The significance of fetal inflammatory response syndrome in early and later adaptation of premature infants

Pilypienė, Ingrida; Drazdienė, Nijolė; Dumalakienė, Irena; Vezbergienė, Nijolė; Bartkevičienė, Daiva; Šilkūnas, Mindaugas; Bumbulienė, Žana

doi:10.1007/s00404-014-3386-2

Cited by 9 publications

(14 citation statements)

References 34 publications

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“…Recent studies have demonstrated a correlation between the development of severe RDS and umbilical cord blood IL‐6 concentration . Likewise, in the present study, among the FIRS group, umbilical cord blood IL‐6 concentration of premature infants with RDS was found to be higher than that in infants without RDS.…”

Section: Discussionsupporting

confidence: 77%

“…and Hofer et al. , a correlation was found between inflammatory biomarkers and neonatal death . Pilpiene et al .…”

Section: Discussionmentioning

confidence: 87%

“…Pilpiene et al . found that umbilical cord blood IL‐6 concentration > 12.7 pg/mL in premature infants born before 34 weeks of gestation predicts mortality, while Hofer et al . showed that incidence of death increased with umbilical cord blood IL‐6 concentration > 11 pg/mL in premature infants born before 32 weeks of gestation .…”

Section: Discussionmentioning

confidence: 99%

“…Fetal inflammatory response syndrome (FIRS) is an inflammatory response developed after the exposure of the fetal immune system to intrauterine infection or inflammation. 1 FIRS is defined histologically as funisitis; 2 it is defined biochemically as umbilical cord blood interleukin (IL)-6 concentration > 11 pg/mL. 3 Endothelial dysfunction, multiple organ failure, 4 and preterm labor develops in fetuses with FIRS.…”

mentioning

confidence: 99%

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Morbidity in preterm infants with fetal inflammatory response syndrome

Özalkaya

Karatekın

Topçuoğlu

et al. 2016

Pediatrics International

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Section: Discussionsupporting

confidence: 77%

“…and Hofer et al. , a correlation was found between inflammatory biomarkers and neonatal death . Pilpiene et al .…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Morbidity in preterm infants with fetal inflammatory response syndrome

Özalkaya

Karatekın

Topçuoğlu

et al. 2016

Pediatrics International

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“…25 Moreover, it was associated with adverse neonatal outcomes including intraventricuar hemorrhage, early-onset sepsis, bronchopulmonary dysplasia, death, and RDS. 26,27 In our study, 12,450/mm3 is the cutoff point to predict BA (AUC 0.68, 95%CI 0.57-0.80, Sensitivity 46.7%, Specificity 88%). In addition, Gibbs, et al found 15,750/mm 3 as significant mean level correlated with intraamniotic infection.…”

Section: Discussionmentioning

confidence: 48%

Can we predict birth asphyxia of neonates born from PPROM women?

Fattah¹,

Purwosunu

Sungkar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: To develop a simple and accurate method of predicting birth asphyxia of neonates born from preterm premature rupture of membranes (PPROM) women utilizing clinical parameters that are generally available before delivery in the practical setting.Methods: A retrospective cohort was conducted at single tertiary hospital in Jakarta between January and December 2013. Subjects were PPROM women with singleton live pregnancy who had their delivery on 24 to 34 weeks of gestational age (GA). Primary outcome was birth asphyxia defined by 5th minutes APGAR score < 7. The variables studied were leukocyte counts, gestational age at PPROM, clinical chorioamnitis, severe preeclampsia, mode of delivery, and PPROM-admission duration. Prediction model was developed using logistic regression analysis.Results: One hundred and seventy five out of 380 PPROM women registered in our database met the inclusion criteria. The incidence of BA was 14.29% (25/175). The cutoff value for maternal leukocyte counts and gestational age to predict birth asphyxia was respectively 12,450/mm3 (area under the curve 0.68, 95%CI 0.57-0.80) and 32 weeks (area under the curve 0.81, 95%CI 0.70-0.92). A prediction model was developed consisted of GA at PPROM < 32 weeks of GA (OR=9.58, 95%CI 3.32 – 27.62) and maternal leukocyte counts > 12,450/mm3 (OR=3.6, 95%CI 1.11-11.63), (Final AUC=0.82 (95%CI 0.74-0.89). Clinical chorioamnitis, severe preeclampsia, mode of delivery, PPROM-admission duration was not associated with birth asphyxia.Conclusions: A prediction model to predict BA among PPROM women at 24-34 weeks GA was developed consisted of GA at PPROM and maternal leukocyte counts at patient’s admission.

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Effect of washed versus unwashed red blood cells on transfusion‐related immune responses in preterm newborns

et al. 2022

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Objectives Transfusion with washed packed red blood cells (PRBCs) may be associated with reduced transfusion‐related pro‐inflammatory cytokine production. This may be because of alterations in recipient immune responses. Methods This randomised trial evaluated the effect of transfusion with washed compared with unwashed PRBCs on pro‐inflammatory cytokines and endothelial activation in 154 preterm newborns born before 29 weeks’ gestation. Changes in plasma cytokines and measures of endothelial activation in recipient blood were analysed after each of the first three transfusions. Results By the third transfusion, infants receiving unwashed blood had an increase in IL‐17A ( P = 0.04) and TNF ( P = 0.007), whereas infants receiving washed blood had reductions in IL‐17A ( P = 0.013), TNF ( P = 0.048), IL‐6 ( P = 0.001), IL‐8 ( P = 0.037), IL‐12 ( P = 0.001) and IFN‐γ ( P = 0.001). The magnitude of the post‐transfusion increase in cytokines did not change between the first and third transfusions in the unwashed group but decreased in the washed group for IL‐12 ( P = 0.001), IL‐17A ( P = 0.01) and TNF ( P = 0.03), with the difference between the groups reaching significance by the third transfusion ( P < 0.001 for each cytokine). Conclusion The pro‐inflammatory immune response to transfusion in preterm infants can be modified when PRBCs are washed prior to transfusion. Further studies are required to determine whether the use of washed PRBCs for neonatal transfusion translates into reduced morbidity and mortality.

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The significance of fetal inflammatory response syndrome in early and later adaptation of premature infants

Cited by 9 publications

References 34 publications

Morbidity in preterm infants with fetal inflammatory response syndrome

Morbidity in preterm infants with fetal inflammatory response syndrome

Can we predict birth asphyxia of neonates born from PPROM women?

Effect of washed versus unwashed red blood cells on transfusion‐related immune responses in preterm newborns

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