The significance of nanofiber polyglycolic acid for promoting tissue repair in a rat subcutaneous implantation model

Abstract

Among various biomaterials, we focused on nanofiber-based polyglycolic acid (PGA) fabric and examined the dynamics of cells that migrate within the non-woven fabric after implantation. The efficacy of nano-PGA as a tissue reinforcement in the process of subcutaneous tissue repair was immunohistochemically investigated. Two types of

Physical pressure resistance of gastrointestinal anastomotic site via polyglycolic acid promoting fibrosis

“…PGA sheets can play an important role as scaffolds, inducing the in ltration of in ammatory cells in the early postoperative period. This results in the recruitment of broblasts, which form a physical barrier of brosis and ultimately serve as a scaffold to promote the formation of granulation tissue, which is required to promote tissue regeneration [12,13] We previously reported the usefulness of double-stapling technique anastomosis combined with PGA sheets for rectal cancer surgery. Although a small number of cases were evaluated in this report, we observed that the incidence of anastomotic leakage in the PGA sheet group was signi cantly lower even after propensity score matching [10].…”

Development of new bioabsorbable implants with de novo adipogenesis

“…In this study, we first used PGA nanosheets as a substitute for the internal filling material for CS in adipose regeneration research. PGA nanosheets are synthetic materials that can be inexpensively manufactured in large quantities without the risk of viruses and other hazards caused by biomaterials [ [32] , [33] , [34] ]. The regeneration of adipose tissue in the PLLA with PGA nano group was equal to that in PLLA groups using CS at both 6 and 12 months.…”

“…5 ). It's reported that PGA contains extra-fine fibers with a large surface area and which results in high cellular characteristics [ 33 ]. Therefore, PGA nanosheets are an alternative internal filling material in the de novo adipogenesis.…”

Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications

“…Nano-PGA sheets demonstrated enhanced tissue compatibility compared to regular PGA by triggering early polarization to the M2 phenotype, leading to angiogenesis and tissue repair. 110 Veleirinho et al developed PET-based electrospun non-absorbable mats for the correction of abdominal malformations in the absence of intestinal adhesion. The electrospun meshes were flexible and had excellent suture retention.…”