The significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel

Hindsén, Monica; Bruze, M.; Christensen, Ole

doi:10.1111/j.1600-0536.1997.tb00312.x

Cited by 57 publications

(59 citation statements)

References 12 publications

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“…When the number of negative and/or doubtful reactions was followed by at least the same number of positive reactions, the lowest positive reaction was considered the MEC (12). If negative or doubtful reactions at 2.0% and 1.3% were followed by a positive reaction at 1.0% (as in subject 3), the latter was registered as the MEC.…”

Section: Statisticsmentioning

confidence: 99%

Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol

Mowitz¹,

Svedman²,

Zimerson³

et al. 2014

Acta Derm Venerol

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Atranol and chloroatranol are strong contact allergens in oak moss absolute, a lichen extract used in perfumery. Fifteen subjects with contact allergy to oak moss absolute underwent a repeated open application test (ROAT) using solutions of an untreated oak moss absolute (sample A) and an oak moss absolute with reduced content of atranol and chloroatranol (sample B). All subjects were in addition patch-tested with serial dilutions of samples A and B. Statistically significantly more subjects reacted to sample A than to sample B in the patch tests. No corresponding difference was observed in the ROAT, though there was a significant difference in the time required to elicit a positive reaction. Still, the ROAT indicates that the use of a cosmetic product containing oak moss absolute with reduced levels of atranol and chloroatranol is capable of eliciting an allergic reaction in previously sensitised individuals.

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Section: Statisticsmentioning

confidence: 99%

Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol

Mowitz¹,

Svedman²,

Zimerson³

et al. 2014

Acta Derm Venerol

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“…We found signi¢cantly higher test reactivity in areas where there had been nickel contact dermatitis previously, compared with areas where there had never been nickel eczema before. We also found that the shorter the time interval between previous eczema and topical re-exposure, the stronger the reaction (1). Whether this increased re-test reactivity is allergen-speci¢c or also exists after allergic contact dermatitis from other sensitizers is unclear.…”

mentioning

confidence: 73%

“…With regard to SLS, the test occlusion time used was 24 h, the time most frequently used in studies of irritant skin reactions (8). The same test system was used as in a previous study (1) to produce an experimental eczema as homogeneous as possible. In order to provoke the same degree of epidermal in£ammation from the experimentally induced allergic and irritant contact dermatitis, the patients were patch tested with a serial dilution of nickel sulfate, cobalt chloride, and SLS immediately before the provocation.…”

Section: On the Designmentioning

confidence: 99%

The Significance of Previous Contact Dermatitis for Elicitation of Contact Allergy to Nickel

Hindsén

Bruze²

1998

Acta Dermato-Venereologica

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In 2 earlier studies, we found increased nickel re-test reactivity at earlier experimentally induced nickel eczema sites. The aim of this study was to investigate if earlier contact dermatitis caused by another allergen or earlier irritant contact dermatitis also influenced the reactivity when nickel was applied topically on earlier but healed dermatitis sites. Twenty-three females with contact allergy to both nickel and cobalt were involved in the study. Experimental contact dermatitis from nickel, cobalt and SLS was induced on the lower back. One month later, challenge patch testing with a serial dilution of nickel on the previous but healed dermatitis sites, and on a control area, was done. The tests were read blindly. Significantly higher test reactivity was found at the site with previous allergic contact dermatitis from nickel, and significantly lower test reactivity was observed at the previous SLS dermatitis site.

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“…For example, there was no effect on the nickel reactivity when SLS was administered simultaneously with the allergen by an open application procedure on normal forearm skin (Menne´and Calvin 1993). However, the nickel reactivity was decreased when contact dermatitis was provoked by SLS 1 month prior to a nickel closedchallenge patch test on the compromised skin area on the back (Hindse´n et al 1997). In contrast, the nickel reactivity was increased on forearm skin if SLS dermatitis was provoked by immersion in SLS solution a few hours prior to the nickel challenge (Allenby and Basketter 1993).…”

Section: Dose-response Relationshipmentioning

confidence: 92%

Occupational issues of allergic contact dermatitis

Andersen

2003

International Archives of Occupational and Environmental Health

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Occupational contact dermatitis is often of multifactorial origin, and it is difficult to determine the relative significance of the various contributing factors. Contact allergies are relevant in 20-50% of recognised occupational contact dermatitis cases. The reported frequency in different studies varies, depending on differences in how occupational diseases are notified and recognised, in types of occupation in a geographical area, and the "quality" of the dermatological examination, including the accuracy of the diagnostic patch-test investigation. However, the clinical relevance of the reported contact allergies is often uncertain. Many occupational contact dermatitis patients with documented contact allergies develop chronic eczema, in spite of work changes and attempted allergen avoidance. Recognition/non-recognition of a notified case may be based on circumstantial evidence, because of difficulties in the establishing of a firm proof of work exposure and subsequent development of skin disease. Reliable quantitative exposure measuring techniques are needed. Methods are developed for the measurement of exposure to allergens such as nickel and acrylates, which makes it possible for exposure-effect relationships to be established with increased certainty. For prevention of allergic contact dermatitis it was a major step forward, with mandatory ingredient labelling of cosmetic products. However, improved labelling of the presence of contact allergens in household and industrial products is needed. For the identification of hazardous contact allergenic compounds, guinea pig or mice assays are still required. The local lymph node assay (LLNA), which is an objective and sensitive mouse assay has now been internationally validated and accepted.

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The significance of previous allergic contact dermatitis for elicitation of delayed hypersensitivity to nickel

Cited by 57 publications

References 12 publications

Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol

Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol

The Significance of Previous Contact Dermatitis for Elicitation of Contact Allergy to Nickel

Occupational issues of allergic contact dermatitis

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