The significance of sarcoid-like lesions in association with malignant neoplasms

Gregorie, Henry B.; Othersen, H. Biemann; Moore, McKenzie P.

doi:10.1016/0002-9610(62)90399-9

Cited by 82 publications

(34 citation statements)

References 13 publications

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“…10 Granulomatous inflammation found in lymph nodes draining carcinomas is a recognized phenomenon. [10][11][12] The background cell population needs to be scrutinized if a malignant lymphoma is suspected.…”

Section: Discussionmentioning

confidence: 99%

Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis

Gupta

Singh

2016

Int J Res Med Sci

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INTRODUCTIONFine Needle Aspiration technique was described for the first time by Greig and Gray in 1904. Since the mid-1960's, it has been increasingly used and a high degree of accuracy has been achieved.l Lymphadenopathy is one of the commonest presenting symptoms of all age groups attending out door. The etiology can vary from simple inflammatory reactive lesion to a malignant condition.Therefore lymphadenopathy requires further evaluation. FNAC has been a suitable investigation to rule out malignancies and to confirm reactive or infective pathology.2,3 The use of fine needle aspiration cytology (FNAC) in the investigation of lymphadenopathy has become an acceptable and widely practiced minimally invasive technique, which is safe, relatively painless, simple and rapid. FNAC is highly cost effective and accurate as a first line investigative technique. With the recent advances in ultrasound and CT scan technologies, focal lesions can be aspirated using this procedures. 4 Fine needle aspiration cytology (FNAC) has emerged as an advanced diagnostic tool to differentiate reactive hyperplasia/inflammatory conditions, granulomatous disorders and lymphomas. This diagnostic modality has gained considerable importance in the management of patients with lymphadenopathy over several years. We are reporting histopathological correlation of 200 cases of lymphadenopathy with FNAC. ABSTRACTBackground: Lymphadenopathy is very common presenting symptoms. Fine needle aspiration cytology (FNAC) is used to evaluate the nature of the lesion. Etiology of lymphadenopathy in head and neck region vary from benign reactive hyperplasia to tubercular granulomatous lesion to malignancy. The aim of present study was to evaluate the sensitivity, specificity and predictive value in tuberculosis and metastatic carcinoma. Methods: A total of 80 patients out of 200 patients who underwent FNAC were evaluated by histopathological examination for correlation. Aspiration smears and histopathological slides were evaluated and results were calculated for sensitivity, specificity and predictive value. Results: Reactive lymphadenitis was seen in 40 patients followed by tubercular granulomatous lymphadenitis in 20 patients and malignant lesions in 20 patients. Histology revealed 18 patients of tubercular lymphadenitis, 43 of reactive changes, 12 of metastasis in lymph nodes and 7 of lymphomas. Correlating the findings, we could achieve 100% sensitivity and 96.7% specificity for tubercular lymphadenopathy and for metastatic it was 98.5% and 100% respectively. Conclusions: We have found FNAC a satisfactory tool in the diagnosis of tubercular and malignant lymphadenopathy. FNAC used in conjunction with clinical findings, radiological and laboratory investigations can be a cost effective method for the diagnosis of lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis

Gupta

Singh

2016

Int J Res Med Sci

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“…Granülamatöz www.respircase.com reaksiyonlar uterus, meme, akciğer ve mide gibi organların malign tümörü ve lenfomalı hastalarda nadiren ortaya çıkar. Bu tür reaksiyonlar organ kanserlerinin %.4,4'ünde, Hodgkin lenfoma (HL)'nın %13,8'inde, NHL'ların %7,3'ünde görülür (4,5). Nekrotizan granülomlar lenfomada daha da nadir olarak görülür ve bu durumda yanlış tanılara yönelmeye, tanı ve tedavide gecikmelere neden olur (6).…”

Section: Discussionunclassified

INTERACTIVE CASE REPORT: Lymphoma Case Mimicking Tuberculosis

Bulcun¹,

Ekici²,

Ekici³

et al. 2016

Respir Case Rep

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“…[15][16][17] Epithelioid cell and sarcoid-like granulomas have been observed in regional lymph nodes and tumor stroma in a few cases of breast cancer and the incidence is 0.7% for regional lymph nodes and 0.3% for tissue stroma. 18,19 In the case under discussion, if the clinical staging would have been T2N0M0 preoperatively, the patient would have been offered the BCS considering her younger age and suitability with other parameters for BCS; however, the clinical over staging led to the loss of opportunity for such an offer.…”

Section: Discussionmentioning

confidence: 99%

Synchronous breast cancer and ipsilateral primary tuberculous lymphadenitis in axillary node

et al. 2015

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Tuberculous lymphadenitis is the commonest form of extrapulmonary tuberculosis with special affinity for cervical, mediastinal, and axillary lymph-nodes. Whilst both carcinoma of the breast and tuberculosis are common in countries with limited resources, the synchronous presence of breast cancer and ipsilateral tuberculous lymphadenitis, can lead to the overstaging of nodes leading to loss of opportunity for breast conservation. We present a case report in which a young woman presented with breast lump along with axillary nodes. However, after surgical resection, it was found that axillary nodal involvement was solely by tuberculosis. Keywords: Tuberculous lymphadenitis, Carcinoma breast, Overstaging, Axillary node

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The significance of sarcoid-like lesions in association with malignant neoplasms

Cited by 82 publications

References 13 publications

Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis

Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis

INTERACTIVE CASE REPORT: Lymphoma Case Mimicking Tuberculosis

Synchronous breast cancer and ipsilateral primary tuberculous lymphadenitis in axillary node

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