The simultaneous assay of riboflavin 5-phosphate sodium and other water-soluble vitamins in liquid multivitamin formulations by liquid chromatograph

Lam, Fuk-Luen; Lowande, A.

doi:10.1016/0731-7085(88)80033-5

Cited by 16 publications

(3 citation statements)

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“…The first peak was found to appear after 1.8 minutes (t r =1.8 min) and it corresponds to RbP, while the second peak belongs to Rb, with the retention time of 5.3 minutes (t r =5.3 min). This is in agreement with prior work by Lam and Lowande [32], where the composition of 70 % riboflavin-5'-phosphate sodium salt was shown to be a mixture of 10 % riboflavin and 60 % phosphate salt. It is well known that RbP is converted to Rb by acidic or alkaline phosphatases due to its structural similarity to the nucleosides [32].…”

Section: Conversion Of Rbp To Rb In the Corneasupporting

confidence: 93%

“…This is in agreement with prior work by Lam and Lowande [32], where the composition of 70 % riboflavin-5'-phosphate sodium salt was shown to be a mixture of 10 % riboflavin and 60 % phosphate salt. It is well known that RbP is converted to Rb by acidic or alkaline phosphatases due to its structural similarity to the nucleosides [32]. In order to confirm that this is happening in the cornea during the permeability test, the RbP solution was mixed with the homogenized parts of the cornea and its concentration was measured after 2 hours using HPLC.…”

Section: Conversion Of Rbp To Rb In the Corneasupporting

confidence: 93%

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Delivery of Riboflavin-5′-Monophosphate Into the Cornea: Can Liposomes Provide Any Enhancement Effects?

Kandžija

Khutoryanskiy

2017

Journal of Pharmaceutical Sciences

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Keratoconus is a progressive condition caused by the thinning of the cornea, which eventually deforms the front surface of the eye into a cone shape leading to ghosting, multiple images, glare, and several other vision problems. Currently, keratoconus is treated with UV-induced riboflavin (Rb)-mediated collagen cross-linking, which requires a physical removal of the corneal epithelium under topical anesthesia. This study reports the penetration of Rb and its more water-soluble form, riboflavin-5'-monophosphate (RbP), into the bovine cornea ex vivo. Using ex vivo bovine corneal tissues and 0.8 mg/mL drug solutions in phosphate buffer, it was established that RbP penetration into the cornea within 3 h of diffusion experiment was greater (17.3 ± 0.8 μg) compared with Rb (10.4 ± 4.2 μg). In the cornea, RbP was found to convert to Rb, which is mediated with enzymes present in this tissue. Several formulations including the conventional and propylene glycol-containing liposomes with encapsulated RbP have been developed, and their effect on the drug penetration into the bovine cornea was evaluated. Encapsulation of RbP into the liposomes did not provide any statistically significant improvement in the penetration of RbP into the cornea.

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Section: Conversion Of Rbp To Rb In the Corneasupporting

confidence: 93%

Section: Conversion Of Rbp To Rb In the Corneasupporting

confidence: 93%

Delivery of Riboflavin-5′-Monophosphate Into the Cornea: Can Liposomes Provide Any Enhancement Effects?

Kandžija

Khutoryanskiy

2017

Journal of Pharmaceutical Sciences

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“….., ,00 mg* cloridrato de piridoxina """""""""""""'"'''''''0'''''0''''' 5,00 mg* nicotinamida .. """""'"'''''' """"'0 ooo""," oo" o",,,,,,,,,, 50,00 mg pantenol o 25,00 mg* tetracetato de etilenodiamina dissódico 0,1O mg cloretO de benzalcônio 0"''''''''''''''''''''''''''''''''''''''''''0'''' 0,10 mg hidroxicobalamina , """"""""0"""""""…”

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Doseamento da vitamina B6 por espectrofotometria derivada no ultravioleta

Consiglieri¹

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Helou pelo apoio durante a realização deste trabalho. À Farmalídia pelas amostras fornecidas. À Fundação do Remédio Popular (FURP) pelas substâncias químicas de referência e matérias-primas cedidas. À A.W.A pela editoração eletrônica do texto e impressão a laser. À Moema R. dos Santos pela revisão das referências bibliográficas. Aos demais colegas dos Setores de Farmacotécnica e Controle de Qualidade. Aos meus amigos Alexander, Walter e André pela paciência, apoio e incentivo. Aos meus pais, Dante e Eisa, por todo amor. A todas as pessoas que direta e indiretamente colaboraram para a realização deste trabalho.

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Methods of control and standardization of drugs containing water-soluble vitamins (a review)

Luttseva

Maslov

1999

Pharm Chem J

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The simultaneous assay of riboflavin 5-phosphate sodium and other water-soluble vitamins in liquid multivitamin formulations by liquid chromatograph

Cited by 16 publications

References 1 publication

Delivery of Riboflavin-5′-Monophosphate Into the Cornea: Can Liposomes Provide Any Enhancement Effects?

Delivery of Riboflavin-5′-Monophosphate Into the Cornea: Can Liposomes Provide Any Enhancement Effects?

Doseamento da vitamina B6 por espectrofotometria derivada no ultravioleta

Methods of control and standardization of drugs containing water-soluble vitamins (a review)

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