The significance of nanoparticles in brain cancer diagnosis and treatment: modeling and simulation

Abstract

A numerical analysis of specific absorption rate (SAR) and temperature distributions in a realistic human head model is presented in this study. The key challenge is to rise cancer temperature to an optimal temperature without heating nearby healthy tissues. The model's uniqueness is that it captures the effect of nanoparticles on both brain cancer diagnosis and treatment. A realistic human head model with a cancerous brain segmented from 2D magnetic resonance imaging (MRI) gained from an actual patient using 3D Slicer, modeled, and simulated using CST-Microwave Studio, and illuminated by Archimedes spiral antenna. At frequencies of 2450 MHz and 915 MHz, the model simulated the absence and presence of various nanoparticles. The obtained results suggest that when using nanoparticles, it is possible to achieve sufficient energy deposition and temperature rise to therapeutic values (greater than 42o C) in brain cancers using the proposed noninvasive hyperthermia system at 915 MHz frequency, especially for gold nanoparticles, without harming surrounding healthy tissue. Our research might pave the way for a clinical applicator prototype that can heat brain cancer.

Chemotherapeutic Potential of AgNP Orchestrated Semecarpus anacardium Nut Extracts Against Ovarian Cancer Cell Line, PA-1

“…The difficulties posed by using harmful chemical reagents may be resolved by the synthesis of AgNPs using phyto molecules. Other than silver, several metal nanoparticles have been used for synthesizing nanoparticles which are used in different cancers to prove their efficacy in chemotherapeutics as well as immunotherapy [51][52][53][54][55][56][57][58][59][60][61][65][66][67][68][69][70]. Apart from metal nanoparticles, synthesis of photonic nanoparticles has also been tremendously increased in the recent years for cancer therapeutics [62].…”