The Significance of Placental Infarction in Perinatal Morbidity and Mortality

Fox, H.

doi:10.1159/000240056

Cited by 54 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is not true in general that FTF deposition occurs less frequently in abnormal pregnancies (Aherne and Dunnill, 1966;Fox, 1967bFox, , 1975Teasdale, 1984Teasdale, , 1985Teasdale, , 1987Mayhew et al, 1994;Kaufmann et al, 1996;Mayhew and Sisley, 1998;Mayhew et al, 2000). The present finding confirms that FTF volume is less in high-altitude pregnancies despite the presence of a more voluminous IVS and an increase in the mean volume of its 'pores' (Jackson et al, 1987a;Lee and Mayhew, 1995).…”

Section: Low Altitudesupporting

confidence: 66%

“…Typically, FTF occupies a relatively small volume (2-5%) of the IVS at term and this amounts to roughly 5-10 cm 3 (Laga et al, 1973;Jackson et al, 1987a). Fox (1967bFox ( , 1975 proposed that the amount of FTF merely reflects the quality of IVS perfusion. If we take IVS volume as a measure of perfusion, the present findings support this proposal as well as the observations of others which indicate that volumes of IVS and FTF increase throughout gestation (Aherne and Dunnill, 1966;Boyd, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…It has been argued (Fox, 1967b(Fox, , 1975 that, normally, the amount of FTF simply reflects the quality of vascular perfusion within the IVS and, in abnormal pregnancies, deposition is diminished. Morphometric studies on placentas collected at different stages of gestation have indicated that volumes of 'fibrin' and IVS both increase towards term (Aherne and Dunnill, 1966;Boyd, 1984).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fibrin-Type Fibrinoid in Human Placenta: A Stereological Analysis of Its Association With Intervillous Volume and Villous Surface Area

Mayhew¹

2011

Image Anal Stereol

View full text Add to dashboard Cite

Stereological methods were used to examine fibrin-type fibrinoid deposition in the intervillous spaces of human placentas collected during gestation (12-41 weeks) and from term pregnancies at low (400 m) and high (3.6 km) altitude. The main aim was to test predictions about the relationships between fibrinoid deposits and either the volume of intervillous space or the surface area of (intermediate + terminal) villi. Fields of view on Masson trichrome-stained paraffin sections were selected as part of a systematic sampling design which randomised section location and orientation. Relative and absolute volumes were estimated by test point counting and surfaces by intersection counting. Apparent differences were tested by analyses of variance and relationships by correlation and regression analysis. Fibrinoid volume increased during gestation and correlated positively with intervillous volume and villous surface area. However, relative to intervillous volume, the main increase in fibrinoid occurred towards term (36-41 weeks). At high altitude, placentas contained more intervillous space but less fibrinoid. At both altitudes, there were significant correlations between fibrinoid volume and villous surface area. In all cases, changes in fibrinoid volume were commensurate with changes in villous surface area. Whilst findings lend support to the notion that fibrinoid deposition during normal gestation is influenced by the quality of vascular perfusion, they also emphasise that the extent of the villous surface is a more generally important factor. The villous surface may influence the steady state between coagulation and fibrinolysis since some pro-coagulatory events operate at the trophoblastic epithelium. They occur notably at sites of trophoblast de-epithelialisation and these arise following trauma or during the extrusion phase of normal epithelial turnover.

show abstract

Section: Low Altitudesupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fibrin-Type Fibrinoid in Human Placenta: A Stereological Analysis of Its Association With Intervillous Volume and Villous Surface Area

Mayhew¹

2011

Image Anal Stereol

View full text Add to dashboard Cite

show abstract

“…3 According to Fox, in uncomplicated pregnancy placental infarction play little role in perinatal mortality and morbidity. 4,5 But extensive infarction as found in hypertensive in hypertensive complication of pregnancy is associated with high incidence of fetal hypoxia. This correlated with the present study where there was 18 out of 28 cases (64.28%) showed APGAR Score <7 in the study group, where Grade-III changes are seen before 34 weeks.…”

