The significance of hepatic steatosis (HS) in chronic hepatitis B and C

Kryczka, Wiesław; Urbaniak, Antoinette; Chrapek, Magdalena; Michaluk, Dorota; Paluch, Katarzyna

doi:10.1016/s0168-8278(02)80424-x

Cited by 1 publication

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“…21 It usually develops in association with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and other liver diseases such as liver steatosis and fibrosis. 22 The spread of HBV and HCV has resulted in approximately 500 million people with persistent virus infections, 23 some of which will lead to liver cancer, causing a strong rise in HCC incidence. At the same time, the eradication of these chronic viral infections has turned out to be highly ineffective.…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of Toll-like Receptor 2 Via HMGB1 Blocking With Kaempferol on Kupffer Cells From Hepatocellular Carcinoma Patients

Yue,

Ma,

Zhang

et al. 2023

Biomed Res Bull

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Background: Kaempferol is a pharmacological kaempferol that can inhibit many inflammatory factors implicated in cancer. Methods: The present study focused on kaempferol function on the immunity signaling pathway. In this study, Kupffer cells were also isolated with new methods. Results: Our results indicated that the levels of interleukin 17 (IL-17), IL-33, and IL-6 in supernatants from cultured Kupffer cells from patients were increased after stimulation with high mobility group box-1 (HMGB1), but the levels of these cytokines decreased after using kaempferol to prevent inflammation. Conclusion: The findings of this study imply that the reduction of the Toll-like receptor 2 (TLR2) pathway and T helper 17 cell polarization may be due to HMGB1 blocking with Kaempferol in hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 99%