The site and histology of the cancer associated with malignant acanthosis nigricans

Curth, Helen Ollendorff; Hilberg, Albert W.; Machacek, Gerald F.

doi:10.1002/1097-0142(196203/04)15:2<364::aid-cncr2820150220>3.0.co;2-m

Cited by 120 publications

(11 citation statements)

References 32 publications

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“…[67] In comparison to intra-abdominal malignancies, MAN in conjunction with extra-abdominal malignancies, especially gynecological malignancies, is relatively rare. Literature reports six cases of endometrial carcinoma,[89] one case of squamous cell carcinoma of the cervix, three cases of ovarian cancer,[10–12] and one case of uterine cancer have been reported to occur in conjunction with MAN. Early detection of ovarian cancer increases possibilities of successful treatment and survival rate.…”

Section: Discussionmentioning

confidence: 99%

A rare case of malignant acanthosis nigricans in a lady with ovarian cancer

Singh

Rai

2013

Indian Dermatol Online J

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“Tripe palms” or pachydermatoglyphy is a descriptive term of acanthosis nigricans of the palms and is associated with internal malignancy. It often precedes the diagnosis of a new or recurrent tumor. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. In patients with both tripe palms and acanthosis nigricans, gastric carcinoma is the most common followed by lung carcinoma. There are very few reports in the literature of malignant acanthosis nigricans associated with gynecological malignancies. We report this case because of its rarity. A 47-year-old lady presented with lower abdominal swelling and progressive hyperpigmentation which preceded the abdominal swelling by 6 months. On investigations, she was found to have ovarian cancer. The presence of acanthosis nigricans in conjunction with tripe palms in a female patient is highly suggestive of an internal malignancy including an ovarian cancer and demands an extensive search for the hidden ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

A rare case of malignant acanthosis nigricans in a lady with ovarian cancer

Singh

Rai

2013

Indian Dermatol Online J

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“…As supported by numerous cases in the literature, the progressive form of acanthosis nigricans has been considered as a paraneoplastic dermatosis of intra-abdominal malignancies along with tripe palms [2, 3]. Various intra-abdominal malignancies such as gastric, esophageal, pancreatic, and hepatic duct and cyst adenocarcinomas have been associated with MAN [4]. In comparison to intra-abdominal malignancies, MAN in conjunction with extra-abdominal malignancies, especially gynecological malignancies, is relatively rare.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison to intra-abdominal malignancies, MAN in conjunction with extra-abdominal malignancies, especially gynecological malignancies, is relatively rare. Based on the literatures, 6 cases of endometrial carcinoma [5, 6], 1 case [4] of squamous cell carcinoma of the cervix, 3 cases of ovarian cancer [4, 7, 14], and 1 case of uterine cancer [4] have been reported to occur in conjunction with MAN.…”

Section: Discussionmentioning

confidence: 99%

Malignant Acanthosis Nigricans Associated with Ovarian Cancer

Yoon

Kim

2010

Case Rep Dermatol

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Malignant acanthosis nigricans is a cutaneous eruption characterized by symmetric hyperpigmented hyperkeratosis, dermal papillomatosis, and mucosal involvement associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. We present the second case of ovarian cancer in association with two coexisting paraneoplastic dermatoses occurring in a 57-year-old Korean female. The presence of acanthosis nigricans in conjunction with tripe palms in a female patient is highly suggestive of an internal malignancy including an ovarian cancer and demands an extensive search for the hidden ovarian cancer.

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“…The association with bronchial carcinoma was first reported in 1909 [18]. Curth et al [19] extensively reviewed the association of pulmonary neoplasms and acanthosis nigricans. To date, eight cases of adenocarcinoma of the lung and five cases of squamous carcinoma of the lung have been reported in association with acanthosis nigricans [20].…”

Section: Discussionmentioning

confidence: 99%

Acanthosis Nigricans in a Patient with Lung Cancer: A Case Report

Serap

Sever

Yüceege

et al. 2010

Case Reports in Medicine

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Some skin lesions may accompany malignancies. Acanthosis nigricans, one such lesion, is a paraneoplastic dermatosis characterized by hyperpigmented and velvety verrucose plaques observed as symetric eruptions. With this report, we aim to present a rare case of concomitant lung cancer and acanthosis nigricans. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. A 65-year-old patient who had hyperpigmented, hypertrophic and symmetric verrucose lesions at the flexor surfaces of the lower and upper extremities, face, palms and the axillary region. Thoracic computed tomography demonstrated a hypodense mass lesion with a dimension of 5 × 5.5 cm at the center of basal segment bronchi of the left pulmonary lobe. Fiberoptic bronchoscopy showed that the access to the lower left lobe was almost completely obstructed by the endobronchial lesion. The result of the histopathologic examination of the endobronchial tissue biopsy was reported as non-small cell (adenocarcinoma) lung cancer. Result of the histopathologic analysis of the punch biopsy of the skin lesions was reported as acanthosis nigricans .There are no pathognomonic dermatological findings for lung cancer. In conclusion, there are skin lesions that accompany lung cancer and we believe that these should be considered for differential diagnosis.

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The site and histology of the cancer associated with malignant acanthosis nigricans

Cited by 120 publications

References 32 publications

A rare case of malignant acanthosis nigricans in a lady with ovarian cancer

A rare case of malignant acanthosis nigricans in a lady with ovarian cancer

Malignant Acanthosis Nigricans Associated with Ovarian Cancer

Acanthosis Nigricans in a Patient with Lung Cancer: A Case Report

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