The significant association of CCND1 genotypes with colorectal cancer in Taiwan

Abstract

Colorectal cancer, one million cases of diagnosis worldwide annually, is one of the most common malignant tumors and 20 % incidence caused by low penetrance susceptibility genes. Cyclin D1 (CCND1) regulating cell cycle transition may determine the susceptible individuals to genomic instability and carcinogenesis. The study aimed at examining the contribution of CCND1 genotypes to colorectal cancer risk in Taiwan. The genotypes of CCND1 A870G (rs9344) and G1722C (rs678653) were determined among 362 colorectal cancer patients and 362 age- and gender-matched cancer-free controls. Significant differences were observed between colorectal cancer and control groups in the distributions of genotypic (P = 9.71 × 10(-4)) and allelic (P = 0.0017) frequencies at CCND1 A870G. Additionally, individuals carried AG or GG genotype had 0.56- or 0.51-fold higher of odds ratios for developing colorectal cancer than the AA genotype (95 % confidence intervals = 0.40-0.78 and 0.32-0.81, respectively). Furthermore, G allele of CCND1 A870G performed a protective effects for nonsmokers and nonalcohol drinkers (P = 0.0012 and 0.0007, respectively) on colorectal cancer risk. These findings support the concept that the cell cycle regulation may play a role in colorectal cancer initiation and development and CCND1 A870G genotyping maybe a feasible technology for colorectal cancer early detection.

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

“…Of these, five loci were previously reported to be associated with the pathogenesis of colorectal cancer, including TNFRSF1B (rs1061624) (12), P21 (rs1059234) (13), CCND1 (rs9344) (14), NFKB1 (rs28362491) (15), and ERCC1 (rs3212986) (16) ( Table 4). …”

The Contribution of MMP-7 Genotypes to Colorectal Cancer Susceptibility in Taiwan

“…and Yang M.D. The clinical characteristics of patients, including histological details, were all graded and defined by expert surgeons (8)(9)(10)(11). All participants have completed a self-administered questionnaire and provided a 5-ml sample of peripheral blood for genotyping work.…”

“…Statistically, 15-20% of CRC cases are with strong familial cancer history that have interested the molecular epidemiologists to figure out additional genomic susceptibility factors (5)(6)(7). In Taiwan, although specific biomarkers for CRC prediction and detection have keeping on being reported in the decade (8)(9)(10)(11)(12), the interactions among the genomic and environmental risk factors, such as smoking and alcohol drinking are mostly unknown.…”

The Contribution of Excision Repair Cross-complementing Group 1 Genotypes to Colorectal Cancer Susceptibility in Taiwan

“…Jeng LB and Yang MD. The clinical characteristics of patients, including histological details, were all graded and defined by expert surgeons (9,10,13,16). All participants have completed a selfadministered questionnaire and provided a 5-ml sample of peripheral blood for genotyping work.…”

“…About 15-20% of CRC cases are with strong familial history of cancer that have interested the epidemiologists to figure out additional inherited susceptibility factors (6)(7)(8). In Taiwan, although specific biomarkers for CRC prediction and detection have keeping on being reported in recent years (9)(10)(11)(12)(13)(14)(15)(16), the genomic susceptibility of CRC and the interactions among the genomic and environmental risk factors are mostly unknown.…”