the pathology department of this hospital, covering a period between the years 1948 and 1962. Post-mortem examinations were carried out on 43 cases, three of which had had previous pneumonectomies and one a previous lobectomy. The other 57 were collected from the routine surgical histology; this comprised 30 bronchoscopic biopsies, 14 pneumonectomy specimens, nine lobectomy specimens, two thoracotomy biopsies, and two lymph node biopsies. AGE INCIDENCEThe average age of the patients in this series at the time of diagnosis was 58 (to the nearest whole number), the mean figure for the necropsy cases being 60 and that for the surgical cases 56 years.The oldest patient was 75, the youngest 12, and 69 of the 100 cases were aged 55 years or over.These figures show a somewhat higher average age incidence than for bronchogenic carcinoma in general, Willis (1960) having given the mean age of various series as ranging between 45 and 55. Spencer (1962) referred to the later age of the peak incidence of lung cancer in women as having been a universally noted feature, and gave a diagram to show that the peak incidence in women occurred approximately 10 years later than in men. SMOKING HABITSIt is not usually possible to obtain very detailed information in a retrospective survey, and only broad categories of smoking habits can be given here. Out of the 100 cases, 14 were classed as heavy smokers (20 or more cigarettes per day for many years), 24 as medium smokers (10 or more cigarettes per day at some time), 10 as light smokers (less than 10 cigarettes per day at some time), three as very occasional smokers, and 29 as non-smokers. In three cases the only information was that they 'used to smoke', and in 17 cases no information about smoking was obtainable.Todd ( , quoted by Hammond, 1958

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The Site of Origin of Lung Cancer and Its Relation to Histological Type

Cited by 65 publications

References 7 publications

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

Bronchogenic Carcinoma in Women

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