The Significance of Hematologic Abnormalities in Patients With Tuberculosis

Glasser, Robert M.

doi:10.1001/archinte.1970.00310040115014

Cited by 101 publications

(25 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient had not received glucocorticoids, but she was leukopenic. Severe hematologic abnormalities, such as leukopenia and pancytopenia, have been reported as complications of disseminated tuberculosis after bone marrow invasion by mycobacteria [6][7][8]. However, the leukopenia seen in our patient was probably a result of the medullar infiltration by metastatic adenocarcinoma.…”

Section: Discussioncontrasting

confidence: 47%

Unusual Cutaneous Manifestations of Miliary Tuberculosis

Giudice

Bernard

Perrin

et al. 2000

Clinical Infectious Diseases

View full text Add to dashboard Cite

Cutaneous manifestations of miliary tuberculosis are extremely rare. We describe a 62-year-old woman with leukopenia who developed infiltrated dermal-hypodermal and ulcerative cutaneous lesions during the course of miliary tuberculosis. Miliary tuberculosis was diagnosed when Mycobacterium tuberculosis bacilli were isolated by cultures of the bronchoalveolar lavage fluid and blood and when acid-fast bacilli were detected on histopathologic examination of hepatic, pulmonary, and cutaneous biopsy specimens. With the increasing incidence of immunocompromised patients, unusual presentations of tuberculosis may be observed more often. Acute miliary tuberculosis of the skin is an exceptional manifestation that is due to acute hematogenous dissemination of M. tuberculosis to the skin. We describe a patient who had unusual cutaneous manifestations of miliary tuberculosis.

show abstract

Section: Discussioncontrasting

confidence: 47%

Unusual Cutaneous Manifestations of Miliary Tuberculosis

Giudice

Bernard

Perrin

et al. 2000

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Numerous hypotheses have been put forward to explain the occurrence of pancytopenia in tuberculosis and both the tubercle bacilli as well as the AKT have been implicated in its pathogenesis [29]. It has also been suggested by Glasser et al that other causes of pancytopenia must be diligently sought for in these patients [30]. Other causes of pancytopenia were excluded on clinical and laboratory evaluation in our cases.…”

Section: Discussionmentioning

confidence: 71%

An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital

Jain

Naniwadekar

2013

BMC Hematol

View full text Add to dashboard Cite

BackgroundPeripheral pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leucopenia and thrombocytopenia resulting from a number of disease processes. Only a few systematic studies have been published on the topic of pancytopenia, although extensive studies have been done for its different etiological factors like aplastic anemia, megaloblastic anemia, leukemia, etc. Thus, this study was carried out to investigate for and to identify the causes of pancytopenia, to find out the frequency of different causes, to determine the incidence of pancytopenia in relation to sex and age and to compare our findings with those of other similar studies from this part of the world.MethodsThis was a prospective study conducted in the Department of Pathology of a teaching institute and a tertiary care hospital in southern Maharashtra, India, over a period of two years. All the patients referred to the central clinical laboratory for routine complete blood count (CBC) and peripheral smear (PS) examination, from both - the outpatient and the inpatient departments, were screened for pancytopenia. Of these, a total number of 250 cases that fulfilled the diagnostic criteria were selected.Detailed hematological investigations followed by bone marrow aspiration wherever indicated and possible were performed according to standard methods to ascertain the causes of pancytopenia.ResultsA definite male preponderance was observed, the male to female ratio being 2.6 : 1. The majority of cases were encountered in 3rd and 4th decades. Hypersplenism (29.2%), Infections (25.6%), Myelosuppressants (16.8%) and Megaloblastosis (13.2%) were the four most common causes in this large series on pancytopenia from a single centre in India.ConclusionDetailed clinical history and meticulous physical examination along with baseline hematological investigations, provides invaluable information in the complete workup of pancytopenic patients, helping in systematic planning of further investigations to diagnose and ascertain the cause, avoiding a battery of unnecessary tests.

show abstract

“…Severe thrombocytopenia and the presentation of TB as ITP is an extremely rare condition. In one study it was reported that in 3507 TB patients, all but one case of thrombocytopenia occurred in the context of pancytopenia and leukemia [6]. The mechanism of TB-related ITP is unclear.…”

Section: Discussionmentioning

confidence: 99%