The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

Zhang, Chuan; Yuan, Gao; Cheng, Zhen; Xu, Min; Hou, Lisha; Wei, Fan

doi:10.1016/j.hlc.2008.12.002

Cited by 18 publications

(7 citation statements)

References 22 publications

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“…This replicates the findings by Zhang et al [26] in a population of an entirely different ethnicity (Han Chinese vs. Caucasians), further strengthening the evidence for a true association with lone AF.…”

Section: Discussionsupporting

confidence: 89%

“…As mentioned above, Zhang et al [26] screened KCNJ5 in 186 lone-AF patients in a Chinese Han population. They reported that rs6590357 was in slight LD with rs7118824.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been reported that specifically for KCNJ5 two SNPs (rs6590357 and rs7118833) were associated with lone AF in a Chinese Han population [26]. …”

Section: Introductionmentioning

confidence: 99%

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Common Polymorphisms in <i>KNCJ5</i> Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Jabbari

Olesen²,

Holst³

et al. 2011

Cardiology

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Objectives: The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese. Methods: We sequenced the coding region and splice site of KCNJ2, KCNJ3 and KCNJ5 in 187 early-onset lone-AF patients screening for mutations and counting SNP frequencies for the two noted SNPs in KCNJ5. Results: No mutations were found in KCNJ2, KCNJ3 or KCNJ5. Both genotype distribution and allele frequencies of the SNPs rs6590357 and rs7118824 significantly differed between the AF and control group (p_genotype = 0.0067, p_allele = 0.0021 and p_genotype = 0.014, p_allele = 0.0101, respectively). On allele level, the OR for lone AF for rs6590357 was 1.77 (95% CI 1.16–2.73, p = 0.009) and for rs7118824 it was 1.71 (95% CI 1.13–2.57, p = 0.01) in a model adjusted for age and gender. Conclusions: Our findings indicate that rs6590357 and rs7118824 in KCNJ5 are associated with early-onset lone AF in Caucasians. No mutations were found in the exon or splice site of KCNJ2, KCNJ3 or KCNJ5.

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Section: Discussionsupporting

confidence: 89%

“…As mentioned above, Zhang et al [26] screened KCNJ5 in 186 lone-AF patients in a Chinese Han population. They reported that rs6590357 was in slight LD with rs7118824.…”

Section: Discussionmentioning

confidence: 99%

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Common Polymorphisms in <i>KNCJ5</i> Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Jabbari

Olesen²,

Holst³

et al. 2011

Cardiology

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“…This resulted in KCNC4 expression being up-regulated, IKAch being enhanced, and APD being shortened. However, a previous study (41) reported that in patients with persistent AF, the IKAch current density decreased by about 50 %, along with a decrease in the regulating miRNA level. A decrease in the IKAch density may result in an increase in the atrial muscle excited heterogeneity, which may promote re-entrance and trigger the occurrence (38,42).…”

Section: Ikachmentioning

confidence: 86%

Treating atrial fibrillation with radiofrequency ablation to reverse changes in microRNAs regulating the ion-channel proteins

Yue¹,

Li²,

Xu³

et al. 2021

BLL

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OBJECTIVE: To investigate the possible molecular mechanisms of radiofrequency ablation (RFA) for treating atrial fi brillation (AF) and the microRNA (miRNA) target for intervention in the future. METHODS: We examined the changes in miRNAs regulating the atrial ion-channel proteins across the whole genome. We compared fi ndings from 90 AF patients with those from 90 healthy subjects before RFA and three months after RFA. RESULT: Twenty-one miRNAs regulating ion-channel proteins were differentially expressed more than tenfold, and the fi ndings were completely reversed after RFA as compared with the pre-RFA results. The colonial regulating effects of miRNAs regulating the outward K + current channels such as those for the ultra-rapid delayed rectifi er potassium current (Ikur), voltage-dependent delayed rectifi er potassium current (Ikr), and delayed rectifi er potassium channel current (Iks) were more unanimous and stronger, while this was not the case for miRNAs regulating the L-type Ca 2+ current and INa current channels. Generally, miR-1266 levels were increased in the blood but down-regulated in the rheumatic atrial tissue, while a dual luciferase test indicated that SCN5A was the direct target gene of miR-1266. CONCLUSION: Using RFA to treat AF may have an impact via reversing the changes in miRNAs regulating the ion-channel proteins, especially for outward K+ current channels such as Ikur, Ikr, and Iks, which may play a major role in electrical remodeling in AF. It may be that miR-1266 is an antiarrhythmic miRNA and an AF intervention target in the future (Tab. 2, Fig. 4, Ref. 46).

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“…Studies of the underlying genetic factors of atrial fibrillation have identified two KCNJ5 gene mutations, rs6590357 and rs7118833, associated with this cardiac event [13]–[14]. Further studies of KCNJ5 gene variants have found that two somatic mutations (G151R and L168R) and two germline mutations (T158A and G151E) are associated with APA and FH-III, respectively [15]–[19].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variations in the KCNJ5 Gene in Primary Aldosteronism Patients from Xinjiang, China

Zhang

et al. 2013

PLoS ONE

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BackgroundPrimary aldosteronism (PA) is the most common endocrine form of secondary hypertension, and one of the most common subtypes of sporadic PA is aldosterone-producing adenoma (APA). Recently, two somatic mutations of the KCNJ5 gene were implicated in APA, and two germline mutations were associated with familial hyperaldosteronism III.ObjectivesThis case-control study was designed to investigate the relationship between genetic variations in the KCNJ5 gene and sporadic PA patients in Xinjiang, China.MethodsFive common single nucleotide polymorphisms (SNPs) of the KCNJ5 gene (rs6590357, rs4937391, rs3740835, rs2604204, and rs11221497) were detected in patients with sporadic PA (n = 235) and essential hypertension (EH; n = 913) by the TaqMan polymerase chain reaction method.ResultsThe EH group and the PA group showed significant differences in the distributions of genotypes and alleles of rs4937391 and rs2604204 in total and male subjects (P<0.05), as well as rs3740835 in male subjects (P<0.05). However, only the association between the rs2604204 genotype and male sporadic PA remained significant after Bonferroni’s correction (P<0.01). Furthermore, logistic regression analysis demonstrated that the CC genotype of rs2604204 was a risk factor for male patients with sporadic PA, after adjusting for age and body mass index (odds ratio = 2.228, 95% CI: 1.300–3.819, P = 0.004).ConclusionThe genetic variant rs2604204 of KCNJ5 is associated with sporadic PA in Chinese males, suggesting that KCNJ5 may be involved in the pathogenesis of sporadic PA in these particular patients.

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The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population

Cited by 18 publications

References 22 publications

Common Polymorphisms in <i>KNCJ5</i> Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Common Polymorphisms in <i>KNCJ5</i> Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Treating atrial fibrillation with radiofrequency ablation to reverse changes in microRNAs regulating the ion-channel proteins

Genetic Variations in the KCNJ5 Gene in Primary Aldosteronism Patients from Xinjiang, China

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