The Significance of Laryngopharyngeal Reflux in Benign Vocal Mucosal Lesions

Chung, Jae Ho; Tae, Kyung; Lee, Yong Seop; Jeong, Jin Hyeok; Cho, Seok Hyun; Kim, Kyung Rae; Park, Chul Won; Han, Dong Soo

doi:10.1016/j.otohns.2009.05.033

Cited by 73 publications

(69 citation statements)

References 17 publications

(34 reference statements)

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“…(P \ 0.001). Furthermore, 52.8% of patients with TVFLs had abnormal distal esophageal acid contact, which confirms observations from previous studies associating TVFLs with LPR [8][9][10]. In the control group of typical GERD, 4 (16.7%) patients had one LPRE each and were considered LPR?, a finding in accordance with the study by Byrne et al [22] who used a similar pH monitoring catheter but a different analysis methodology to find pathologic LPR at a threshold of 3 LPREs at pH \ 4 in 21% of 276 GERD patients.…”

Section: Discussionsupporting

confidence: 85%

“…Kuhn et al [8] recorded pharyngeal reflux episodes on 24-h double probe, pH monitoring in 7 out of 11 patients with VFNs, while Ulualp et al [9] recorded pharyngeal reflux episodes in 7 of 9 patients with posterior laryngitis and VFNs. In a large study conducted in South Korea, Chung et al [10] documented LPR in 33 of 50 patients with VFNs, in 30 of 40 patients with VFPs and in 16 of 18 patients with RE. With respect to VFPs and VFNs, these findings are consistent with those of our own study, which is the largest to report LPR?…”

Section: Discussionmentioning

confidence: 99%

“…In this respect, despite the remark that 24-h double probe pH monitoring is considered the gold standard for the diagnosis of LPR, the technique and the interpretation of pharyngeal probe pH monitoring recordings are still somewhat controversial [6,7]. Few previous studies have reported on the prevalence of LPR and GERD in patients with true vocal fold lesions (TVFLs) such as nodules (VFN), polyps (VFP) and Reinke's edema (RE), in particular [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Double probe pH-monitoring findings in patients with benign lesions of the true vocal folds: comparison with typical GERD and the effect of smoking

Beltsis¹,

Katsinelos²,

Kountouras

et al. 2011

Eur Arch Otorhinolaryngol

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We conducted a pH-monitoring study to determine the prevalence of pathologic gastroesophageal reflux (GER+) and laryngopharyngeal reflux (LPR+) in patients with resected benign true vocal fold lesions (TVFLs) and positive reflux finding score (RFS). We compared our findings with those of patients with typical GER disease (GERD) symptoms and normal laryngoscopy. In the group of patients with TVFLs, we compared the pH-monitoring findings of smokers with those of non-smokers. Seventy-two [females 32, mean (SD) age 49.3 (13.1) years] patients with resected TVFLs (polyps: 32, nodules: 20, Reinke's edema: 12, granulomas: 4, leukoplakia: 4) and 24 [females 14, mean (SD) age 42.2 (13.4) years] patients with typical GERD symptoms, who served as controls for the hypopharyngeal measurements, underwent 24-h double probe, hypopharyngeal and distal esophageal, ambulatory pH monitoring. Thirty-eight (52.8%) patients with TVFLs had GER+ and 52 (72.2%) had LPR+. More laryngopharyngeal reflux episodes (LPREs) were detected in patients with TVFLs compared to those with GERD (P < 0.001). With respect to the specific TVFLs, 12 (37.5%) patients with polyps had GER+ and 24 (75%) had LPR+, 6 (30%) patients with nodules had GER+ and 12 (60%) had LPR+, 6 (50%) patients with Reinke's edema had GER+ and 8 (66.7%) had LPR+ and all the patients with granuloma or leucoplakia had both GER+ and LPR+. Twenty (55.6%) of the 36 smokers and 32 (88.9%) of the 36 non-smokers with TVFLs had LPR+ (P = 0.003), while GER+ was recorded in 16 (44.4%) smokers and 22 (61.1%) non-smokers (P = 0.238). Smokers had significantly less LPREs (P < 0.001). In conclusion, 24-h double probe pH monitoring may detect GER+ and/or LPR+ in a substantial proportion of patients with resected TVFLs and positive RFS. Our study suggests that LPR+ is more prevalent in patients with TVFLs compared with typical GERD patients and that non-smokers with TVFLs are more likely to have LPR+ than smokers with TVFLs.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Double probe pH-monitoring findings in patients with benign lesions of the true vocal folds: comparison with typical GERD and the effect of smoking

Beltsis¹,

Katsinelos²,

Kountouras

et al. 2011

Eur Arch Otorhinolaryngol

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“…El manejo médico general apunta a eliminar los factores del paciente y ambientales con riesgo de influir en el resultado del paciente, sea con manejo antirreflujo, fundamental para el resultado posoperatorio, como con el cese del tabaco, el cual lleva a una mayor queratinización, displasia y degeneración hialina del pólipo [18][19][20] . Se han descrito terapias médicas específicas para las lesiones benignas de cuerda vocal.…”

Section: Discussionunclassified

Pólipo bilateral de cuerda vocal: Presentación de un caso clínico

2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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“…Jak podaje Chung, LPR moŜe odgrywać rolę jako czynnik etiologiczny w rozwo-ju polipów oraz obrzęku Reinkego [146]. Ze względu na małą grupę rozpoznań nie podejmowano próby analizy statystycznej tego zjawiska.…”

Section: Omówienieunclassified

Zapalne i nowotworowe zmiany błony śluzowej krtani w chorobie refluksowej

Skrzypczak¹

2011

Otolaryngologia Polska

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The Significance of Laryngopharyngeal Reflux in Benign Vocal Mucosal Lesions

Abstract: Laryngopharyngeal reflux might play a role as an etiologic factor in Reinke's edema and vocal polyps.

Cited by 73 publications

References 17 publications

Double probe pH-monitoring findings in patients with benign lesions of the true vocal folds: comparison with typical GERD and the effect of smoking

Double probe pH-monitoring findings in patients with benign lesions of the true vocal folds: comparison with typical GERD and the effect of smoking

Pólipo bilateral de cuerda vocal: Presentación de un caso clínico

Zapalne i nowotworowe zmiany błony śluzowej krtani w chorobie refluksowej

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