1986
DOI: 10.1038/icb.1986.1
|View full text |Cite
|
Sign up to set email alerts
|

The Significance of the Variety of Mechanisms of Allograft Tolerance

Abstract: Summary. The influence of variations in protocol on the induction and early stages of maintenance of allograft tolerance in neonatal rats was studied. Allogeneic bone marrow cells, the anti-recipient activity of which was specifically reduced because of their origin from immunologically tolerant donors, possessed diminished tolerogenic capacity. This was commonly manifested by development of an unreactive state in only one of the two parameters of reactivity-allograft rejection and graft-versus-host reactivity… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

1988
1988
1997
1997

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 1 publication
0
1
0
Order By: Relevance
“…Our results were not the only ones that hinted at the biological role of major transplantation antigens, and they fitted several observations made during 1972/73. In addition to the suggestions from cytotoxic T-cell studies with leukaemia, ectromelia and LCM viruses [9, 40, 41, 41a] [43,44]. In parallel experiments with inbred strains of guinea pigs, A. S. Rosenthal and E. M. Shevach analysed antigen-specific prolifera-tive T-cell responses and found them only when primed T-cells and antigen-presenting cells were from guinea pigs with the same MHC type [45].…”
Section: Interpretations Of the Datamentioning
confidence: 99%
“…Our results were not the only ones that hinted at the biological role of major transplantation antigens, and they fitted several observations made during 1972/73. In addition to the suggestions from cytotoxic T-cell studies with leukaemia, ectromelia and LCM viruses [9, 40, 41, 41a] [43,44]. In parallel experiments with inbred strains of guinea pigs, A. S. Rosenthal and E. M. Shevach analysed antigen-specific prolifera-tive T-cell responses and found them only when primed T-cells and antigen-presenting cells were from guinea pigs with the same MHC type [45].…”
Section: Interpretations Of the Datamentioning
confidence: 99%