The Single Testis: Paternity After Presentation as Unilateral Cryptorchidism

LEE, PETER A.; Coughlin, Michael T.

doi:10.1097/00005392-200210020-00005

Cited by 14 publications

(14 citation statements)

References 12 publications

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“…Lee and co-authors, who performed a retrospective review of medical records and sent a detailed questionnaire to patients, concluded that unilateral cryptorchid men have a normal paternity rate [Lee et al, 1996]. It should be noted that in this study the authors did not rely upon the results of testicular biopsies.…”

Section: Paternity As a Fertility Indicator?mentioning

confidence: 94%

Is Hormonal Treatment of Congenital Undescended Testes Justified A Debate

Hadžiselimović¹

2019

Sex Dev

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Abnormal germ cell development in cryptorchidism is not a result of a congenital dysgenesis but is preceded by a hormone imbalance and perturbation in germ cell-specific gene expression during abrogated mini-puberty. Adequate treatment with low doses of GnRHa enables 86% of men to achieve a normal sperm count and, most importantly, prevent development of azoospermia. GnRHa treatment induces a significant transcriptional response, including protein coding genes involved in pituitary development, the hypothalamic-pituitary-gonadal axis, and testosterone synthesis. Furthermore, hormonal treatment to achieve epididymo-testicular descent as a first choice of treatment of cryptorchidism has a long tradition in Europe. It eliminates the necessity of subsequent surgery. Moreover, in the cases of non-responders it facilitates orchidopexy and contributes considerably to a reduced incidence of unilateral and the more serious bilateral complete post-surgical testicular atrophy.

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Section: Paternity As a Fertility Indicator?mentioning

confidence: 94%

Is Hormonal Treatment of Congenital Undescended Testes Justified A Debate

Hadžiselimović¹

2019

Sex Dev

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“…Kombi nationstherapie einen höheren Wirkungs grad als die isolierte Gabe von LHRH Analoga oder HCG. Bis heute gibt es aber keine randomisierten Studien, die die Überlegenheit des einen oder anderen Vorgehens darlegen [24].…”

Section: Leitliniengerechte Therapieunclassified

“…Eine Möglichkeit, den Hoden in Bezug auf Fertilität zu beurteilen, ist der "Tubu lar Fertility Index" (TFI [24]. Des Weiteren offen barte sich auch kein zeitlich signifikanter Unterschied bis zur Konzeption -auch ein wichtiger Parameter zur Beurteilung der Fertilität.…”

Section: Introductionunclassified

Hodenhochstand und Infertilität unter besonderer Berücksichtigung der interdisziplinären Leitlinie

Mathers

Degener

Roth

2011

Urologe

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Cryptorchidism is the most common genital disorder in boys. Early-born boys are affected in up to one third of the cases, while about 2-5% of full-term newborns suffer from at least one undescended testicle. As a result of short-term endogenous testosterone secretion after birth the prevalence decreases to 1-2% after 3 months. According to most studies, watchful waiting after 6 months is not justified because after this time spontaneous testicular descent only very rarely occurs. Even though the effects of testicular development and fertility in undescended testis have been extensively examined, the only fact that remains certain is that approximately 90% of untreated men with bilateral cryptorchidism develop azoospermia. The remaining scenarios of cryptorchidism (unilateral, ectopic, inguinal, treated or not treated) exhibit unpredictable fertility and likelihood of fatherhood.

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“…8 Furthermore, another study failed to show a difference in paternity among men with monorchidism owing to an absent or removed testis, men with unilateral cryptorchidism treated with orchiopexy in childhood and controls. 9 In those patients with decreased fertility from bilateral disease, successful pregnancy is possible using testicular sperm extraction and intracytoplasmic sperm injection. 10 …”

Section: Cryptorchidismmentioning

confidence: 99%