The significance of circulating endothelin-1 as a predictor of coronary artery disease status and clinical outcomes following coronary artery catheterization

Mayyas, Fadia; Al-Jarrah, M; Ibrahim, Khalid S.; Mfady, Doa'a; Wagoner, David R. Van

doi:10.1016/j.carpath.2014.08.004

Cited by 27 publications

(25 citation statements)

References 27 publications

(37 reference statements)

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“…An appropriate amount of NO could protect cardiomyocytes, reduce damage, inhibit intimal hyperplasia and ameliorate the heart function following IR injury. As an important regulator of cardiovascular function, ET plays a significant role in maintaining vascular tension and cardiovascular system steady state (25). Endothelial cells stimulate the synthesis and release of ET-1.…”

Section: Discussionmentioning

confidence: 99%

Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus

Wang

et al. 2016

Biomedical Reports

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Abstract. The current study aimed to examine the effects of propofol on myocardial ischemia-reperfusion injury (MIRI) in rats with type-2 diabetes mellitus (T2DM) and to assess the role of inflammatory mediators. Fifty healthy male adult Sprague-Dawley rats were randomly divided into the sham, ischemia-reperfusion (IR), IR plus low, middle and high-dose (6, 12 and 24 mg/kg/h, intravenous) propofol groups. The rats of all the groups were fed a high-sugar and high-fat diet for 8 weeks and streptozotocin (30 mg/kg, intraperitoneally) was used to establish the T2DM model. Apart from the sham group rats, MIRI was induced by ligating the left anterior descending coronary artery for 30 min, followed by reperfusion for 2 h. Heart rate (HR), left ventricular systolic pressure (LVSP), and the rate of left ventricular pressure increase in early systole (± dp/dt max ) were recorded. Levels of cardiac troponin T (cTnT), nitric oxide (NO), endothelin-1 (ET-1), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α were also measured. Myocardial lesions were observed under light microscopy and scanning electron microscopy. Compared with levels prior to arterial occlusion, HR, LVSP, and ± dp/dt max were significantly reduced (P<0.05) following occlusion for 30 min and reper fusion for 2 h. The administration of propofol ameliorated the cardiac function of rats as reflected by the increase in HR, LVSP and ± dp/dt max . In addition, the administration of propofol increased the serum NO concentration, and reduced ET-1 and cTnT levels, as well as levels of inflammatory mediators including IL-1β, IL-6 and TNF-α. Thus, propofol exerts protective effects against MIRI in T2DM rats by increasing NO and reducing ET-1 and the inflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus

Wang

et al. 2016

Biomedical Reports

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“…In addition, Our study showed a statistically significant increase in the ET-1 values among patients compared to control subjects, which reflects its role not only in prolonged vasoconstriction but also its atherogenic impact, its pro-oxidant effect and its pro-aggregating role [ 4 , 15 ].…”

Section: Discussionmentioning

confidence: 92%

Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

Chalghoum

Noichri

Karkouch³

et al. 2015

biol res

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BackgroundAcute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore the variation of two coronary risk parameters not mentioned by Framingham cohorts, hyperhomocysteinemia and endothelin-1 (ET-1) in Tunisian coronary and the study of the variation of these parameters based on various cardiac risk factors and metabolic relationship between them.To 157 coronary and 142 healthy subjects, the concentration of homocysteine was quantified by fluorescence polarization immunoassay; the concentration of ET-1 was measured by an analytical technique, the High Performance Liquid Chromatography (HPLC) coupled with mass spectrometry.ResultsOur study showed that homocysteine and ET-1 were significantly higher in patients compared to healthy subjects (24.40 ± 12.5 μmol/L vs 7.44 ± 2.5 μmol/L p <0.00001) for homocysteine and (15.2 ± 5.3 nmol/L vs 7.1 ± 2.7 nmol/L, p <0.00001) for ET-1. On the other hand, homocysteine varies according to tobacco and diabetes while ET-1 depends on the sex, hypertension, smoking, obesity and dyslipidemia and a statistically negative correlation was shown between homocysteine and ET-1 in coronary patients (r = −0.66 p <0.00001).ConclusionThe study of the variation of these two parameters in coronary patients and metabolic exploration of the relationship between homocysteine and ET-1 according to various risk factors and the interactions between themselves facilitates the decision of therapeutic treatment.

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“…Mayyas et al 28 found that ET-1 was significantly higher in patients with STEMI than in those with NSTEMI one week after an acute event. Reperfusion therapy in AMI increases oxidative stress which leads to decrease of NO and its protective effects during ischemia 29 .…”

Section: Discussionmentioning

confidence: 99%

Endothelin-1 and nitric oxide in 3-year prognosis after acute myocardial infarction

Stanojević¹,

Apostolović²,

Šalinger-Martinović³

et al. 2017

VOJNOSANIT PREGL

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Background/Aim. Acute myocardial infarction (AMI) is an important cause of mortality/morbidity worldwide. Biomarkers improve diagnostic and prognostic accuracy in AMI. The aim of this study was to investigate an increase of markers of endothelial dysfunction in AMI, measured on the 3rd day after the initial event and to investigate their association with short-and long-term (3-year) prognosis (outcome). Methods. The prospective study included 108 patients with AMI in the experimental group and 50 apparently healthy subjects in the control group. Endothelin-1 (ET-1) and nitric oxide degradation products (NOx) were determined. Results. The average age of the participants in the experimental group was 62 ± 10 years and 59 ± 9 years in the control group; 74.1% of the patients in experimental group were males and 68.8% in the control group. In 74.1% of the patients, ST-elevation myocardial infarction (STEMI) was diagnosed, and 25.9% of the patients presented with non-ST-elevation myocardial infarction (NSTEMI). Thirteen (5.6%) patients died during 3 years and they had significantly higher ET-1 levels compared to survivors [4.02 (2.72-5.93) vs 3.06 (2.23-3.58) pg/mL; p = 0.015]. Endothelin-1 in 46 (42.6%) patients with composite endpoint (3year mortality and rehospitalization) was significantly increased compared to other patients [3.14 (2.54-4.41) vs 3.05 (2.18-3.56) pg/mL; p = 0.035]. Intrahospital complications were found in 41 (48%) patients. Participants with echocardiographically detected complications (ventricular dyskinesia, left ventricular thrombus and papillary muscle rupture) had higher ET-1 levels compared to other patients [4.02 (2.78-5.57) vs 3.06 (2.29-3.66) pg/mL; p = 0.012]. Endothelin-1 concentration above the 75th percentile (> 3.77 pg/mL) was associated with the increased risk for composite endpoint [Log Rank (χ 2 = 13.44; p < 0.001)]. Patients who were rehospitalized had significantly lower NOx concentration [125.5 (111.4-143.6) vs 139.3 (116.79-165.2) µmol/L; p = 0.04]. Endothelin-1 positively correlated with high sensitivity troponin I (hsTnI), brain natriuretic peptide (BNP) and a number of leukocytes. Conclusion. Endothelin-1 and NOx were increased on the 3rd day after AMI, and they were predictors of worse short-and long-term (3year) prognosis (outcome). Endothelin-1 positively correlated with conventional prognostic markers in AMI.

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The significance of circulating endothelin-1 as a predictor of coronary artery disease status and clinical outcomes following coronary artery catheterization

Cited by 27 publications

References 27 publications

Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus

Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus

Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

Endothelin-1 and nitric oxide in 3-year prognosis after acute myocardial infarction

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