Section: Discussionmentioning

confidence: 99%

The ultrasonic changes in maturing placenta in pregnancy complicated with hypertension and its correlation with neonatal outcome

Dutta

Chatterjee

Sen

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. Obstetric ultrasound provides a cornerstone to other modalities used for assessing hypertensive disorders of pregnancy. This study was designed to detect the placental changes in hypertensive disorders of pregnancy and correlation with neonatal outcome.Methods: The study group comprised of 42 patients with pregnancy complicated with hypertension with period of gestation above 20 weeks and B.P. more than 140/90 mm of Hg measured on two occasions 6 hours or more apart. The control group consists of 42 normotensive patients matched with age and parity. One ultrasonic examination were performed between 28 weeks and 34 weeks and another after 34 weeks till term. Apart from routine parameters i.e. BPD, AC, FL, Amniotic fluid index, EBW and gestational age routine placental grading were performed according to the classification proposed by Grannum and associates. To evaluate perinatal outcome following measurement were studied – birth weight immediately after delivery, mode of delivery, perinatal morbidity and mortality , APGAR score , presence of fetal distress.Results: In 97.62% cases (41 out of 42 ) of control group showed Grade–II changes as opposed to 57.14% of cases (24 out of 42) in study group before 34 weeks.Conclusions: Accelerated maturation of placenta in pregnancy complicated with hypertension are more common in the hypertensive group.

show abstract

“…Calcification of placenta is a sign of physiological maturity of placenta [26] . More mature and heavy the placenta more is the extent of calcified patches [27] . Placental calcification occurs earlier in pregnancy in cigarette smokers [28] .…”

Section: Maternal Surface Rough Irregular Consists Of 15-30mentioning

confidence: 99%

Morphological Changes of Placenta Associated with Maternal Anaemia

Mondal¹,

Baske²,

Biswas³

2017

IJLSSR

View full text Add to dashboard Cite

ABSTRACT-Placenta is the mirror of fetomaternal status. The effect of anemia in pregnancy can be diverse and detrimental to the mother and the fetus. This prompted us to carry out the present study, which aimed to observe and compare the morphological features of placenta at term in anemic and non-anemic mothers of North Bengal and to find out the clinical relevance of such structural changes. Total 30 placentas were collected from each group of selected patients after delivery at labor room. Examination of placenta was conducted according to proforma. A general survey of umbilical cord, membranes, fetal surface, and maternal surface was carried out. The diameters were measured, area was estimated, and shape was noted. Placenta and fetus was weighed in the same scale. The volume was estimated by water displacement method. In anemic mothers, mean baby birth weight was found to be significantly less than that of control group. The mean placental weight in test group was significantly increased in comparison to controls. The mean placental volume and mean placental area in case of test group were significantly increased. Occurrence of morphological features, like subchorionic fibrosis; retroplacental clot, gross calcification, or placental infarction etc were found to be significantly higher in anemic mothers in comparison to non-anemic group. In the present study, it was proved that placenta has considerable functional reserve capacity. It tends to limit the ill-effects of tissue injury and of unfavorable maternal milieu like anemia. Our findings were in accordance with the previous studies in this field.

show abstract

The Significance of Placental Infarction in Perinatal Morbidity and Mortality

Cited by 54 publications

References 34 publications

Fibrin-Type Fibrinoid in Human Placenta: A Stereological Analysis of Its Association With Intervillous Volume and Villous Surface Area

Fibrin-Type Fibrinoid in Human Placenta: A Stereological Analysis of Its Association With Intervillous Volume and Villous Surface Area

The ultrasonic changes in maturing placenta in pregnancy complicated with hypertension and its correlation with neonatal outcome

Morphological Changes of Placenta Associated with Maternal Anaemia

Contact Info

Product

Resources

About