The significance of cytogenetic findings of erythroid colonies derived from a Ph+ ALL patient: Fundamental differences between Ph+ ALL and blastic phase CML

Abe, Rokuo; Ishibashi, Toshiyuki; Kimura, Hideo; Uchida, Tatsuo; Kariyone, S

doi:10.1016/0165-4608(85)90039-1

Cited by 13 publications

(5 citation statements)

References 13 publications

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“…We can confirm the results of Abe et al (1985) and found no evidence for the involvement of the erythropoiesis in the malignant transformation. Only a few megakaryocytes were detectable with CD41 in three patients and may be involved in a low percentage in one of them.…”

Section: Discussionsupporting

confidence: 80%

New insights into the biology of Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques at the single cell level

Haferlach

Winkemann²,

Ramm‐Petersen³

et al. 1997

Br J Haematol

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It is sometimes difficult to discriminate chronic myeloid leukaemia (CML) in lymphatic blast crisis from Ph‐chromosome positive acute lymphoblastic leukaemia (ALL). Previous studies have suggested that ALL is restricted to the lymphatic lineage only, whereas CML involves all cell lineages. In four cases of Ph‐positive ALL we combined the standard May‐Grünwald‐Giemsa staining with FISH at the single cell level and were able to demonstrate that 98% of lymphatic blasts carried the Philadelphia chromosome. Erythropoiesis was not involved when this technique was applied. Using immunological identification of single cells (FICTION), we detected the t(9;22) in 100% of CD19‐positive B lymphoblasts in all four cases, in some CD3‐positive T cells in two patients, and in 98% of CD34‐positive precursor cells. However, in two out of four patients the myeloid cell compartment was involved in the malignant transformation, unequivocally demonstrated not only by the combination of MGG and FISH but also by FICTION using the antibodies CD13 and CD33. The observation that both patients with myeloid cell lineage involvement had a myeloid co‐expression on their blasts and a better survival supports the concept of a separate, biologically determined subgroup in Ph‐positive ALL, leading to further investigations, and individually tailored treatment strategies.

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Section: Discussionsupporting

confidence: 80%

New insights into the biology of Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques at the single cell level

Haferlach

Winkemann²,

Ramm‐Petersen³

et al. 1997

Br J Haematol

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“…2,3 The underlying hypothesis is that a lymphoid-determined progenitor cell undergoes neoplastic transformation. In contrast, chronic myeloid leukemia (CML), which is considered to originate from a pluripotent stem cell, 4,5 shows multilineage involvement.…”

Section: Introductionmentioning

confidence: 99%

Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia

et al. 1998

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“…Evidence of a common stem cell origin in ALL and CML based on the observation of a chromo some polymorphism has been reported [13]. On the other hand, Abe et al [1] have found a fundamental difference in colonies from erythroid burst-forming units (BFU-E) derived from bone marrow cells of Phpositive ALL and BP of CML. In fact, metaphases from erythroid colonies of Ph-positive ALL have Phnegative karyotypes, unlike BP of CML ones.…”

Section: Discussionmentioning

confidence: 99%

Additional Chromosomal Abnormalities to Ph during the Clinical Course in Patients with Acute Lymphoblastic Leukemia

et al. 1986

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Cytogenetic findings obtained during the clinical course in two patients (one child and one adult) with Ph-positive acute lymphoblastic leukemia (ALL) are reported. Chromosomal abnormalities in addition to Ph chromosome were detected in both patients. At the beginning of the disease, such abnormalities consisted of the trisomy of chromosome 1 and monosomy of chromosomes 8 and 9, with a sub-line 45, X Y, Ph, -8 in the child; in the adult patient a hyperdiploid clone with 57–59 chromosomes and Ph duplication was present. At relapse, the same karyotypic anomalies reappeared in the child, whereas in the adult a high frequency of chromosomal rearrangements, such as ring and dicentric chromosomes, was observed after cranial irradiation. The occurrence of chromosomal abnormalities additional to Ph during the clinical course in ALL patients is discussed, taking into account data from the literature concerning the lymphoid blastic crisis in chronic myeloid leukemia patients.

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The significance of cytogenetic findings of erythroid colonies derived from a Ph+ ALL patient: Fundamental differences between Ph+ ALL and blastic phase CML

Cited by 13 publications

References 13 publications

New insights into the biology of Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques at the single cell level

New insights into the biology of Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques at the single cell level

Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia

Additional Chromosomal Abnormalities to Ph during the Clinical Course in Patients with Acute Lymphoblastic Leukemia

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