The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa

Renal Involvement in Children with Vasculitis

“…There were an equal number of girls and boys. These features are similar to those reported in smaller series of children: The average ages of patients were 9.3 and 7.5 years in two series both including infants [25,26]. In the aforementioned multinational study, renal involvement was present in a significant proportion of the patients.…”

“…In another series of 6 pediatric patients from India, 3 presented with pulmonary-renal syndrome [41]. We reported a series of 25 patients with PAN, 10 of whom were classified as small vessel necrotizing arteritis (microscopic PAN) [25]. Six developed renal failure, and three of them had pulmonary-renal syndrome.…”

Microscopic polyangitis presenting with sub-acute reversible optic neuropathy

“…3 Therefore, they are positive in Wegners granulamatosis (WG) and MPA and may also be positive in Kawasaki disease, polyarteritis nodosa, systemic lupus (SLE), Crohn's disease, and ulcerative colitis. Two binding specificities are recognized in antinuclear cytoplasmic antibodies: the immunofluorescent cytoplasmic granules with interlobular accentuation (C-ANCA) and the perinuclear pattern (P-ANCA).…”

“…2 Diffuse choroidal haemangioma can lead to visual loss due to refractive errors, foveal distortion, and exudative retinal detachment. 1 Tumour regression and resolution of subretinal fluid can be induced with low-dose radiotherapy 3 or proton beam radiotherapy. 4 Photodynamic therapy (PDT) is currently being advocated for circumscribed choroidal haemangioma with good short-term results.…”

Successful treatment of pediatric systemic polyarteritis nodosa with cholestatic hepatitis

“…Clinical features of PAN in children are different than in adults according to recent reports [5][6][7]. It is suggested that pediatric PAN is a different entity, and it can be classified into four subtypes: cutaneous PAN, systemic PAN, microscopic polyarteritis, and hepatitis-B-associated classic PAN [8].…”