The Significance of Key Regulators of Apoptosis in the Development and Prognosis of Prostate Carcinoma. I. Proteins of the BCL-2 Family and Protein P53

Knillová, Jana; Kolář, Zdeněk

doi:10.5507/bp.2003.001

Cited by 8 publications

(10 citation statements)

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“…На той же выборке пациентов c РПЖ и ДГПЖ было проведено определение сывороточной концентрации белка Bcl-2, который подобно Dj-1 играет важную роль в регуляции процессов апоптоза [17]. Белок Bcl-2 весьма активно изучается у больных раком молочной железы, но некоторые авторы рассматривают Bcl-2 и как перспективный потенциальный биомаркер РПЖ [17][18][19].…”

Section: рисунокunclassified

“…Белок Bcl-2 весьма активно изучается у больных раком молочной железы, но некоторые авторы рассматривают Bcl-2 и как перспективный потенциальный биомаркер РПЖ [17][18][19]. В нашей выборке пациентов средние значения содержания Bcl-2 в сыворотке крови больных РПЖ и ДГПЖ составили, соответственно, 2,90±0,57 и 2,68±0,41 нг/мл.…”

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Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

et al. 2011

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2Российская медицинская академия последипломного образования, 123995 Москва, ул. Баррикадная, д. 2/1 3 Учреждение Российской академии медицинских наук Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича РАМН, 119121 Москва, ул. Погодинская, д. 10При протеомном исследовании образцов тканей простаты, полученных от пациентов с раком (РПЖ) и доброкачественной гиперплазией (ДГПЖ) белок Dj-1 обнаружен в виде двух электрофоретических изоформ. В клеточных линиях РС-3, DU-145, LNCaP и BPH-1 белок Dj-1 также идентифицирован, при этом его наименьшее содержание оказалось в клетках BPH-1, моделирующих ДГПЖ. Иммуноферментное изучение содержания белков Dj-1, Bcl-2, IGF-1 и IGFBP-3 в образцах сыворотки крови выявило статистически достоверные различия между группами больных РПЖ и ДГПЖ (р=0,004, критерий Уилкоксона-Манна-Уитни) только для белка Dj-1. Таким образом, белок Dj-1 представляется перспективным биомаркером РПЖ.Ключевые слова: Dj-1, рак предстательной железы, двумерный электрофорез, иммуноферментный анализ.

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Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

et al. 2011

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“…Bcl-2 is a small intracellular nonglycosylated protein that is able to inhibit the apoptotic pathway when overexpressed in cells [42]. By the TUNEL technique, we viewed a significant decrease in dysplastic acini in comparison to control acini and a representative increase of LI p53 .…”

Section: Discussionmentioning

confidence: 99%

Expression of Lysophosphatidic Acid Receptor 1 and Relation with Cell Proliferation, Apoptosis, and Angiogenesis on Preneoplastic Changes Induced by Cadmium Chloride in the Rat Ventral Prostate

et al. 2013

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BackgroundLysophosphatidic acid (LPA) is a phospholipid growth factor involved in cell proliferation, differentiation, migration, inflammation, angiogenesis, wound healing, cancer invasion, and survival. This study was directed to evaluate the immunoexpression of LPA-1, cell proliferation, apoptosis, and angiogenesis markers in preneoplastic lesions induced with cadmium chloride in rat prostate.MethodsThe following parameters were calculated in ventral prostate of normal rats and rats that received Cd in drinking water during 24 months: percentages of cells immunoreactive to LPA-1 (LILPA1), PCNA (LIPCNA), MCM7 (LIMCM7), ubiquitin (LIUBI), apoptotic cells (LIAPO), and p53 (LIp53); volume fraction of Bcl-2 (VFBcl-2); and length of microvessels per unit of volume (LVMV/mm3). Data were analyzed using Student's t-test and Pearson correlation test.ResultsThe LILPA1 in dysplastic lesions and normal epithelium of Cd-treated rats was significantly higher than those in the control group. Markers of proliferation were significantly increased in dysplastic lesions, whereas some apoptotic markers were significantly decreased. No significant differences between groups were found in VFBcl-2. Dysplastic lesions showed a significant increase of LIp53. The length of microvessels per unit of volume was elevated in dysplastic acini. Statistically significant correlations were found only between LILPA1 and LIUBI.ConclusionsOur results suggest that LPA-1 might be implicated in dysplastic lesions induced by cadmium chloride development. More studies are needed to confirm its potential contribution to the disease.

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“…CD44 glycoprotein performs the function of a cellular surface receptor for hyaluronic acid, a glycoaminoglycoside which takes part in cancer cell metastasizing [12]. Three forms of CD44 have been identified: full length (exons [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], standard (exons [1][2][3][4][5][16][17][18][19][20] and CD44v [13].…”

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“…Bcl-2 is a factor responsible for apoptosis inhibition [9], while p53 is a key factor activating apoptosis in cases of unrepairable DNA injury as a result of a broad-spectrum of stressful agents (e.g. hypoxia or oncogene expression) [10].…”

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Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators

Makarewicz¹,

Żyromska²,

Andrusewicz³

2011

Folia Histochem Cytobiol.

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The Significance of Key Regulators of Apoptosis in the Development and Prognosis of Prostate Carcinoma. I. Proteins of the BCL-2 Family and Protein P53

Cited by 8 publications

References 96 publications

Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

Expression of Lysophosphatidic Acid Receptor 1 and Relation with Cell Proliferation, Apoptosis, and Angiogenesis on Preneoplastic Changes Induced by Cadmium Chloride in the Rat Ventral Prostate

Comparative analysis of biological profiles of benign prostate hyperplasia and prostate cancer as potential diagnostic, prognostic and predictive indicators

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