The Simple Isoquinolines

Shamma, Maurice; Moniot, Jerome L.

doi:10.1007/978-1-4615-8819-1_1

Cited by 2 publications

(1 citation statement)

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“…Hexahydrobenzo[ c ]phenanthridine-type alkaloids ( Figure 1 ), which are constituted by tetrahydroisoquinoline motifs, are commonly present in papaverous plants, which show a wide range of biological activities such as antitumor, antinociceptive, and antiserotoninergic properties. 1 Even though several synthetic approaches for this class of molecules are reported, 2 virtually, all of them involve multiple steps to reach their core skeletons. Hence, the development of an efficient and one-step synthesis protocol to access these structural scaffolds and their analogues is of immense interest.…”

Section: Introductionmentioning

confidence: 99%

Regio- and Stereoselective Synthesis of the Core Structure of Hexahydrobenzo[c]phenanthridine Alkaloids via Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation of Cyclic Alkenes with Benzamides

2020

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A highly stereo- and regioselective synthesis of the core skeleton of hexahydrobenzo[ c ]phenanthridine-type alkaloids is reported herein for the first time. A wide range of substrate scope, excellent functional group tolerance, and good to excellent yields were observed. This protocol gives very concise and efficient access to the core skeleton of chelidonine alkaloids as compared to the earlier approaches.

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Section: Introductionmentioning

confidence: 99%