The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease

Zhu, Rongyan; Qi, Xiuyan; Liu, Cuiping; Wang, Dong‐Xin; Li, Li; Liu, Xiaofeng; Hou, Yongge; Su, Xuantao; Lin, Huiqian

doi:10.31083/j.jin.2020.02.1151

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…In addition to STAT3 responsible for cellular processes, the changes of cleaved caspase-3 and MMP-9 are critical for the biological processes of cells. Caspase-3 can be cleaved and activated via both caspase-9 and caspase-8 initiator caspases to trigger apoptosis (Shalini et al 2015 ; Zhu et al 2020 ). Previous reports show that the inhibition of STAT3 signaling increases the activation of caspase-9, caspase-3, and caspase-7 (Sun et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway

Zhang

Guo

et al. 2021

Biochem Genet

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In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) present a unique aggressive phenotype and have a passive response to the inflammatory microenvironment, which are critical for the disease’s progression. KDM4B, as a histone demethylase, functions as an oncogenic factor in many cancers and is implicated in osteoclastogenesis as well as pro-inflammatory cytokine release in inflammatory diseases. However, the effects of KDM4B on RA FLS have not been reported. To investigate this issue, our study determined the expression of KDM4B in RA FLS using RT-qPCR and western blot. The effects of KDM4B on RA FLS viability, apoptosis, migration, and invasion were detected by MTT, flow cytometry, transwell migration, and invasion assays. Furthermore, the interaction of KDM4B with STAT3 signaling was studied by western blot, MTT, flow cytometry, transwell migration, and invasion assays. The experimental results showed that KDM4B expression was upregulated in RA synovial tissues and FLS as compared to healthy control tissues and normal FLS. Knockdown of KDM4B obviously suppressed RA FLS viability, migration and invasion, and induced apoptosis. In addition, knockdown of KDM4B in RA FLS decreased the expression of p-STAT3 and MMP-9 but increased cleaved caspase-3 expression compared with the control group. Moreover, KDM4B overexpression could promote cell growth, migration and invasion, and suppress apoptosis in RA FLS by activating STAT3 signaling. Therefore, these findings provide new insight for understanding the pathogenesis of RA and indicate that KDM4B may have a potential to be an effective therapeutic target for RA.

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Section: Discussionmentioning

confidence: 99%

KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway

Zhang

Guo

et al. 2021

Biochem Genet

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“…miR‐135b‐5p plays a neuroprotective role by targeting GSK3β3 34 , 35 and can also regulate neuroectoderm formation through TGF‐β/BMP signaling 36 ; miR‐7a‐5p, which is widely found in zebrafish, human, and mouse, plays a regulatory role in nerve development, nerve injury, central nervous system tumors, and Parkinson's disease, by targeting EGFR, RAF1, KLF4, PARP, SP1, and PI3K 37 ; overexpression of miR‐217‐5p protects against oxygen‐glucose deprivation‐induced neuronal injury 38 ; miR‐211‐5p has been shown to regulate the progression of Alzheimer's disease in rat animal models. 39 Some related lncRNA–miRNA interactions have been preliminarily identified and validated in tumor models such as lncRNAGAS8‐AS1‐miR‐135b‐5p. Moreover, lncRNAGAS5‐miR‐135b‐5p has been shown to interfere with cancer progression.…”

Section: Discussionmentioning

confidence: 99%

Identification and coregulation pattern analysis of long noncoding RNAs following subacute spinal cord injury

Wang

et al. 2021

Journal Orthopaedic Research

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Long noncoding RNAs (lncRNAs) have been demonstrated to play critical regulatory roles in posttranscriptional and transcriptional regulation in eukaryotic cells.However, the characteristics of many lncRNAs, particularly their expression patterns in the lesion epicenter of spinal tissues following subacute spinal cord injury (SCI), remain unclear. In this study, we determined the expression profiles of lncRNAs in the lesion epicenter of spinal tissues after traumatic SCI and predicted latent regulatory networks. Standard Allen's drop surgery was conducted on mice, and hematoxylin and eosin staining was used to observe the damaged area. Highthroughput sequencing was performed to identify the differential expression profiles of lncRNAs. Quantitative real-time polymerase chain reaction was conducted to evaluate the quality of the sequencing results. Bioinformatics analyses, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, coexpression analysis, and protein-protein interaction analysis, were performed.Targeted binding of lncRNA-miRNA-mRNA was predicted by TargetScan and miRanda. A total of 230 differentially expressed lncRNAs were identified and preliminarily verified, and some potential regulatory networks were constructed. These findings improve our understanding of the mechanisms underlying subacute SCI; differentially expressed lncRNAs are closely involved in pathophysiological processes by regulating multiple pathways. Further studies are essential for revealingThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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“…Moreover, mir-204-5p was also involved in the pathophysiological process of aortic valve calcification, which shared many common characteristics of atherogenesis (31,32). The microRNA miR-211-5p could inhibit cortical neuron differentiation and survival and strengthen oxidative stress in Alzheimer's disease (33,34). In osteoarthritis, miR-211-5p contributed to chondrocyte differentiation by suppressing Fibulin-4 expression (35,36).…”

Section: Discussionmentioning

confidence: 99%

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

Yan

Zhu

et al. 2021

Front. Cardiovasc. Med.

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Background: Coronary artery disease (CAD) is the leading cause of cardiovascular death. The competitive endogenous RNAs (ceRNAs) hypothesis is a new theory that explains the relationship between lncRNAs and miRNAs. The mechanism of ceRNAs in the pathological process of CAD has not been fully elucidated. The objective of this study was to explore the ceRNA mechanism in CAD using the integrative bioinformatics analysis and provide new research ideas for the occurrence and development of CAD.Methods: The GSE113079 dataset was downloaded, and differentially expressed lncRNAs (DElncRNAs) and genes (DEGs) were identified using the limma package in the R language. Weighted gene correlation network analysis (WGCNA) was performed on DElncRNAs and DEGs to explore lncRNAs and genes associated with CAD. Functional enrichment analysis was performed on hub genes in the significant module identified via WGCNA. Four online databases, including TargetScan, miRDB, miRTarBase, and Starbase, combined with an online tool, miRWalk, were used to construct ceRNA regulatory networks.Results: DEGs were clustered into ten co-expression modules with different colors using WGCNA. The brown module was identified as the key module with the highest correlation coefficient. 188 hub genes were identified in the brown module for functional enrichment analysis. DElncRNAs were clustered into sixteen modules, including seven modules related to CAD with the correlation coefficient more than 0.5. Three ceRNA networks were identified, including OIP5-AS1-miR-204-5p/miR-211-5p-SMOC1, OIP5-AS1-miR-92b-3p-DKK3, and OIP5-AS1-miR-25-3p-TMEM184B.Conclusion: Three ceRNA regulatory networks identified in this study may play crucial roles in the occurrence and development of CAD, which provide novel insights into the ceRNA mechanism in CAD.

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The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease

Cited by 10 publications

References 25 publications

KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway

KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway

Identification and coregulation pattern analysis of long noncoding RNAs following subacute spinal cord injury

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

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