The significance of regional hemoglobin oxygen saturation values and limb-to-arm ratios of near-infrared spectroscopy to detect critical limb ischemia

Boezeman, Reinout P.E.; Boersma, Doeke; Wille, Jan; Kelder, Johannes C.; Visscher, Mareije I; Waanders, Frans G.; Moll, Frans L.; Vries, Jean-Paul Pm de

doi:10.1177/1708538115613936

Cited by 8 publications

(5 citation statements)

References 25 publications

(21 reference statements)

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“…To our knowledge, we are the first group to investigate the effects of prolonged sitting and prolonged sitting in a mild hypercapnic environment on microvascular oxygenation measurements in skeletal muscle in the lower extremities. Microvascular oxygenation and O 2 use were assessed using NIRS, which is a noninvasive method of determining tissue [HbO 2 ], [HHb], and [Hbtot] as well as TOI (7). TOI represents the balance between O 2 delivery and utilization, which is affected by the balance between blood flow to the tissue and tissue metabolic activity (25).…”

Section: Discussionmentioning

confidence: 99%

Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults

Headid

Pekas

Wooden

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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Prolonged sitting, which is known to impair peripheral vascular function often occurs in spaces (e.g. offices) with mild hypercapnic atmospheres. However, the effects of prolonged sitting in hypercapnic conditions on vascular function are unknown. Therefore, the purpose of this study was to investigate the effects of prolonged sitting in mild hypercapnic conditions on vascular and autonomic function in humans. Methods: 12 healthy young adults participated in two experimental visits which consisted of sitting for 2.5 hours in a control condition (PSIT) or a mild hypercapnic condition (HCAP, CO2=1,500 ppm). During each visit, heart rate variability (HRV), blood pressure (BP), pulse wave velocity (PWV), augmentation index (AIx), brachial and popliteal artery flow mediated dilation (FMD), and near infrared spectroscopy (NIRS) were assessed before and after prolonged sitting. Results: Sitting significantly decreased AIx in both groups (P<0.05). Brachial and popliteal FMD were reduced with sitting (P<0.05), and the reduction in popliteal FMD was amplified by HCAP (P<0.05). Baseline microvascular oxygenation was decreased following sitting in both groups (P<0.05). However, microvascular reoxygenation upon cuff release was slower only in HCAP (P<0.05). HRV, HR, BP, and PWV did not significantly change with sitting in either group (P>0.05). Conclusion: Prolonged sitting attenuated both brachial and popliteal endothelial function and was associated with perturbed microcirculation. Additionally, mild hypercapnic conditions further impaired peripheral endothelial and microvascular function. Together, these findings suggest that prolonged sitting is accompanied by a host of deleterious effects on the vasculature, which are exacerbated by mild hypercapnia.

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Section: Discussionmentioning

confidence: 99%

Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults

Headid

Pekas

Wooden

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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“…One of the limitations of NIRS is the measurement of locations with more adipose tissue, which can cause inaccurate values [27]. NIRS is also limited by tissue infection and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Boezeman et al [27] studied 61 patients with PAD and 30 healthy controls. Assessment of PAD was performed by diagnostic imaging, and afterward, patients were categorized in Fontaine classification 3 or 4.…”

Section: Application Within Padmentioning

confidence: 99%

A systematic review of diagnostic techniques to determine tissue perfusion in patients with peripheral arterial disease

Kirsten

Kleiss

Schuurmann

et al. 2019

Expert Review of Medical Devices

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“…Limitations of NIRS include overlying infection/inflammation and the strong possibility of erroneous measurements when examining tissues with an abundance of overlaying fat[ 97 ]. Moreover, NIRS measurement results can be sensitive to oxygen delivery and extraction[ 98 ].…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

Quantifying tissue perfusion after peripheral endovascular procedures: Novel tissue perfusion endpoints to improve outcomes

Arkoudis¹,

Κατσάνος²,

Inchingolo³

et al. 2021

WJC

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Peripheral artery disease (PAD) is a flow-limiting condition caused by narrowing of the peripheral arteries typically due to atherosclerosis. It affects almost 200 million people globally with patients either being asymptomatic or presenting with claudication or critical or acute limb ischemia. PAD-affected patients display increased mortality rates, rendering their management critical. Endovascular interventions have proven crucial in PAD treatment and decreasing mortality and have significantly increased over the past years. However, for the functional assessment of the outcomes of revascularization procedures for the treatment of PAD, the same tests that have been used over the past decades are still being employed. Those only allow an indirect evaluation, while an objective quantification of limb perfusion is not feasible. Standard intraarterial angiography only demonstrates post-intervention vessel patency, hence is unable to accurately estimate actual limb perfusion and is incapable of quantifying treatment outcome. Therefore, there is a significant necessity for real-time objectively measurable procedural outcomes of limb perfusion that will allow vascular experts to intraoperatively quantify and assess outcomes, thus optimizing treatment, obviating misinterpretation, and providing significantly improved clinical results. The purpose of this review is to familiarize readers with the currently available perfusion-assessment methods and to evaluate possible prospects.

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The significance of regional hemoglobin oxygen saturation values and limb-to-arm ratios of near-infrared spectroscopy to detect critical limb ischemia

Cited by 8 publications

References 25 publications

Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults

Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults

A systematic review of diagnostic techniques to determine tissue perfusion in patients with peripheral arterial disease

Quantifying tissue perfusion after peripheral endovascular procedures: Novel tissue perfusion endpoints to improve outcomes

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