The Significance of Low Magnesium Levels in COVID-19 Patients

Coman, Adorata Elena; Ceasovschih, Alexandr; Petroaie, Antoneta Dacia; Popa, Elena; Lionte, Cătălina; Bologa, Cristina; Haliga, Raluca Ecaterina; Cosmescu, Adriana; Slanina, Ana Maria; Bacusca, Agnes; Șorodoc, Victorița; Şorodoc, Laurenţiu

doi:10.3390/medicina59020279

Cited by 14 publications

(18 citation statements)

References 147 publications

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“…While our study did not find significant changes in hematological factors such as hs-CRP and TNF-α levels, it is important to acknowledge the multifactorial nature of COVID-19 pathogenesis [ 50 ]. The observed clinical improvements may be mediated through alternative pathways, such as magnesium’s neuroprotective properties and its role in neurotransmitter regulation [ 51 ]. The reduction in depression scores observed in the magnesium group underscores the potential neuropsychiatric benefits of magnesium supplementation, which may be independent of its effects on inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

Rostami,

Alavi,

Daghagheleh

et al. 2024

Virol J

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Background This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19. Methods This double-blind, randomized clinical trial was conducted at Razi Hospital, Ahvaz, Iran, between September 2021 and March 2022. Participants aged 18–70 years with moderate disease severity were enrolled. Magnesium supplementation (300 mg daily) was administered to the intervention group, while the control group received a placebo. Clinical outcomes, including the need for oxygen therapy, oxygen saturation, respiratory rate, fever, hs-CRP and TNF-α levels, as well as quality of life and mental health, were assessed. Blood samples were collected to measure biochemical variables. Results The main result was the count of individuals requiring oxygen therapy. Additional outcomes comprised of oxygen saturation, respiratory rate, fever, hs-CRP and TNF-α levels, as well as quality of life and mental health. Out of 64 participants, 60 completed the study. The results showed that magnesium supplementation significantly reduced the number of patients requiring oxygen therapy (9 vs. 14; P < 0.001). Moreover, the magnesium group demonstrated improved oxygen saturation compared to the control group (4.55 ± 2.35 vs. 1.8 ± 1.67; P < 0.001). Furthermore, we observed a noteworthy enhancement in the quality of life and depression score in the magnesium group. No significant differences were observed in respiratory rate, fever, hs-CRP, and TNF-α levels (P > 0.05). Conclusion The findings suggest that magnesium supplementation may have beneficial effects on clinical outcomes and arterial oxygen saturation in COVID-19 patients. More investigation is necessary to delve into its potential mechanisms and long-term effects on patient outcomes. Trial registration This study is registered on Iranian Registry of Clinical Trials (IRCT) under identifier IRCT20210413050957N1. (The registration date: May 1, 2021).

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Section: Discussionmentioning

confidence: 99%

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

Rostami,

Alavi,

Daghagheleh

et al. 2024

Virol J

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“…The trend that was identified in the present study, should be further validated on large cohorts in a multicentric clinical study. Thus, the results are consistent, but some other covariates could influence the QoL, including medication adherence or fatigue, assessed by evaluating post-stroke QoL (37). In order to quantify the HRQoL, a valid tool for the Romanian population is required, based on a precise and valid measurement algorithm for stroke patients.…”

Section: Location Of the Stroke Difference In Scores For ------------...mentioning

confidence: 91%

“…The aim of the present study was to identify the multidimensional effects of post-stroke HRQoL among patients and caregivers, in order to propose and implement suitable intervention approaches, to support the transition from hospital to home after stroke, in Romania (36)(37)(38).…”

Section: Location Of the Stroke Difference In Scores For ------------...mentioning

confidence: 99%

Quality of life three months post‑stroke among stroke patients and their caregivers in a single center study from Romania during the COVID‑19 pandemic: A prospective study

et al. 2023

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The aim of the present study was to determine the health-related quality of life of stroke patients and their caregivers during the fifth wave of the COVID-19 pandemic. A total of 70 patients who had been diagnosed with stroke between October 2021 and March 2022 and 70 caregivers were included in the present study. A prospective follow-up study assessing the quality of life at baseline was conducted after 3 months for both patients and their caregivers. A linear regression analysis was performed to evaluate potential associations between quality of life and assessed factors. The results revealed that age, sex, employment status, hospitalization period, type of stroke, Barthel index for activities of daily living (ADL) and discharge Modified Rankin Scale (mRS), were significant determinants of the 90-day Health-Related Quality of Life (HRQoL). An important clinical change in the QoL score was estimated for both post-stroke patients and their caregivers. The decrease of the HRQoL of patients was statistically influenced by a higher value of ADL (P=0.014), whereas, in the case of their caregivers, the decrease of HRQoL was primarily influenced by the QoL of patients after 3 months (P= 0.043). The present study identified some important key factors with direct consequences on HRQoL regarding stroke survivors and their caregivers.

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“…Symptoms such as chronic fatigue, dif5iculty in concentration and attention, impaired memory, excessive nervousness and irritability, and hair loss may also occur. A consequence of immune system dysfunction are frequent infections, mainly of the respiratory system, of varying aetiologies [7].…”

Section: Newborns and Infantsmentioning

confidence: 99%

Zinc and Magnesium vs COVID - 19

Sokołowska¹,

Nazaruk²,

Radzka-Pogoda

et al. 2022

Polish Hyperbaric Research

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Zinc and magnesium are among the most important elements for the human body. A deficiency or excess of either of them may pose a potential threat to the homeostatic mechanisms of the body. Both elements condition the proper functioning of the immune system. Zinc and magnesium deficiency significantly reduces the body's immunity, facilitating infection with various pathogens, including SARS-COV-2 infection. In this paper, we reviewed the literature on the impact of zinc and magnesium deficiencies on the incidence and course of COVID-19.

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The Significance of Low Magnesium Levels in COVID-19 Patients

Cited by 14 publications

References 147 publications

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

Quality of life three months post‑stroke among stroke patients and their caregivers in a single center study from Romania during the COVID‑19 pandemic: A prospective study

Zinc and Magnesium vs COVID - 19

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