“…Ferroptosis in ZD2767P-CPG2-US therapy suggested a strategy against resistant cancers, since inducing nonapoptotic cell death can combat chemoresistance (25). A cancer is heterogeneous with multiple cell subpopulations with distinct features (26)(27)(28). Ferroptosis bypasses the apoptosis pathway to lead to cell death in certain subpopulations, and offsets the apoptosis insufficiency in other subpopulations, thereby deactivating abundant cancer cells.…”