2014
DOI: 10.1093/humrep/deu095
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The significance of fragile X mental retardation gene 1 CGG repeat sizes in the normal and intermediate range in women with primary ovarian insufficiency

Abstract: The Prospect-EPIC study was funded by 'Europe Against Cancer' Program of the European Commission (SANCO); the Dutch Ministry of Health; the Dutch Cancer Society; ZonMW the Netherlands Organization for Health Research and Development; World Cancer Research Fund (WCRF) and the Dutch Heart Association.

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Cited by 30 publications
(25 citation statements)
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“…Intraclass correlation coefficients (ICC [3,1]) indicated excellent reliability at 0.99 for both alleles. The allele with the lower CGG repeat length was designated allele-1 and the one with the higher repeat length as allele-2, consistent with the terminology used in prior reports (e.g., Gleicher et al, 2009a; Voorhuis et al, 2014). …”
Section: Methodsmentioning
confidence: 89%
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“…Intraclass correlation coefficients (ICC [3,1]) indicated excellent reliability at 0.99 for both alleles. The allele with the lower CGG repeat length was designated allele-1 and the one with the higher repeat length as allele-2, consistent with the terminology used in prior reports (e.g., Gleicher et al, 2009a; Voorhuis et al, 2014). …”
Section: Methodsmentioning
confidence: 89%
“…We employed an analytic technique that focused on the larger allele as the primary predictor while covarying for the size of the smaller allele, which is the method that has been used most widely in the extant literature (Gleicher et al, 2009a,b; Lledo et al, 2012; Voorhuis et al, 2014; Schufreider et al, 2015). This strategy was successful in detecting robust CGG associations in the present study.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…12 Five of these articles reported separate results for females. [9][10][11]16,19 Nine of the 10 studies that included females reported the total allelic distribution, 9,11,[15][16][17][18][19][20][21] and none of those publications reported the FMR1 distribution of the higher allele separate from the lower allele. The recent article by Voorhuis et al 10 did report separate results for the higher and lower alleles among females from the general population, but their population included women with early menopause at ages 40 to 45 and infertility.…”
Section: Existing Population Data In the Range Ofmentioning
confidence: 99%
“…Subsequently, Pastore et al reported that 14.5 % of DOR patients (n=62) exhibited a high normal number of CGG repeats (35-44) [9]. More recently, researchers have been unable to reconfirm the aforementioned findings nor establish a correlation of CGG repeat number (<55) with measures of ovarian reserve [11,12].…”
Section: Introductionmentioning
confidence: 99%