The significance of specific IgG and IgG4 antibodies to a reactive dye in exposed workers

Park, H. S.; Hong, Chein Soo

doi:10.1111/j.1365-2222.1991.tb01668.x

Cited by 27 publications

(10 citation statements)

References 11 publications

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“…Investigation of specific IgG and IgG 4 in workers exposed to HMW agents provided broadly similar results, since the levels of these antibodies correlated with estimates of exposure to rat allergens [100], wheat flour [101] and grain dust [102], but not with the presence of workrelated symptoms. There was an association between specific IgG and/or IgG 4 antibodies and specific IgE among workers exposed to reactive dyes [103], citrus red mite [104] and grain dust [102]. These data are consistent with those reported in asthma caused by common inhalant allergens.…”

Section: Specific Immunoglobulin G Antibodiessupporting

confidence: 91%

Pathogenesis of occupational asthma

Sastre

Vandenplas²,

Park³

2003

European Respiratory Journal

102

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The development of occupational asthma (OA) is likely to result from the complex interaction of environmental and host factors. This article addresses a series of issues relating to the multiple environmental factors that could affect the initiation of OA, including the intrinsic characteristics of causative agents, as well as the influence of the level, mode and route of exposure. Although the clinical and pathological features of OA caused by low molecular weight agents resemble those of immunoglobulin (Ig)E-mediated asthma, the failure to detect specific IgE antibodies against most of these agents and/or poor association with disease status have resulted in intense speculation about alternative or complementary physiopathological mechanisms leading to airway sensitisation. In this contribution, the roles of specific immunoglobulin E and G antibodies, cell-mediated immunity and inflammatory effector cells are critically reviewed. Recent advances in the characterisation of the molecular interactions between chemical sensitisers and human airway proteins provide promising avenues for elucidating the immunological basis of occupational asthma caused by low molecular weight agents.

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Section: Specific Immunoglobulin G Antibodiessupporting

confidence: 91%

Pathogenesis of occupational asthma

Sastre

Vandenplas²,

Park³

2003

European Respiratory Journal

102

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“…The clinical significance of sIgG response to occupational antigens seems to be complex, eliciting variable responses according to different antigens. In a study on reactive dye asthma [20], we showed that the prevalence of sIgG was significantly higher in symptomatic workers, but no association was noted according to exposure intensity or exposure duration. However, some studies in other occupational settings have suggested that the presence of sIgG may represent a response to high‐dose exposure not related to the development of respiratory symptoms [21,22].…”

Section: Discussionmentioning

confidence: 95%

Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate‐human serum albumin conjugate: useful markers for predicting long‐term prognosis in toluene diisocyanate‐induced asthma

Park

Lee

Kim

et al. 2002

Clin Experimental Allergy

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SummaryBackground Our previous study reported that more than 50% of toluene diisocyanate (TDI)-induced asthma patients had persistent asthmatic symptoms even after complete avoidance. Although specific IgE (sIgE) has been detected in a portion of patients with TDI-asthma, a recent investigation suggests that the presence of serum specific IgG (sIgG), not sIgE, is more closely associated with positive bronchoprovocation test (BPT) results. Objective To evaluate the possible role of sIgE and sIgG in predicting long-term prognosis of TDIasthma. Materials and methods Forty-one TDI-asthma patients whose diagnosis was confirmed by TDI-BPT, and 20 unexposed healthy controls were enrolled. Both sIgE and sIgG to TDI-human serum albumin (HSA) conjugate were detected by ELISA. All patients with persistent asthmatic symptoms took anti-asthmatic medications during the follow-up period (mean: 67.5 months) and were instructed to avoid exposure to TDI. Airway hyper-responsiveness to methacholine (AHM) was monitored every year during the study period. The patients were classified into three groups according to changing patterns of AHM and asthmatic symptoms as follows: group I, no improvement with persistent asthmatic symptoms (n 12); group II, partial improvement with persistent asthmatic symptoms (n 13); group III, in remission (n 16). Results Favourable prognosis was associated with a mild degree of AHM at initial diagnosis (P < 0.05). Although there were no significant differences in the prevalence of sIgE antibody to TDI-HSA conjugate among the three groups (P > 0.05), prevalence of sIgG in group I tended to be higher than in group II (0.05 < P < 0.1). However, the levels of sIgG were significantly higher in group I than in group II (P 0.05), whereas levels of sIgE were significantly higher in group II than in group I (P 0.014). No significant differences were noted in exposure duration, sex, age, atopic status, and total IgE level among the three groups (P > 0.05). Conclusion This study confirmed that a favourable outcome is related to a mild degree of AHM and to low levels of sIgG to predict persistent asthmatic symptoms, it also suggested that the presence of high serum-specific IgE at initial diagnosis may represent a better prognosis.

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“…Therefore, it has been suggested that IgG could be used to monitor the effect of exposure to diisocyanates before clinical disease appears. 103 For other occupational agents, conflicting results have been reported, showing that the prevalence of specific IgG is significantly higher in symptomatic workers, with no correlation with the level and duration of exposure, 104 or that the presence of specific IgG may be a response to high levels of exposure but is unrelated to the development of respiratory symptoms. 105,106 From the previous discussion, it is apparent that the precise role of humoral antibodies in the pathogenesis of occupational asthma depends on the intrinsic nature of the sensitizing agent or immunogen, the conditions of exposure, and the susceptibility of the exposed workers.…”

Section: Immunologic Occupational Asthma Specific Ige Antibodiesmentioning

confidence: 98%