The simultaneous action of acute paradoxical sleep deprivation and hypothyroidism modulates synaptosomal ATPases and acetylcholinesterase activities in rat brain

Todorović, Jovan; Dinčić, Marko; Krstić, Danijela; Čolović, Mirjana B.; Ostojic, Jelena Nesovic; Kovačević, Sanjin; Lopičić, Srđan; Spasić, Svetolik; Brkić, Predrag; Milovanovic, A.

doi:10.1016/j.sleep.2023.03.002

Cited by 1 publication

(1 citation statement)

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“…Acetylcholinesterase (AChE) enzyme activity that is responsible for metabolism of acetylcholine, the important cholinergic neurotransmitter involved in learning and memory, remarkably increased hypothyroidism in both animal studies and clinical setting; in this regard, Amirahmadi et al demonstrated the beneficial effect of folic acid in hypothyroid rats caused by PTU, which attributed to balance between oxidative/antioxidant mediators along with decrease activity of acetylcholinesterase (Amirahmadi et al, 2021). Moreover, another similar study has been associated with hypothyroidism and changing the brain activity of some important enzymes implicated in learning and memory including acetylcholinesterase and adenosine triphosphatase (ATPases) (Todorović et al, 2023). To support, another study illustrated the direct effect of thyroxin (T4) on metabolism of acetylcholine and treatment of hypothyroidism with thyroxin (T4); in addition to donepezil, acetylcholinesterase inhibitors demonstrated much better results, which imply that hypothyroidism significantly reduced acetylcholine content more likely to decrease the activity of AChE (Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring

Kakhki,

Goodarzi,

Abbaszade‐Cheragheali

et al. 2023

Intl J of Devlp Neuroscience

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IntroductionThe present study aimed to analyse both neurobehavioural and biochemical results of neonates born of mothers exposed to different doses of lithium along with the groups that received lithium at the highest dose with folic acid as a preventive treatment.Materials and methodsMale and female rats were mated in separate cages, and pregnant rats were divided into eight first group as (1) vehicle; (2) propylthiouracil (PTU)‐induced hypothyroidism; (3–4) received two different doses of lithium carbonate (15 and 30 mg/kg); (5–7) the highest doses of lithium (30 mg/kg) plus three different doses of folic acid (5, 10 and 15 mg/kg); and (8) received just folic acid (15 mg/kg). All treatments were dissolved in drinking water and continued until delivery, followed by returning to a regular diet without treatment.ResultsLithium (30 mg/kg) disrupts both behavioural and biochemical markers, including TSH, T3 and T4 as measuring indicators to assess thyroid function, IL‐10 and TNF‐α as anti‐inflammatory and inflammatory agents, respectively, malondialdehyde as an oxidative stress marker, alongside SOD, and catalase activity as antioxidant indicators. Besides, folic acid, almost at the highest dose (15 mg/kg), attenuated memory impairement and anxiety‐like behaviour caused by lithium. Moreover, the groups treated with folic acid alone in comparison with vehicles demonstrated higher levels of antioxidant and anti‐inflammatory indicators.ConclusionAccording to the results, prenatal exposure to a high dose of lithium (30 mg/kg) leads to foetal neurodevelopmental disorder and growth restriction through various mechanisms more likely attributed to hypothyroidism, which means it should be either prohibited or prescribed cautiously during pregnancy.

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Section: Introductionmentioning

confidence: 99%