The Significance of Biliary Pressure

Williams, Roger D.; Fish, Jay C.; Williams, Drew D.

doi:10.1001/archsurg.1967.01330150050008

Cited by 23 publications

(3 citation statements)

References 8 publications

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“…Reports on the level of intrabiliary pressure in dogs have varied in most cases within the range of 0-130 mmHeO (POTTER & MANN 1926, PARRY et al 1955, WILLIAMS 1967, HANSSON 1968. MENGUY et al (1958) recorded an intrabiliary pressure of 111 mmHeO in cholecystectomized dogs, against 71 mmHeO in normall experimental animals.…”

Section: Response Of the Choledochoduodenal Junction To Drugsmentioning

confidence: 99%

Studies on Drugs Affecting the Choledochoduodenal Junction in Rabbits

Luoma

1971

Acta Pharmacologica et Toxicologica

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Section: Response Of the Choledochoduodenal Junction To Drugsmentioning

confidence: 99%

Studies on Drugs Affecting the Choledochoduodenal Junction in Rabbits

Luoma

1971

Acta Pharmacologica et Toxicologica

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“…According to clinical data, a fully obstructed BD totally encumbers bile and gives considerable rise to the pressure inside the duct (Huang et al 1969;Lygidakis and Brummelkamp 1985;Williams et al 1967). In contrast, a partially obstructed BD shows insignificant intraductal pressure rise and increase in diameter, while bile can flow through the obstruction down the sphincter of Oddi (Dodds et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of Bile Secretion and Pressure Rise in Obstructed Human Common Bile Duct

2021

JAFM

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A fully obstructed Common Bile Duct (CBD) could lead to severe implications such as jaundice, cholangitis, and pancreatitis. A 2-D CFD model with the employment of Fluid-structure Interaction (FSI) formulations is established to investigate the interactions of bile with its surroundings. Ascertaining bile secretion against a total CBD obstruction is a major interest of this study. Therefore, a function is assigned to bile secretion pattern such that the resulting intraluminal pressure complies with clinical data. To cover the variation in the parameters representing the mechanical properties of the biliary system as well as bile secretion, specific piecewise ranges are given for each of them and consequently, numerous cases are simulated. Models which after simulation lead to pressure rises in the interval of 700 Pa to 1300 Pa are picked. This interval could roughly include the actual pressure rise of a vast majority of patients. It is determined that among numerous cases, higher distention does not necessarily correlate with higher pressure increase. Furthermore, the effect of alteration in each parameter in pressure rise is determined. This model is the first numerical step towards understanding the pathogenesis of complications resulting from a fully obstructed CBD and deformation of the CBD in general.

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“…Experiments have revealed that acute obstructive cholangitis appears only when the hydrostatic pressure in the common bile duct increases to critically high levels that enable bacteria to invade from the obstructed bile duct into the systemic circulation 7. The pressure in the normal common bile duct of the dog is 70 mmH 2 O 8. Injection of E. coli into the common bile duct did not exhibit any toxic effects observed in septicemia.…”

Section: Introductionmentioning

confidence: 99%

Pathophysiology of acute obstructive cholangitis

Kawada

Takemura

Minamiyama

et al. 1996

J Hep Bil Pancr Surg

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Because acute obstructive cholangitis is life-threatening, understanding of the pathophysiology of this disease is required to establish a medical treatment. Experimental results indicate that obstruction of the bile duct itself does not induce acute cholangitis, but infection of gut-derived bacteria such as Escherichia coli into the bile triggers fatal septicemia, which leads to liver injury and renal failure. In obstructive cholangitis, functional changes in sinusoidal lining cells are often seen. Mediators produced by Kupffer cells, endothelial cells, and stellate cells may modulate inflammatory reactions especially in the periportal area of bile duct ligated animals. In addition, proliferation of bile duct epithelial cells is induced by bile duct ligation. Recently, nitric oxide has been recognized as an important mediator of multiple organ failure. Actually, when bile duct ligated animals are treated with endotoxin, metabolites of nitric oxide in blood and plasma increase, indicating that nitric oxide may take part in the pathophysiology of acute obstructive cholangitis.

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The Significance of Biliary Pressure

Cited by 23 publications

References 8 publications

Studies on Drugs Affecting the Choledochoduodenal Junction in Rabbits

Studies on Drugs Affecting the Choledochoduodenal Junction in Rabbits

Numerical Investigation of Bile Secretion and Pressure Rise in Obstructed Human Common Bile Duct

Pathophysiology of acute obstructive cholangitis

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