The significance of TIMD4 expression in clear cell renal cell carcinoma

Abstract

T-cell immunoglobulin and mucin domain (TIMD) family genes are related to innate immune responses. TIMD4 is a receptor for phosphatidylserine and is involved in the phagocytosis of apoptotic cells by macrophages. In the present study, we found that TIMD4 is expressed on the cancer cells of patients with clear cell renal cell carcinoma (ccRCC). TIMD4 was immunostained in the resected samples of 89 patients diagnosed as ccRCC. High expression of TIMD4 in cancer cells was closely related to short progression free survival time; however, it was not correlated with other clinicopathological factors. Intracellular expression of TIMD4 was observed in the RCC cell line, 786-O. In vitro studies using 786-O cells and shRNA targeting TIMD4 indicated that TIMD4 expression was associated with resistance to sorafenib but not with cell proliferation. TIMD4 might be useful as a prognostic factor and may also be a new target for therapy of ccRCC.

The Scavenger Receptor MARCO Expressed by Tumor-Associated Macrophages Are Highly Associated With Poor Pancreatic Cancer Prognosis

“…The AXL receptor tyrosine kinase (RTK) was implicated in the proliferation and invasion of many cancers, particularly in pancreatic ductal adenocarcinoma (PDAC) (30). Consistent with previous studies (30,31), AXL and TIMD4 increased in patients with pancreatic cancer (Figure 3C). MARCO is a pattern recognition receptor that belongs to the class A scavenger receptor family (32).…”

“…In general, AXL and TIMD4 function as two phagocytosis-related molecules in normal homeostasis (49,50). Recently, AXL and TIMD4 have also been reported to be positively correlated to the poor progression of many cancers (31,(51)(52)(53). The present study found the mRNA expression levels of AXL and TIMD4 to be increased.…”

Annexin A2 and cancer: A systematic review

“…Clear cell renal cell carcinoma (ccRCC). Annexin A2 is expressed mainly in the membrane of ccRCC and the amount of Annexin A2 in ccRCC was higher compared to normal tissue (41). In primary ccRCC tumours, the expression of Annexin A2 was positively associated with a higher TNM-stage (P<0.05) (41,42), histological grade (P<0.05) (41), infiltration of the renal capsule (P<0.01) (41) and metastatic potential (P<0.01) (41,42).…”

Use of bioinformatic database analysis and specimen verification to identify novel biomarkers predicting gastric cancer metastasis

“…Previous studies reported that NSCLC patients with high TIMD4 expression had a poor prognosis 21 . TIMD4 was overexpressed in renal cell lines, and the high expression of TIMD4 was closely related to a short progression-free survival time 22 . TIMD4 promoted the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages through the PI3K/AKT/mTOR signaling pathway 23 .…”