The Significance of Epithelial Differences in Mixed Mesodermal Tumors of the Uterus

Bitterman, Pincas; Chun, Byungkyu; Kurman, Robert J.

doi:10.1097/00000478-199004000-00002

Cited by 154 publications

(71 citation statements)

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“…Neoplasms with mixed epithelial and sarcomatous differentiation are relatively common and have been reported in a variety of organs including the breast, lung, uterus, bladder, skin, head and neck, pancreas, and prostate (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In some of these neoplasms, a transition between the epithelial and stromal components can be readily recognized, whereas in others, the carcinomatous and sarcomatous portions of the tumor are distinct.…”

mentioning

confidence: 99%

Pancreatic Mucinous Cystic Neoplasms with Sarcomatous Stroma: Molecular Evidence for Monoclonal Origin with Subsequent Divergence of the Epithelial and Sarcomatous Components

et al. 2000

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Neoplasms with mixed carcinomatous and sarcomatous growth patterns occur in many organs and tissues. The pathogenesis of these cancers is thought to be either the result of two independent neoplastic processes merging to form a single tumor, or a neoplasm of monoclonal origin that develops phenotypic diversity. To address this issue, we characterized molecular alterations in separately microdissected epithelial and sarcomatous areas in three cases of pancreatic mucinous cystic neoplasms with sarcomatous stroma. Using microsatellite markers for six chromosomal loci commonly deleted in infiltrating ductal adenocarcinomas of the pancreas, we found genetic alterations to be virtually identical between the sarcomatous and epithelial components of two of the three neoplasms. In the third neoplasm, we found allelic losses and retentions to be identical at five of the six chromosomal loci, but at a single locus, we noted allelic loss in the neoplastic epithelial component but not the sarcomatous component. The same neoplasms were also analyzed for activating point mutations in codon 12 of the K-ras gene by using mutant-enriched polymerase chain reaction and allele-specific oligonucleotide hybridization. A K-ras mutation was identified in the epithelial component of one of the three neoplasms (the same tumor with an additional allelic loss in the neoplastic epithelial cells), but the sarcomatous component of this tumor was wild-type at codon 12 of K-ras, as were both components of the other two neoplasms.Overall, these results suggest a monoclonal origin with subsequent divergence of the neoplastic epithelial and sarcomatous portions of these neoplasms.

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mentioning

confidence: 99%

Pancreatic Mucinous Cystic Neoplasms with Sarcomatous Stroma: Molecular Evidence for Monoclonal Origin with Subsequent Divergence of the Epithelial and Sarcomatous Components

et al. 2000

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“…The usual tumor is composed of obvious carcinoma, which may be mucinous, squamous, endometrioid, high-grade papillary, clear cell, undifferentiated, or mixtures of these types, and a second component of spindle cells, which, when heterologous differentiation or leiomyosarcoma is present, is easy to recognize as sarcomatous (37)(38)(39)(40). Difficulties arise primarily in trying to decide whether an undifferentiated component is carcinoma or sarcoma.…”

Section: Carcinosarcoma (Malignant Mixed Mü Llerian Tumor)mentioning

confidence: 99%

“…Unfortunately, keratin stains are not helpful in this circumstance because sarcomatous elements in carcinosarcoma may be composed of keratin-positive cells. This suggests that uterine carcinosarcomas may in fact be metaplastic carcinomas (37,40).…”

Section: Carcinosarcoma (Malignant Mixed Mü Llerian Tumor)mentioning

confidence: 99%

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Smooth Muscle, Endometrial Stromal, and Mixed Müllerian Tumors of the Uterus

2000

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“…Yeni çalışmalar ayrıca, bu tümörlerin epitelyal komponentin özelliklerine göre davrandığını da ortaya koymuştur. Epitelyal komponent lenfatik ve vasküler boşluklara yayılabilir ve metastaz yapabilirken, iğsi hücreli komponent oldukça sınırlı metastaz potansiyeline sahiptir (4,5). Klinik prezantasyonları endometrial adenokarsinomlara çok benzemektedir.…”

Section: Introductionunclassified

Uteri̇n Karsi̇nosarkomlar: 18 Olguda Hi̇stopatoloji̇k Gözden Geçi̇rme

et al. 2015

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Objective: Uterine carcinosarcomas are relatively rare tumors with poor prognosis. These tumors were considered as a subset of uterine sarcomas; however currently they are classified within the carcinoma group. Recent studies have revealed that these tumors behave according to the characteristics of the epithelial component. The aim of the study was to discuss the histopathological characteristics of these quite aggressive tumors, which were diagnosed in our clinic, in the light of the literature. Materials and Methods:We performed a retrospective analysis of 18 patients with uterine sarcoma, who were operated at our oncology department between 2004 and 2014. Cases with a pathology result of either carcinosarcoma or malignant mixed Müllerian tumor were included in the study pathologically. Tumor size, presence of myometrial invasion and pelvic lymph node metastases were reviewed. Demographic data were recorded. Staging was performed according to FIGO (1988) protocol.Results: 18 patients were diagnosed with carcinosarcoma. 95% of the patients were in postmenopausal period. The mean age was 64.6 (range 47-85). 13 patients underwent comprehensive surgical staging (total hysterectomy + bilateral salpingo-oophorectomy + pelvic para-aortic lymphadenectomy + omentectomy + appendectomy). 5 patients with advanced stage disease underwent suboptimal debulking. 7 patients were stage I and 11 patients were stage II-IV. Myometriyal invasion was present in 17 patients and for 9 of these patients the invasion was observed in more than ½ of the myometrium. Lymphovascular invasion was observed in 11 patients. Conclusion: Uterine carcinosarcomas are extremely aggressive neoplasms. Although they used to be categorized under the group of sarcoma, recent studies have shown that uterine carcinosarcomas are high-grade endometrial carcinomas, which include sarcomatous metaplasia. First-line treatment for uterine carcinosarcomas is surgery. Adjuvant chemotherapy and radiation therapy combinations are used as complementary therapies.

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The Significance of Epithelial Differences in Mixed Mesodermal Tumors of the Uterus

Cited by 154 publications

References 0 publications

Pancreatic Mucinous Cystic Neoplasms with Sarcomatous Stroma: Molecular Evidence for Monoclonal Origin with Subsequent Divergence of the Epithelial and Sarcomatous Components

Pancreatic Mucinous Cystic Neoplasms with Sarcomatous Stroma: Molecular Evidence for Monoclonal Origin with Subsequent Divergence of the Epithelial and Sarcomatous Components

Smooth Muscle, Endometrial Stromal, and Mixed Müllerian Tumors of the Uterus

Uteri̇n Karsi̇nosarkomlar: 18 Olguda Hi̇stopatoloji̇k Gözden Geçi̇rme

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