volume 5, issue 3, P144-150 2013
DOI: 10.18632/aging.100544
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Philip I. Merksamer, Yufei Liu, Wenjuan He, Matthew D. Hirschey, Danica Chen, Eric Verdin

Abstract: Reactive oxygen species (ROS) are a family of compounds that can oxidatively damage cellular macromolecules and may influence lifespan. Sirtuins are a conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases that regulate lifespan in many model organisms including yeast and mice. Recent work suggests that sirtuins can modulate ROS levels notably during a dietary regimen known as calorie restriction which enhances lifespan for several organisms. Although both sirtuins and ROS …

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