The simian crease: Relationship to various genetic disorders

Abstract

The creases of the palm have been of interest for clinicians, anthropologists, and palmists for hundreds of years, but the variations in them have only been studied during the past 50 years. The simian crease, aptly named for its resemblance to the palmar creases of nonhuman simian primates, has received recognition clinically and anthropologically owing to its abnormal appearance and confounding cytogenetic etiology. Given the rarity of these palmar creases but also their usefulness in diagnosing congenital disorders, discussion of cases of those disorders could provide clinicians with further helpful diagnostic knowledge. This review of the literature focuses on the history, embryology, genetic and hereditary origins, and clinical significance of simian creases for the benefit of the diagnosing clinician.

Fingerprint patterns in relation to an altered neurodevelopment in patients with autism spectrum disorder

“…Dermatoglyphic pattern formation and differentiation are complex processes. Deviations in their formation have been described in several mental disorders and behaviors such as intellectual disability (Rosa et al., 2001; Sadanandan & Ushadevi, 2016), autism (Kazemi et al., 2017; Walker, 1997), schizophrenia (Bracha et al., 1991; Golembo‐Smith et al., 2012; Kalmady et al., 2015), bipolar disorder (Shrivastava et al., 2016), Alzheimer´s diseases (Weinreb, 1985), and genetic syndromes (Preus & Fraser, 1972) such as trisomy (Purvis‐Smith, 1972; Sunilkumar, 2014; Wahl et al., 2019), predispositions for dyslexia (Jamison, 1988), or hyperactivity (Anindya Sariza et al., 2021). Over the last years, a tendency of using biological markers in mental disorders has been observed, focusing on early prenatal brain damage.…”