The Significance of Ph<sup>1</sup> Mosaicism: a Report of Six Cases of Chronic Granulocytic Leukaemia and Two Cases of Acute Myeloid Leukaemia

Wayne, A. W.; Sharp, J. C.; Joyner, Miles V.; Sterndale, H.; Pulford, Karen

doi:10.1111/j.1365-2141.1979.tb03762.x

Cited by 14 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has not been found outside the lymphoproliferative disorders. l h e main conclu- FRANCESCONI and PASQUALI 1978;MITELMAN et al 1978;WAYNE et al 1979;GARSON 1980;F. CARBONELL pers.…”

Section: The Specificity Of Marker Chromosomesmentioning

confidence: 99%

Clustering of aberrations to specific chromosomes in human neoplasms

2009

View full text Add to dashboard Cite

This survey of chromosomal aberrations in human neoplasms comprises 1,871 cases distributed on 15 groups of malignant disease, viz. 4 groups of myeloproliferative disorders with 1,328 cases, 5 groups of lymphoproliferative disorders with 369 cases and 6 groups of solid tumors with 174 cases. The material is presented in 17 tables, in which the variation of each chromosome is listed separately for each geographic region. In the discussion part a number of special problems are looked into. The difference in variation between the individual chromosomes was highly signifcant statistically. Within each tumor, all chromosomes which exceeded the average variation with more than 1 standard deviation were considered selectively involved. In all neoplasms taken together, the chromosomes selectively involved clustered to 15 of the 24 human chromosome types. Other topics taken up for discussion were the following: possible differences in chromosome variation between geographic regions; the specificity of certain marker chromosomes; the hypothesis of 2 essentially different kinds of chromosome aberration in cancer. The phenomena of genic amplification and recurrent translocation often found in cancer require the assumption of unorthodox cytogenetic mechanisms. One main conclusion of the paper is that the aberrations of the selectively involved chromosomes influence cancer development because of the genes they carry.

show abstract

“…It has not been found outside the lymphoproliferative disorders. l h e main conclu- FRANCESCONI and PASQUALI 1978;MITELMAN et al 1978;WAYNE et al 1979;GARSON 1980;F. CARBONELL pers.…”

Section: The Specificity Of Marker Chromosomesmentioning

confidence: 99%

Clustering of aberrations to specific chromosomes in human neoplasms

2009

View full text Add to dashboard Cite

show abstract

Chronic myelogenous leukemia: Prolonged survival with spontaneous decline in the frequency of Ph1-positive cells and subsequent development of mixed Ph1-positive and Ph1-negative blast crisis

Appelbaum

Najfeld

Singer

1983

Cancer

View full text Add to dashboard Cite

A 23‐year‐old man developed Ph1‐positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph1‐positive me‐taphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without further therapy. During that time there was a progressive decline in the frequency of Ph1‐positive metaphases in his bone marrow to 3% by 1976. His disease subsequently transformed to an acute lymphoblastic leukemia. Cytogenetic studies of the marrow at the onset of blast crisis and of cultured marrow blast cells suggested that the blasts were a mixture of Ph1‐positive and Ph1‐negative cells. This patient was thus unique in that he demonstrated spontaneous decline in the frequency of Ph1‐positive cells in his bone marrow and he developed blast crisis with an apparent mixture of Ph1‐positive and Ph1‐negative blasts. These findings demonstrate that a Ph1‐positive cell clone may lose its proliferative advantage over Ph1‐negative cells and raise the possibility that Ph1‐negative cells persisting in patients with Ph1‐positive chronic myelogenous leukemia may be abnormal and, like the Ph1‐positive cells, may be susceptible to acute leukemic transformation.

show abstract

Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia

Smadja¹,

Krulik²,

Gramont³

et al. 1985

Cancer

View full text Add to dashboard Cite

The authors present a case of Philadelphia (Ph1) positive acute myeloblastic leukemia (AML) following a refractory anemia with excess of blasts (RAEB) that had been Ph1‐negative for 17 months. During the transformation of RAEB into AML, the Ph1 was discovered in 100% of the examined cells. With therapy a partial remission was obtained, during which some 46,XY cells reappeared mixed with Ph1 cells along with a new clone: 47,XY,+11 originating from a Ph1‐negative cell. During the terminal blast crisis, the karyotype returned to 46,XY,Ph1. The AML lasted 21 months. The authors discuss: (1) the significance of Ph1‐positive AML with a review of the literature; (2) the de novo acquisition of a Ph1 during the course of a blood disorder; and (3) the meaning of a second abnormal clone originating from 46,XY cells.

show abstract

The Significance of Ph¹ Mosaicism: a Report of Six Cases of Chronic Granulocytic Leukaemia and Two Cases of Acute Myeloid Leukaemia

Cited by 14 publications

References 32 publications

Clustering of aberrations to specific chromosomes in human neoplasms

Clustering of aberrations to specific chromosomes in human neoplasms

Chronic myelogenous leukemia: Prolonged survival with spontaneous decline in the frequency of Ph1-positive cells and subsequent development of mixed Ph1-positive and Ph1-negative blast crisis

Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia

Contact Info

Product

Resources

About

The Significance of Ph1 Mosaicism: a Report of Six Cases of Chronic Granulocytic Leukaemia and Two Cases of Acute Myeloid Leukaemia

Cited by 14 publications

References 32 publications

Clustering of aberrations to specific chromosomes in human neoplasms

Clustering of aberrations to specific chromosomes in human neoplasms

Chronic myelogenous leukemia: Prolonged survival with spontaneous decline in the frequency of Ph1-positive cells and subsequent development of mixed Ph1-positive and Ph1-negative blast crisis

Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia

Contact Info

Product

Resources

About

The Significance of Ph¹ Mosaicism: a Report of Six Cases of Chronic Granulocytic Leukaemia and Two Cases of Acute Myeloid Leukaemia