The significance of the “tissue pressure” of normal testicular and of neoplastic (Brown‐Pearce carcinoma) tissue in the rabbit

Young, J. S.; Lumsden, C. E.; Stalker, Amy

doi:10.1002/path.1700620303

Cited by 170 publications

(81 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Young, Lumsden and Stalker (1950) demonstrated that the " tissue pressure " in Brown-Pearce carcinoma is consistently much higher than in adjacent normal tissue, and Shivas (1955) showed that this was also true in tumours grown intracerebrally, even in the presence of raised intracranial pressure. The " tissue pressure " measured by Young and his co-workers is the minimum pressure required to introduce a bland fluid into the tissue through a hollow needle.…”

Section: Discussionmentioning

confidence: 98%

“…The work of Young, Lumsden and Stalker (1950), and Shivas (1959) showing the existence of a capillary and venous hypertension in Brown-Pearce carcinoma has prompted this study of its vascularisation-in liver, to determine whether it conforms to the fairly clearly defined pattern of preferential supply from the hepatic artery. The concept of neoplastic haemodynamics confers a new importance upon the positive results obtained, and the findings of earlier workers must be re-examined.…”

Section: The Vascularisation Of Brown-pearce Carcinoma Implanted In Rmentioning

confidence: 99%

See 1 more Smart Citation

The vascularisation of Brown-Pearce carcinoma implanted in rabbit liver.

Shivas¹,

Gillespie²

1969

Br J Cancer

View full text Add to dashboard Cite

THE vasculature of tumours has been extensively studied by a variety of techniques, but interest has largely centred upon pure morphology. It is only recently that evidence has emerged for the existence of a special haemodynamic state peculiar to neoplastic growth and possibly of fundamental biological significance.The work of Young, Lumsden andStalker (1950), andShivas (1959) showing the existence of a capillary and venous hypertension in Brown-Pearce carcinoma has prompted this study of its vascularisation-in liver, to determine whether it conforms to the fairly clearly defined pattern of preferential supply from the hepatic artery. The concept of neoplastic haemodynamics confers a new importance upon the positive results obtained, and the findings of earlier workers must be re-examined.The present study utilised an injection technique with neoprene latex, which possesses good power of penetration of the microcirculation (Lieb, 1940) and produces a three-dimensional cast easily studied under the dissecting microscope. MATERIAL AND METHODSHealthy rabbits of mixed strains, aged 6-8 months, and weighing 2-3 kilogrammes, were used. Under nembutal anaesthesia, supplemented with ether as necessary, laparotomy was performed through a short upper midline incision and fresh fragments of Brown-Pearce carcinoma from a donor animal were implanted into the liver parenchyma using standard lumbar puncture needles. The operation was performed on 20 animals which were killed at intervals varying from 10 to 21 days after inoculation. Where a visible or palpable tumour was present the liver was removed after identification of the portal vein and hepatic artery, and perfused with normal saline through portex cannulae at pressures approximating to the normal in the living animal (130 mm. Hg in the hepatic artery, 15 cm. water in the portal vein). When the effluent from the hepatic vein ran consistently clear, coloured neoprene latex was injected under similar pressures. The cast was then fixed in a bath of concentrated hydrochloric acid for 48 hours, with a change of acid at 24 hours. Fat was then cleared by washing in 2-ethoxy-ethanol for 24 hours, and the casts were stored in distilled water with a crystal of thymol to prevent the growth of fungus. The importance ofusing fresh neoprene latex cannot be too strongly stressed, as prolonged storage undoubtedly diminishes the powers of penetration of the latex. RESULTSTumour growth was obtained in 8 of the 20 animals. Four livers were perfused through the portal vein, 1 through the hepatic artery and 3 through both vessels simultaneously using different colours of neoprene. The findings are summarised in Table I.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: The Vascularisation Of Brown-pearce Carcinoma Implanted In Rmentioning

confidence: 99%

The vascularisation of Brown-Pearce carcinoma implanted in rabbit liver.

Shivas¹,

Gillespie²

1969

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…This increase in tissue concentration did not affect the pharmacokinetic advantages of the IP administration. The elevated interstitial fluid pressure in tumor nodules compared to normal tissue is an acknowledged phenomenon (72,73).…”

Section: Hyperthermia Increases Membrane Permeabilitymentioning

confidence: 99%

A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement

Beeharry

Yao

et al. 2016

Transl. Gastroenterol. Hepatol.

View full text Add to dashboard Cite

Peritoneal carcinomatosis (PC) is manifested in up to 40% of gastric cancer (GC) patients, after which their 5-year survival drops to less than 5%. The currently most acceptable treatment option for advanced GC (AGC) is systemic chemo and radio therapies with however generally very unsatisfying results and this led to a resurgence of interest in regional therapies like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Small trials have indicated an association with prolonged survival when applying this technique to AGC manifesting with PC. High procedure-related morbidity and mortality associated with the CRS-HIPEC approach have however brought by a polemic on the merits of the latter: with the advent of regulatory approval of more effective as well as novel, more personalized treatment options in AGC, along with advances in tailoring investigational agents specifically for peritoneal delivery, there clearly is a need to outline the appropriate role of CRS-HIPEC in this disease.In a clear objective to improve the therapeutic efficiency of HIPEC, there have been immense developments in the technical aspects of this technology including the use of nanotechnology in more precise drug delivery systems (DDS) or choice of more efficient drugs such as gene-target technology, laparoscopy and so on. Henceforth, in this review, we will be highlighting the past and current status of the CRS + HIPEC procedure, shedding light on the pros and cons in order to boost up the efficiency of this multimodality approach.

show abstract

“…Despite the high permeability of tumour vessels, however, convective transport of macromolecules across tumour vessels may be retarded by elevated interstitial fluid pressure (IFP), a pathophysiological characteristic of animal and human tumours [86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101]. Microvascular pressure is the cause of the uniform elevation of IFP throughout tumours [88], impairing convective transport across the vessel wall.…”

Section: Cancer : From Bench To Bedside Via the Microcirculationmentioning

confidence: 99%